1BU8,1GPL,1RP1,1LPB,1HPL,1ETH


Conserved Protein Domain Family
Pancreat_lipase_like

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cd00707: Pancreat_lipase_like 
Click on image for an interactive view with Cn3D
Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site.
Statistics
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PSSM-Id: 238363
Aligned: 51 rows
Threshold Bit Score: 257.942
Threshold Setting Gi: 21064559
Created: 24-Sep-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic triad [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1BU8_A     35 IDTRFLLYT-----NENPNNYQKISat---epDTIKFSNFQldrKTRFIVHGFIDKgeDGWLLDMCKKMFqvekVNCICV 106 Norway rat
1HPL_A     35 VNTRFLLYT-----NENPDNFQEIVad----pSTIQSSNFNtgrKTRFIIHGFIDKgeESWLSTMCQNMFkvesVNCICV 105 horse
NP_609175 104 SSSSADFWId----ENNFEFPQRHKrd----tWQEMAEKFNpelDTKILVHGWKSStmSNSIQSIRGAYIergqVNVFAI 175 fruit fly
NP_609814  75 PDVKYYIYT-----RHNPMDRQCLHideslekSNLTDSYFNpryPTKIIIHGYNSDmfLHPLQQMREEYLakadYNIIYV 149 fruit fly
NP_647821  12 LCQFLGLHAalldsLLNQSTIYYLKpsa--dvSLENVEQLSsveSVKLIVHGYLGSctHGSIMPLRNAYTaqgyENVLVA 89  fruit fly
EAA10466  574 VQFTGAWWYrs--cADRTLKQEMDVe------SFVPPPQLDlrrQLKVLIHGWNADrhHVSILPIRTAYLvqdaHNLLVA 645 Anopheles gambiae ...
NP_608682  47 PKIQFYLYT-----RRTQEQPEFIDvl---dpNALYYTHFNprhPTKIIIHGFGGGrtLSPSPDLREAYFsvgeYNIIIV 118 fruit fly
NP_722809   2 GYEVDCLAT-----FVDSTRENPILld----pLDLNPWNFQpprPLKILIHGYTGDrdFAPNSYIRPVLLdhedVYVISI 72  fruit fly
XP_396055  21 QNVFLRLYN-----SNGSYIDENIRn------ASLFLPYIQknnLLIILIHGFTEDinSYDIKIMTNAYLentqHNIFLI 89  honey bee
NP_723380  23 TTAKFILYYgp-tvADSDIYDLTDFq------SLLEDEHLDlgkNTVLYLHGYLEDpdVESIHVIAEAYLerkdTNLIVL 95  fruit fly
Feature 1                                                      #                             #
1BU8_A    107 DWRRG-SRTEYTQASYNTRVVGAEIAFLVQVLStem-gySPENVHLIGHSLGAHVVGEAGRRLeg------hVGRITGLD 178 Norway rat
1HPL_A    106 DWKSG-SRTAYSQASQNVRIVGAEVAYLVGVLQssf-dySPSNVHIIGHSLGSHAAGEAGRRTng------aVGRITGLD 177 horse
NP_609175 176 NWKDQaDNIYYLTPARYTVQVGRAVAKLIDLLVeek-daDPNRIHLIGHSLGAHIMGYAGSYTky------rVNRITGLD 248 fruit fly
NP_609814 150 DWSILsPGPCYISAVHNTKHAGTCTAQLVERLVe----tGNTDIHVIGFSLGAQVPNYIARNLss-----fmLPRITGLD 220 fruit fly
NP_647821  90 DWGPV-ANLDYPSSRLAVKNVAQILAKLLEEFLqrh-giSLEGVHVIGHSLGAHIAGRIGRYFng------sLGRVTGLD 161 fruit fly
EAA10466  646 DWSPA-AVLHYPTARDLVLPVGNHLGSILARFMkrl-giEPSQVHVIGHSLGAHIAGNVGRYLgg------kVRRVTALD 717 Anopheles gambiae ...
NP_608682 119 DYADAvKEPCLSQMDWAPRFGSLCISQLVKYLArhprgvQPDDLHFIGYSVGAHIAGLVANYLkpe---egkLGRITALD 195 fruit fly
NP_722809  73 DYGPLvRYPCYIQAVQNLPLVSRCLAQLINNLVdra-ivANDQIHLIGFSLGGQVAGQTANYVkr------kMKRITGLD 145 fruit fly
XP_396055  90 DYRNV-SKESYIFAEQDINKIGKSMADALDDMIen--gvNFKKIHIIGISLGAQLAGIIGRNMny------kIGRITGLD 160 honey bee
NP_723380  96 DWGELaDGNYMFDAFPNLKQLGPELAKVLLKMFdh--glDIEKFHIVGHSMGGQLAGLLGREItkrtkgvrkIKRISALD 173 fruit fly
Feature 1                                                                                     
