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PTPRM protein tyrosine phosphatase receptor type M [ Bos taurus (domestic cattle) ]

Gene ID: 536092, updated on 17-Aug-2024

Summary

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Official Symbol
PTPRMprovided by VGNC
Official Full Name
protein tyrosine phosphatase receptor type Mprovided by VGNC
Primary source
VGNC:VGNC:33553
See related
BGD:BT25796; Ensembl:ENSBTAG00000024015
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 24
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 24 NC_037351.1 (40330021..40995221)

Chromosome 24 - NC_037351.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 30 Neighboring gene serine/arginine-rich splicing factor 12-like Neighboring gene uncharacterized LOC132343775 Neighboring gene microRNA mir-2285o-4 Neighboring gene RAB12, member RAS oncogene family Neighboring gene uncharacterized LOC107131785 Neighboring gene microtubule crosslinking factor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037351.1 Chromosome 24 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase mu
XP_005224353.1
XP_010817253.1
XP_024840256.1
XP_024840257.1
XP_059737024.1
XP_059737025.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037351.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    40330021..40995221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059881042.1 → XP_059737025.1  receptor-type tyrosine-protein phosphatase mu isoform X6

  2. XM_024984488.2 → XP_024840256.1  receptor-type tyrosine-protein phosphatase mu isoform X1

    Conserved Domains (7) summary
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:908 → 1178
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1240 → 1472
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:383 → 477
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain
    pfam00041
    Location:499 → 574
    fn3; Fibronectin type III domain

  3. XM_024984489.2 → XP_024840257.1  receptor-type tyrosine-protein phosphatase mu isoform X3

    Related
    ENSBTAP00000073905.2, ENSBTAT00000071236.2
    Conserved Domains (7) summary
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:908 → 1161
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1223 → 1455
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:383 → 477
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain
    pfam00041
    Location:499 → 574
    fn3; Fibronectin type III domain

  4. XM_010818951.4 → XP_010817253.1  receptor-type tyrosine-protein phosphatase mu isoform X2

    UniProtKB/TrEMBL
    E1BPU9
    Related
    ENSBTAP00000053345.4, ENSBTAT00000061002.4
    Conserved Domains (9) summary
    cd06263
    Location:27 → 182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:899 → 1169
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192 → 278
    IG_like; Immunoglobulin like
    cd00047
    Location:926 → 1169
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499 → 581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain
    pfam15820
    Location:726 → 815
    ECSCR; Endothelial cell-specific chemotaxis regulator

  5. XM_005224296.5 → XP_005224353.1  receptor-type tyrosine-protein phosphatase mu isoform X4

    See identical proteins and their annotated locations for XP_005224353.1

    UniProtKB/TrEMBL
    E1BPU9
    Conserved Domains (9) summary
    cd06263
    Location:27 → 182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282 → 361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:899 → 1152
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192 → 278
    IG_like; Immunoglobulin like
    cd00047
    Location:926 → 1152
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499 → 581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain
    pfam15820
    Location:726 → 815
    ECSCR; Endothelial cell-specific chemotaxis regulator

  6. XM_059881041.1 → XP_059737024.1  receptor-type tyrosine-protein phosphatase mu isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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