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Kcnn1 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 [ Mus musculus (house mouse) ]

Gene ID: 84036, updated on 24-Oct-2019

Summary

Official Symbol
Kcnn1provided by MGI
Official Full Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1provided by MGI
Primary source
MGI:MGI:1933993
See related
Ensembl:ENSMUSG00000002908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SK1; KCa2.1; AI854248
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 4.8), CNS E14 (RPKM 4.3) and 26 other tissues See more
Orthologs

Genomic context

See Kcnn1 in Genome Data Viewer
Location:
8; 8 B3.3
Exon count:
13
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70843158..70865691, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (73365948..73380907, complement)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene interleukin 12 receptor, beta 1 Neighboring gene arrestin domain containing 2 Neighboring gene coiled-coil domain containing 124 Neighboring gene solute carrier family 5 (sodium iodide symporter), member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Clone Names

  • MGC115869

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium-activated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
small conductance calcium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small conductance calcium-activated potassium channel activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
ion transport IEA
Inferred from Electronic Annotation
more info
 
potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
potassium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
small conductance calcium-activated potassium channel protein 1
Names
SKCa 1
SKCa1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363407.1NP_001350336.1  small conductance calcium-activated potassium channel protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC162446, BC090622
    Consensus CDS
    CCDS52578.1
    Related
    ENSMUSP00000148544.1, ENSMUST00000212611.1
    Conserved Domains (4) summary
    smart01053
    Location:382460
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289368
    Ion_trans_2; Ion channel
    pfam13600
    Location:464497
    DUF4140; N-terminal domain of unknown function (DUF4140)
  2. NM_001363408.1NP_001350337.1  small conductance calcium-activated potassium channel protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC019302, AC162446
    Consensus CDS
    CCDS90413.1
    Related
    ENSMUSP00000148705.2, ENSMUST00000212509.2
    Conserved Domains (4) summary
    smart01053
    Location:382457
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289368
    Ion_trans_2; Ion channel
    pfam13600
    Location:461494
    DUF4140; N-terminal domain of unknown function (DUF4140)
  3. NM_032397.3NP_115773.2  small conductance calcium-activated potassium channel protein 1 isoform a

    See identical proteins and their annotated locations for NP_115773.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC019302, AC162446
    Consensus CDS
    CCDS52578.1
    UniProtKB/Swiss-Prot
    Q9EQR3
    UniProtKB/TrEMBL
    A0A140T8Q8
    Related
    ENSMUSP00000105705.3, ENSMUST00000110078.4
    Conserved Domains (4) summary
    smart01053
    Location:382460
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289368
    Ion_trans_2; Ion channel
    pfam13600
    Location:464497
    DUF4140; N-terminal domain of unknown function (DUF4140)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p6 C57BL/6J

    Range
    70843158..70865691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243866.1XP_030099726.1  small conductance calcium-activated potassium channel protein 1 isoform X2

  2. XM_030243865.1XP_030099725.1  small conductance calcium-activated potassium channel protein 1 isoform X2

  3. XM_006509808.4XP_006509871.1  small conductance calcium-activated potassium channel protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006509871.1

    UniProtKB/Swiss-Prot
    Q9EQR3
    UniProtKB/TrEMBL
    A0A140T8Q8
    Conserved Domains (4) summary
    smart01053
    Location:382460
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289368
    Ion_trans_2; Ion channel
    pfam13600
    Location:464497
    DUF4140; N-terminal domain of unknown function (DUF4140)
  4. XM_006509806.2XP_006509869.2  small conductance calcium-activated potassium channel protein 1 isoform X1

    Conserved Domains (3) summary
    smart01053
    Location:352423
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:94201
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:289351
    Ion_trans_2; Ion channel

RNA

  1. XR_003947357.1 RNA Sequence

  2. XR_870467.2 RNA Sequence

  3. XR_379049.2 RNA Sequence

Reference GRCm38.p6 PATCHES

Genomic

  1. NW_016097320.1 Reference GRCm38.p6 PATCHES

    Range
    169329..170728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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