1BU8_A    179 PAEPcfqgl-peevRLDPSDAMFVDVIHTDSApiipylgfGMSQKVGHLDFFPNGGKe-MPGCQknilstivdin----- 251 Norway rat
1HPL_A    178 PAEPcfqgt-pelvRLDPSDAQFVDVIHTDIApfipnlgfGMSQTAGHLDFFPNGGKe-MPGCQknvlsqivdid----- 250 horse
NP_609175 249 PARPafedcigpenHLDDTDANFVDVIHSCAGy------lGFRKPIGMVDFYPNGGGppQPGCKelsqifskfwelvsis 322 fruit fly
NP_609814 221 PAMPlfits-gkadKLDPSDASYVDVIHTNALv------qGKMERCGHADFYMNGGIm-QPGCNgqki------------ 280 fruit fly
NP_647821 162 PALPlfss--rsddSLHSNAAQFVDVIHTDYPl------fGDIRPRGTVDFYPNFGLapQPGCEnvdvvaas-------- 225 fruit fly
EAA10466  718 PAGPlfal--dskdAVGPDTAQFVDVIHTDGMt------lGENIVRGHADFFPNGGTppQPGCEtldv------------ 777 Anopheles gambiae ...
NP_608682 196 PTIFfyaga-nnsrDLDSTDAHFVDVLHTGAGi------lGQWHSSGHADFYVNGGTr-QPACVgsatl----------- 256 fruit fly
NP_722809 146 PAKPlfilg-pdsrRLDKGDADFVDVIHTDVFg------rGYLRAAGHVDFYPNFGAk-QPGCMeenm------------ 205 fruit fly
XP_396055 161 PVGPgyyi---lntHLSASDAEFVDIIHTDMGi------yGLALKIGHVDFFPNYGYrpQPGCPisen------------ 219 honey bee
NP_723380 174 PAFPlfy----pgtHLSANDAEFVDVIHTDAWl------yGAPTSTGTADFWPNGGYslQPGCPkrnykm---------- 233 fruit fly
Feature 1                     #                                                               
1BU8_A    252 ---giwegtqnfvACNHLRSYKYYASSIl--nPDGFLGYPCssyek--fqqndCFPCpe---------egCPKMGHYADQ 315 Norway rat
1HPL_A    251 ---giwqgtrdfaACNHLRSYKYYTDSIl--nPDGFAGFSCasysd--ftankCFPCss---------egCPQMGHYADR 314 horse
NP_609175 323 ykqnweisfsfsaGCSHGRSYEYYAESIn--sPKGFYGVPCsglde--lkgknCTGG-------------KILMGDPVPR 385 fruit fly
NP_609814 281 ----------nsfACSHQRAPAYFLESIr--sPKGFWGWACsgyis--yllgmCPPTn-----------fLLEAGENIRP 335 fruit fly
NP_647821 226 ------kllheaySCSHNRAVMFYAESIg--mPENFPAVSCsltaiksrrvedCLREksktntenandyqTVFMGEHVNR 297 fruit fly
EAA10466  778 ---------ftlhSCSHARSTGFFAESIp--lPNSFVACACsrdeis-rqadiCLPDvrdt-----ssreCVAMGEALEL 840 Anopheles gambiae ...
NP_608682 257 ---------fqtlACDHTKVTPYFIESIt--tTRGFYAGPCpnlfs--yligwCEPKds----------eYVLMGEHCSH 313 fruit fly
NP_722809 206 ---------qdpsSCNHERAPRFYAESIn--tTVGFWARQCsgwll--qlltlCPTTg-----------aQALLGYHVSD 261 fruit fly
XP_396055 220 ---------ditrFCSHGRSIEFYVESIk---NSTAFIGKCefys-----lneCNIE-------------YIPMGYATPH 269 honey bee
NP_723380 234 --------lsdndLSSHRRSWWFWAESVsdryPIGFDAVPAkk--------wsDFKQnkiv-----encpPVVMGHHCPT 292 fruit fly
Feature 1                       
1BU8_A    316 fegktatveqtVYLNTGD 333 Norway rat
1HPL_A    315 fpgrtkgvgqlFYLNTGD 332 horse
NP_609175 386 ear------giFFVKTAN 397 fruit fly
NP_609814 336 ttr------gmFMIDTND 347 fruit fly
NP_647821 298 rswna-vnlgiSRWQQLA 314 fruit fly
EAA10466  841 rsqra-arirpGSRPTQS 857 Anopheles gambiae str. PEST
NP_608682 314 kar------gnYYVTTNA 325 fruit fly
NP_722809 262 elr------gsYFLQTAS 273 fruit fly
XP_396055 270 nan------gnYYLITNS 281 honey bee
NP_723380 293 tih------gdFYLQTNG 304 fruit fly

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