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Por P450 (cytochrome) oxidoreductase [ Mus musculus (house mouse) ]

Gene ID: 18984, updated on 12-Oct-2017
Official Symbol
Porprovided by MGI
Official Full Name
P450 (cytochrome) oxidoreductaseprovided by MGI
Primary source
MGI:MGI:97744
See related
Ensembl:ENSMUSG00000005514 Vega:OTTMUSG00000029621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPR; CYPOR; P450R; 4933424M13Rik
Orthologs
Location:
5 G2; 5 75.34 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (135670040..135735326)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (136165084..136211195)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) ligand 24 Neighboring gene rhomboid domain containing 2 Neighboring gene predicted gene 15607 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene predicted gene, 40345 Neighboring gene transmembrane protein 120A Neighboring gene microRNA 7034 Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene uncharacterized LOC105244798

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
FMN binding ISO
Inferred from Sequence Orthology
more info
 
NADP binding ISO
Inferred from Sequence Orthology
more info
 
NADPH-hemoprotein reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
NADPH-hemoprotein reductase activity ISO
Inferred from Sequence Orthology
more info
 
cytochrome-b5 reductase activity, acting on NAD(P)H ISO
Inferred from Sequence Orthology
more info
 
electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
iron-cytochrome-c reductase activity ISO
Inferred from Sequence Orthology
more info
 
nitric oxide dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
cellular organofluorine metabolic process ISO
Inferred from Sequence Orthology
more info
 
demethylation ISO
Inferred from Sequence Orthology
more info
 
fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
internal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of lipase activity ISO
Inferred from Sequence Orthology
more info
 
nitrate catabolic process ISO
Inferred from Sequence Orthology
more info
 
nitric oxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of growth plate cartilage chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
NADPH--cytochrome P450 reductase
Names
NADH cytochrome P450 oxydoreductase
NP_032924.1
XP_006504461.1
XP_006504462.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008898.2NP_032924.1  NADPH--cytochrome P450 reductase

    See identical proteins and their annotated locations for NP_032924.1

    Status: VALIDATED

    Source sequence(s)
    AC083948
    Consensus CDS
    CCDS39318.1
    UniProtKB/Swiss-Prot
    P37040
    Related
    ENSMUSP00000005651.6, OTTMUSP00000038028, ENSMUST00000005651.12, OTTMUST00000073476
    Conserved Domains (3) summary
    cd06204
    Location:277677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:52677
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:82219
    Flavodoxin_1; Flavodoxin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    135670040..135735326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504399.1XP_006504462.1  NADPH--cytochrome P450 reductase isoform X1

    See identical proteins and their annotated locations for XP_006504462.1

    UniProtKB/Swiss-Prot
    P37040
    Conserved Domains (3) summary
    cd06204
    Location:277677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:52677
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:82219
    Flavodoxin_1; Flavodoxin
  2. XM_006504398.1XP_006504461.1  NADPH--cytochrome P450 reductase isoform X1

    See identical proteins and their annotated locations for XP_006504461.1

    UniProtKB/Swiss-Prot
    P37040
    Conserved Domains (3) summary
    cd06204
    Location:277677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    COG0369
    Location:52677
    CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]
    pfam00258
    Location:82219
    Flavodoxin_1; Flavodoxin
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