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Por cytochrome p450 oxidoreductase [ Mus musculus (house mouse) ]

Gene ID: 18984, updated on 5-Feb-2023

Summary

Official Symbol
Porprovided by MGI
Official Full Name
cytochrome p450 oxidoreductaseprovided by MGI
Primary source
MGI:MGI:97744
See related
Ensembl:ENSMUSG00000005514 AllianceGenome:MGI:97744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CPR; CYPOR; P450R; 4933424M13Rik
Summary
Enables oxidoreductase activity. Predicted to be involved in several processes, including cellular organofluorine metabolic process; negative regulation of hydrolase activity; and positive regulation of steroid biosynthetic process. Predicted to be located in membrane and mitochondrion. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; limb; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and cytochrome P450 oxidoreductase deficiency. Orthologous to human POR (cytochrome p450 oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 159.7), lung adult (RPKM 143.3) and 27 other tissues See more
Orthologs
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Genomic context

See Por in Genome Data Viewer
Location:
5 G2; 5 75.34 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135698894..135764180)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135670040..135735326)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-C motif) ligand 24 Neighboring gene rhomboid domain containing 2 Neighboring gene predicted gene 15607 Neighboring gene predicted gene, 40345 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene transmembrane protein 120A Neighboring gene microRNA 7034 Neighboring gene serine/threonine/tyrosine interacting-like 1 Neighboring gene predicted gene, 30205

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the Por gene: The Por gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs from Annotation Pipeline: 349 organisms have orthologs with human gene Por

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables FMN binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables FMN binding ISO
Inferred from Sequence Orthology
more info
 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables NADPH-hemoprotein reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NADPH-hemoprotein reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables cytochrome-b5 reductase activity, acting on NAD(P)H ISO
Inferred from Sequence Orthology
more info
 
enables electron transfer activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables iron-cytochrome-c reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables nitric oxide dioxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular organofluorine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in demethylation ISO
Inferred from Sequence Orthology
more info
 
involved_in electron transport chain ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid oxidation ISO
Inferred from Sequence Orthology
more info
 
involved_in internal peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in nitrate catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nitric oxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chondrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of monooxygenase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of growth plate cartilage chondrocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in response to dexamethasone ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NADPH--cytochrome P450 reductase
Names
NADH cytochrome P450 oxydoreductase
P450 (cytochrome) oxidoreductase
NP_032924.1
XP_006504461.1
XP_006504462.1
XP_036020784.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008898.2NP_032924.1  NADPH--cytochrome P450 reductase

    See identical proteins and their annotated locations for NP_032924.1

    Status: VALIDATED

    Source sequence(s)
    AC083948
    Consensus CDS
    CCDS39318.1
    UniProtKB/Swiss-Prot
    P37040
    Related
    ENSMUSP00000005651.7, ENSMUST00000005651.13
    Conserved Domains (2) summary
    cd06204
    Location:277677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:82219
    Flavodoxin_1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135698894..135764180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504399.1XP_006504462.1  NADPH--cytochrome P450 reductase isoform X2

    See identical proteins and their annotated locations for XP_006504462.1

    UniProtKB/Swiss-Prot
    P37040
    Conserved Domains (2) summary
    cd06204
    Location:277677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:82219
    Flavodoxin_1
  2. XM_006504398.1XP_006504461.1  NADPH--cytochrome P450 reductase isoform X2

    See identical proteins and their annotated locations for XP_006504461.1

    UniProtKB/Swiss-Prot
    P37040
    Conserved Domains (2) summary
    cd06204
    Location:277677
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:82219
    Flavodoxin_1
  3. XM_036164891.1XP_036020784.1  NADPH--cytochrome P450 reductase isoform X1

    Conserved Domains (2) summary
    cd06204
    Location:328728
    CYPOR; NADPH cytochrome p450 reductase (CYPOR) serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine synthase reductases. CYPOR transfers two electrons from NADPH to the heme of cytochrome p450 via ...
    pfam00258
    Location:133270
    Flavodoxin_1