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Pnliprp1 pancreatic lipase related protein 1 [ Mus musculus (house mouse) ]

Gene ID: 18946, updated on 18-Apr-2024

Summary

Official Symbol
Pnliprp1provided by MGI
Official Full Name
pancreatic lipase related protein 1provided by MGI
Primary source
MGI:MGI:97723
See related
Ensembl:ENSMUSG00000042179 AllianceGenome:MGI:97723
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plrp1
Summary
Predicted to enable lipase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Orthologous to human PNLIPRP1 (pancreatic lipase related protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 301.3), spleen adult (RPKM 164.9) and 4 other tissues See more
Orthologs
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Genomic context

Location:
19 D2; 19 54.49 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (58717319..58732601)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (58728887..58744169)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1810035K13 gene Neighboring gene RIKEN cDNA 1810018F18 gene Neighboring gene STARR-seq mESC enhancer starr_46584 Neighboring gene pancreatic lipase-related protein 2 Neighboring gene predicted gene, 52394

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables triglyceride lipase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
inactive pancreatic lipase-related protein 1
Names
PL-RP1
NP_061362.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018874.2NP_061362.1  inactive pancreatic lipase-related protein 1 precursor

    See identical proteins and their annotated locations for NP_061362.1

    Status: PROVISIONAL

    Source sequence(s)
    AF061274
    Consensus CDS
    CCDS29931.1
    UniProtKB/Swiss-Prot
    O70478, Q5BKQ4, Q6NV82
    Related
    ENSMUSP00000045465.6, ENSMUST00000048644.6
    Conserved Domains (2) summary
    cd01759
    Location:356467
    PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...
    pfam00151
    Location:18353
    Lipase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    58717319..58732601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)