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Gpr85 G protein-coupled receptor 85 [ Mus musculus (house mouse) ]

Gene ID: 64450, updated on 2-May-2024

Summary

Official Symbol
Gpr85provided by MGI
Official Full Name
G protein-coupled receptor 85provided by MGI
Primary source
MGI:MGI:1927851
See related
Ensembl:ENSMUSG00000048216 AllianceGenome:MGI:1927851
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2900026B03Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within signal transduction. Predicted to be located in endoplasmic reticulum. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal medulla; central nervous system; musculoskeletal system; peripheral nervous system ganglion; and trigeminal nerve. Orthologous to human GPR85 (G protein-coupled receptor 85). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 18.7), whole brain E14.5 (RPKM 12.1) and 5 other tissues See more
Orthologs
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Genomic context

See Gpr85 in Genome Data Viewer
Location:
6 A1; 6 5.76 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13834405..13839951, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13834406..13839942, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_15197 Neighboring gene base methyltransferase of 25S rRNA 2 Neighboring gene STARR-positive B cell enhancer ABC_E2186 Neighboring gene STARR-positive B cell enhancer ABC_E4812 Neighboring gene STARR-positive B cell enhancer mm9_chr6:13645143-13645444 Neighboring gene STARR-seq mESC enhancer starr_15198 Neighboring gene predicted gene, 53312 Neighboring gene STARR-seq mESC enhancer starr_15199 Neighboring gene STARR-seq mESC enhancer starr_15200 Neighboring gene STARR-seq mESC enhancer starr_15201 Neighboring gene STARR-seq mESC enhancer starr_15202 Neighboring gene STARR-seq mESC enhancer starr_15203 Neighboring gene STARR-seq mESC enhancer starr_15204 Neighboring gene RIKEN cDNA 1110019D14 gene Neighboring gene STARR-seq mESC enhancer starr_15205 Neighboring gene small integral membrane protein 30

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp761L08121

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 85
Names
super conserved receptor expressed in brain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330666.1NP_001317595.1  probable G-protein coupled receptor 85

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC113309, BC065154, BY125022
    Consensus CDS
    CCDS19916.1
    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001330667.1NP_001317596.1  probable G-protein coupled receptor 85

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC113309, BC065154, BY125022, CF738797
    Consensus CDS
    CCDS19916.1
    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  3. NM_145066.5NP_659503.1  probable G-protein coupled receptor 85

    See identical proteins and their annotated locations for NP_659503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AC113309, BC065154, BY125022
    Consensus CDS
    CCDS19916.1
    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Related
    ENSMUSP00000053837.8, ENSMUST00000060442.14
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    13834405..13839951 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152258.1XP_036008151.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Related
    ENSMUSP00000111154.2, ENSMUST00000115491.2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017321705.3XP_017177194.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  3. XM_030255527.2XP_030111387.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Related
    ENSMUSP00000111155.2, ENSMUST00000115492.2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  4. XM_011241079.4XP_011239381.1  probable G-protein coupled receptor 85 isoform X1

    See identical proteins and their annotated locations for XP_011239381.1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  5. XM_030255529.2XP_030111389.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  6. XM_030255528.2XP_030111388.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors
  7. XM_030255530.2XP_030111390.1  probable G-protein coupled receptor 85 isoform X1

    UniProtKB/Swiss-Prot
    P60894
    UniProtKB/TrEMBL
    Q6ZWR2
    Conserved Domains (1) summary
    cd15218
    Location:21350
    7tmA_SREB2_GPR85; super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors