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GPR85 G protein-coupled receptor 85 [ Homo sapiens (human) ]

Gene ID: 54329, updated on 24-Nov-2020

Summary

Official Symbol
GPR85provided by HGNC
Official Full Name
G protein-coupled receptor 85provided by HGNC
Primary source
HGNC:HGNC:4536
See related
Ensembl:ENSG00000164604 MIM:605188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SREB; SREB2
Summary
Members of the G protein-coupled receptor (GPCR) family, such as GPR85, have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli, such as neurotransmitters, hormones, or light, induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins (Matsumoto et al., 2000 [PubMed 10833454]).[supplied by OMIM, Aug 2008]
Expression
Biased expression in brain (RPKM 3.3), testis (RPKM 1.1) and 12 other tissues See more
Orthologs

Genomic context

See GPR85 in Genome Data Viewer
Location:
7q31.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (113081854..113087724, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (112720468..112727833, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene base methyltransferase of 25S rRNA 2 homolog Neighboring gene heart tissue-associated transcript 17 Neighboring gene uncharacterized LOC107986837 Neighboring gene small integral membrane protein 30 Neighboring gene protein phosphatase 1 regulatory subunit 3A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of G protein-coupled receptor 85 (GPR85) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ50993, FLJ51159, FLJ99433

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 85
Names
seven transmembrane helix receptor
super conserved receptor expressed in brain 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146265.2NP_001139737.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_001139737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC073346
    Consensus CDS
    CCDS5758.1
    UniProtKB/Swiss-Prot
    P60893
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Related
    ENSP00000297146.2, ENST00000297146.7
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001146266.2NP_001139738.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_001139738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC073346
    Consensus CDS
    CCDS5758.1
    UniProtKB/Swiss-Prot
    P60893
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Related
    ENSP00000401178.1, ENST00000449591.1
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_001146267.2NP_001139739.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_001139739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC073346
    Consensus CDS
    CCDS5758.1
    UniProtKB/Swiss-Prot
    P60893
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Related
    ENSP00000396763.1, ENST00000424100.1
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  4. NM_018970.7NP_061843.3  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_061843.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-4) encode the same protein.
    Source sequence(s)
    AC073346
    Consensus CDS
    CCDS5758.1
    UniProtKB/Swiss-Prot
    P60893
    UniProtKB/TrEMBL
    A4D0T8, Q8NEN2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    113081854..113087724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250451.2XP_005250508.1  probable G-protein coupled receptor 85 isoform X1

    See identical proteins and their annotated locations for XP_005250508.1

    UniProtKB/Swiss-Prot
    P60893
    UniProtKB/TrEMBL
    A4D0T8
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017012352.2XP_016867841.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60893
    UniProtKB/TrEMBL
    A4D0T8
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
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