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PNLIPRP1 pancreatic lipase related protein 1 [ Homo sapiens (human) ]

Gene ID: 5407, updated on 7-Jun-2020

Summary

Official Symbol
PNLIPRP1provided by HGNC
Official Full Name
pancreatic lipase related protein 1provided by HGNC
Primary source
HGNC:HGNC:9156
See related
Ensembl:ENSG00000187021 MIM:604422
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLRP1
Expression
Restricted expression toward pancreas (RPKM 974.1) See more
Orthologs

Genomic context

See PNLIPRP1 in Genome Data Viewer
Location:
10q25.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (116590959..116609175)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118350478..118368687)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene pancreatic lipase Neighboring gene pancreatic lipase pseudogene 1 Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene chromosome 10 open reading frame 82 Neighboring gene uncharacterized LOC105378499

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT lipase activity IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride lipase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
PubMed 
NOT extracellular space IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
inactive pancreatic lipase-related protein 1
NP_001290064.1
NP_006220.1
XP_011538171.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303135.1NP_001290064.1  inactive pancreatic lipase-related protein 1 precursor

    See identical proteins and their annotated locations for NP_001290064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK130236, BC025784, BP323340, CD622211
    Consensus CDS
    CCDS7595.1
    UniProtKB/Swiss-Prot
    P54315
    Related
    ENSP00000433933.1, ENST00000528052.5
    Conserved Domains (3) summary
    cd00707
    Location:52349
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:356467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18353
    Lipase; Lipase
  2. NM_006229.4NP_006220.1  inactive pancreatic lipase-related protein 1 precursor

    See identical proteins and their annotated locations for NP_006220.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC005233, BC025784, CD622211, M93283
    Consensus CDS
    CCDS7595.1
    UniProtKB/Swiss-Prot
    P54315
    Related
    ENSP00000351695.4, ENST00000358834.9
    Conserved Domains (3) summary
    cd00707
    Location:52349
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:356467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18353
    Lipase; Lipase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    116590959..116609175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539869.1XP_011538171.1  inactive pancreatic lipase-related protein 1 isoform X1

    Conserved Domains (3) summary
    cd00707
    Location:1200
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01759
    Location:207318
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:1204
    Lipase; Lipase

RNA

  1. XR_945774.2 RNA Sequence

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