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Kcnn1 potassium calcium-activated channel subfamily N member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 54261, updated on 18-Sep-2024

Summary

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Official Symbol
Kcnn1provided by RGD
Official Full Name
potassium calcium-activated channel subfamily N member 1provided by RGD
Primary source
RGD:2962
See related
EnsemblRapid:ENSRNOG00000029264 AllianceGenome:RGD:2962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SK1; SKCa1; KCa2.1
Summary
Enables small conductance calcium-activated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Located in neuronal cell body. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 27.2), Heart (RPKM 11.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16p14
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (18608782..18632571)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (18574858..18598585)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (20325270..20349163)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 5 Neighboring gene uncharacterized LOC134482469 Neighboring gene coiled-coil domain containing 124 Neighboring gene uncharacterized LOC134482468 Neighboring gene arrestin domain containing 2 Neighboring gene interleukin 12 receptor subunit beta 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease. Wang Y, et al. Mol Neurobiol, 2015 Feb. PMID 24841382
  2. Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats. Gui L, et al. Am J Physiol Regul Integr Comp Physiol, 2012 Aug 1. PMID 22647293, Free PMC Article
  3. Depletion of SK1 channel subunits leads to constitutive insulin secretion. Andres MA, et al. FEBS Lett, 2009 Jan 22. PMID 19101546
  4. Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity. D'hoedt D, et al. J Biol Chem, 2004 Mar 26. PMID 14761961
  5. Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization. Deng S, et al. Int J Biochem Cell Biol, 2019 Sep. PMID 31276786

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results indicate that ADSC-derived exosomes ameliorate cardiac damage after MI by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization.
    Title: Exosomes from adipose-derived mesenchymal stem cells ameliorate cardiac damage after myocardial infarction by activating S1P/SK1/S1PR1 signaling and promoting macrophage M2 polarization.
  2. rSK1 appears to act as chaperone for rSK2 channels and expression of rSK1 may control the level of functional SK current in rat neurons.
    Title: rSK1 in Rat Neurons: A Controller of Membrane rSK2?
  3. SK channel current is a substantial element in sustaining the substantia nigra pars compacta dopaminergic neuroal rhythmic pacemaking.
    Title: Firing pattern modulation through SK channel current increase underlies neuronal survival in an organotypic slice model of Parkinson's disease.
  4. This study demonistrated that SK1 and SK2 transcripts showed strong expression starting from E15 in the striatum and decreased throughout pre- and postnatal development.
    Title: Developmental mapping of small-conductance calcium-activated potassium channel expression in the rat nervous system.
  5. Small conductance Ca(2+)-activated K(+) (SK) channels expressed in the hypothalamic paraventricular nucleus play an important role in the regulation of sympathetic outflow and cardiovascular function.
    Title: Role of small conductance calcium-activated potassium channels expressed in PVN in regulating sympathetic nerve activity and arterial blood pressure in rats.
  6. expressed in myometrium throughout pregnancy and contribute to outward current, regulate membrane potential and calcium signalling
    Title: Distribution, expression and functional effects of small conductance Ca-activated potassium (SK) channels in rat myometrium.
  7. downregulation of SK1 and SK3 channels and upregulation of SK2 channels provide direct evidence that these Ca2+-activated K+ channels play important roles in inferior colliculi neuronal hyperexcitability that leads to inherited seizure susceptibility
    Title: Protein expression of small conductance calcium-activated potassium channels is altered in inferior colliculus neurons of the genetically epilepsy-prone rat.
  8. These results implicate SK1 subunits as key regulators of excitability and endocrine function in beta cells.
    Title: Depletion of SK1 channel subunits leads to constitutive insulin secretion.
  9. rSK1 subunit is synthesized in cells but does not form functional homomeric channels
    Title: Domain analysis of the calcium-activated potassium channel SK1 from rat brain. Functional expression and toxin sensitivity.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
  
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables small conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small conductance calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables small conductance calcium-activated potassium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables small conductance calcium-activated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables small conductance calcium-activated potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
small conductance calcium-activated potassium channel protein 1
Names
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019313.2 → NP_062186.1  small conductance calcium-activated potassium channel protein 1

    See identical proteins and their annotated locations for NP_062186.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/Swiss-Prot
    P70606
    UniProtKB/TrEMBL
    A0A8I6A039
    Related
    ENSRNOP00000042517.5, ENSRNOT00000044291.5
    Conserved Domains (3) summary
    smart01053
    Location:380 → 458
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:92 → 199
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:287 → 366
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    18608782..18632571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275667.1 → XP_063131737.1  small conductance calcium-activated potassium channel protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A039
    Related
    ENSRNOP00000108501.1, ENSRNOT00000142781.1

  2. XM_063275660.1 → XP_063131730.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77

  3. XM_039094789.2 → XP_038950717.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77
    Conserved Domains (3) summary
    smart01053
    Location:380 → 455
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:92 → 199
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:287 → 366
    Ion_trans_2; Ion channel

  4. XM_063275659.1 → XP_063131729.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77

  5. XM_063275663.1 → XP_063131733.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77

  6. XM_063275661.1 → XP_063131731.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77

  7. XM_063275662.1 → XP_063131732.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77

  8. XM_063275665.1 → XP_063131735.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77

  9. XM_063275664.1 → XP_063131734.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77

  10. XM_063275666.1 → XP_063131736.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77
    Related
    ENSRNOP00000073862.3, ENSRNOT00000080467.3

  11. XM_063275658.1 → XP_063131728.1  small conductance calcium-activated potassium channel protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A039, A0A8L2QL77

RNA

  1. XR_010058310.1 RNA Sequence

  2. XR_005494664.2 RNA Sequence

  3. XR_005494662.2 RNA Sequence

  4. XR_010058309.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70606.2 GenPept UniProtKB/Swiss-Prot:P70606

Gene LinkOut

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