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KCNN1 potassium calcium-activated channel subfamily N member 1 [ Homo sapiens (human) ]

Gene ID: 3780, updated on 6-Sep-2021

Summary

Official Symbol
KCNN1provided by HGNC
Official Full Name
potassium calcium-activated channel subfamily N member 1provided by HGNC
Primary source
HGNC:HGNC:6290
See related
Ensembl:ENSG00000105642 MIM:602982
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SK1; hSK1; SKCA1; KCa2.1
Summary
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 5.8), testis (RPKM 0.7) and 1 other tissue See more
Orthologs
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Genomic context

See KCNN1 in Genome Data Viewer
Location:
19p13.11
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17951290..18000085)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18062099..18110894)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 5 member 5 Neighboring gene coiled-coil domain containing 124 Neighboring gene RNA, 5S ribosomal pseudogene 468 Neighboring gene arrestin domain containing 2 Neighboring gene CS pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 (KCNN1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
involved_in ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
part_of voltage-gated potassium channel complex TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
small conductance calcium-activated potassium channel protein 1
Names
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
small conductance calcium-activated potassium channel 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029893.1 RefSeqGene

    Range
    5001..52820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001386974.1NP_001373903.1  small conductance calcium-activated potassium channel protein 1 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC020904
    Related
    ENSP00000507021.1, ENST00000684775.1
    Conserved Domains (3) summary
    smart01053
    Location:384461
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:96203
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:291370
    Ion_trans_2; Ion channel
  2. NM_001386975.1NP_001373904.1  small conductance calcium-activated potassium channel protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC020904
    Related
    ENSP00000507977.1, ENST00000683588.1
    Conserved Domains (3) summary
    smart01053
    Location:387464
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:96203
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:291373
    Ion_trans_2; Ion channel
  3. NM_001386976.1NP_001373905.1  small conductance calcium-activated potassium channel protein 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC005602, AC020904
    Related
    ENSP00000507255.1, ENST00000682733.1
    Conserved Domains (3) summary
    smart01053
    Location:387464
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:96203
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:291373
    Ion_trans_2; Ion channel
  4. NM_001386977.1NP_001373906.1  small conductance calcium-activated potassium channel protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC020904
    Related
    ENSP00000507047.1, ENST00000682421.1
    Conserved Domains (3) summary
    smart01053
    Location:384458
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:96203
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:291370
    Ion_trans_2; Ion channel
  5. NM_002248.5NP_002239.2  small conductance calcium-activated potassium channel protein 1 isoform 1

    See identical proteins and their annotated locations for NP_002239.2

    Status: REVIEWED

    Source sequence(s)
    AC005602, AC020904
    Consensus CDS
    CCDS67611.1
    UniProtKB/Swiss-Prot
    Q92952
    Related
    ENSP00000476519.1, ENST00000222249.13
    Conserved Domains (3) summary
    smart01053
    Location:384461
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:96203
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:291370
    Ion_trans_2; Ion channel

RNA

  1. NR_170373.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020904
    Related
    ENST00000683930.1
  2. NR_170374.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020904
    Related
    ENST00000682726.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17951290..18000085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528004.1XP_011526306.1  small conductance calcium-activated potassium channel protein 1 isoform X3

    Related
    ENSP00000484926.2, ENST00000615435.2
    Conserved Domains (4) summary
    pfam02888
    Location:470542
    CaMBD; Calmodulin binding domain
    pfam03530
    Location:179286
    SK_channel; Calcium-activated SK potassium channel
    pfam07885
    Location:374456
    Ion_trans_2; Ion channel
    pfam15240
    Location:35146
    Pro-rich; Proline-rich
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