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POR cytochrome p450 oxidoreductase [ Homo sapiens (human) ]

Gene ID: 5447, updated on 16-Sep-2019

Summary

Official Symbol
PORprovided by HGNC
Official Full Name
cytochrome p450 oxidoreductaseprovided by HGNC
Primary source
HGNC:HGNC:9208
See related
Ensembl:ENSG00000127948 MIM:124015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPR; CYPOR; P450R
Summary
This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 99.7), adrenal (RPKM 78.6) and 25 other tissues See more
Orthologs

Genomic context

See POR in Genome Data Viewer
Location:
7q11.23
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (75915155..75986855)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75544420..75616173)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene THO complex 4 pseudogene Neighboring gene rhomboid domain containing 2 Neighboring gene microRNA 4651 Neighboring gene ribosomal protein L7 like 1 pseudogene 3 Neighboring gene small nucleolar RNA, H/ACA box 14A Neighboring gene transmembrane protein 120A Neighboring gene serine/threonine/tyrosine interacting like 1 Neighboring gene malate dehydrogenase 2 Neighboring gene RNA, U6 small nuclear 863, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with POR; predicted interaction to be within the endoplasmic reticulum PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Cytochrome P450 - arranged by substrate type, organism-specific biosystem (from REACTOME)
    Cytochrome P450 - arranged by substrate type, organism-specific biosystemThe P450 isozyme system is the major phase 1 biotransforming system in man, accounting for more than 90% of drug biotransformations. This system has huge catalytic versatility and a broad substrate s...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Oxidation by Cytochrome P450, organism-specific biosystem (from WikiPathways)
    Oxidation by Cytochrome P450, organism-specific biosystemOxidation of a substrate by Cytochrome P450. Adapted from Niesink et al., Chapter 3, p. 47-48.
  • Phase 1 - Functionalization of compounds, organism-specific biosystem (from REACTOME)
    Phase 1 - Functionalization of compounds, organism-specific biosystemPhase 1 of metabolism is concerned with functionalization, that is the introduction or exposure of functional groups on the chemical structure of a compound. This provides a 'handle' for phase 2 conj...
  • bile acid biosynthesis, neutral pathway, organism-specific biosystem (from BIOCYC)
    bile acid biosynthesis, neutral pathway, organism-specific biosystemGeneral Background The biosynthesis of bile acids is a major route of : CHOLESTEROL catabolism. It converts the hydrophobic, insoluble : CHOLESTEROL molecule into soluble bile acids. Accumulation ...
  • bile acid biosynthesis, neutral pathway, conserved biosystem (from BIOCYC)
    bile acid biosynthesis, neutral pathway, conserved biosystemGeneral Background The biosynthesis of bile acids is a major route of |FRAME: CHOLESTEROL| catabolism. It converts the hydrophobic, insoluble |FRAME: CHOLESTEROL| molecule into soluble bile acids. ...
  • melatonin degradation I, organism-specific biosystem (from BIOCYC)
    melatonin degradation I, organism-specific biosystemGeneral Background The indoleamine : N-ACETYL-5-METHOXY-TRYPTAMINE is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. : N-ACETYL-...
  • melatonin degradation I, conserved biosystem (from BIOCYC)
    melatonin degradation I, conserved biosystemGeneral Background The indoleamine |FRAME: N-ACETYL-5-METHOXY-TRYPTAMINE| is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. |FRA...
  • superpathway of melatonin degradation, conserved biosystem (from BIOCYC)
    superpathway of melatonin degradation, conserved biosystemThe indoleamine |FRAME: N-ACETYL-5-METHOXY-TRYPTAMINE| is a vertebrate hormone secreted by the pineal gland. It is involved in regulation of circadian and seasonal rhythms. |FRAME: N-ACETYL-5-METHO...
  • superpathway of melatonin degradation, organism-specific biosystem (from BIOCYC)
    superpathway of melatonin degradation, organism-specific biosystem
    superpathway of melatonin degradation
  • superpathway of tryptophan utilization, organism-specific biosystem (from BIOCYC)
    superpathway of tryptophan utilization, organism-specific biosystem
    superpathway of tryptophan utilization
  • vitamin D3 biosynthesis, organism-specific biosystem (from BIOCYC)
    vitamin D3 biosynthesis, organism-specific biosystemGeneral Background Vitamin D occurs in two forms, : VITAMIN_D3 (cholecalciferol) produced in animal skin after exposure to : UV-Light and : Heat, and : VITAMIN_D2 (ergocalciferol) produced in plants...
  • vitamin D3 biosynthesis, conserved biosystem (from BIOCYC)
    vitamin D3 biosynthesis, conserved biosystemGeneral Background Vitamin D refers to a group of fat-soluble secosteroids responsible for enhancing intestinal absorption of calcium, iron, magnesium, phosphate and zinc. In humans, the most impor...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ26468, DKFZp686G04235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADP binding IEA
Inferred from Electronic Annotation
more info
 
NADPH-hemoprotein reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NADPH-hemoprotein reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
NADPH-hemoprotein reductase activity TAS
Traceable Author Statement
more info
PubMed 
cytochrome-b5 reductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
 
electron transfer activity IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IEA
Inferred from Electronic Annotation
more info
 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
iron-cytochrome-c reductase activity IEA
Inferred from Electronic Annotation
more info
 
nitric oxide dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
carnitine metabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular organofluorine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to follicle-stimulating hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to peptide hormone stimulus IEA
Inferred from Electronic Annotation
more info
 
demethylation IEA
Inferred from Electronic Annotation
more info
 
electron transport chain IEA
Inferred from Electronic Annotation
more info
 
fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
 
flavonoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
internal peptidyl-lysine acetylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipase activity IEA
Inferred from Electronic Annotation
more info
 
nitrate catabolic process IEA
Inferred from Electronic Annotation
more info
 
nitric oxide catabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of chondrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of monooxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of steroid hormone biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of growth plate cartilage chondrocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to nutrient IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADPH--cytochrome P450 reductase
Names
NADPH--hemoprotein reductase
NADPH-dependent cytochrome P450 reductase
P450 (cytochrome) oxidoreductase
NP_000932.3
NP_001354491.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008930.1 RefSeqGene

    Range
    5001..76754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000941.3NP_000932.3  NADPH--cytochrome P450 reductase

    See identical proteins and their annotated locations for NP_000932.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AF258341, AK129978, BC034277, BG104767, BP244929
    Consensus CDS
    CCDS5579.1
    UniProtKB/Swiss-Prot
    P16435
    Related
    ENSP00000419970.1, ENST00000461988.6
    Conserved Domains (3) summary
    cd06204
    Location:280679
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:55679
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:85222
    Flavodoxin_1; Flavodoxin
  2. NM_001367562.1NP_001354491.1  NADPH--cytochrome P450 reductase

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC005067, AC006330

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    75915155..75986855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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