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PTPRM protein tyrosine phosphatase receptor type M [ Homo sapiens (human) ]

Gene ID: 5797, updated on 22-Aug-2021

Summary

Official Symbol
PTPRMprovided by HGNC
Official Full Name
protein tyrosine phosphatase receptor type Mprovided by HGNC
Primary source
HGNC:HGNC:9675
See related
Ensembl:ENSG00000173482 MIM:176888
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU
Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Expression
Broad expression in fat (RPKM 28.8), thyroid (RPKM 25.6) and 23 other tissues See more
Orthologs
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Genomic context

See PTPRM in Genome Data Viewer
Location:
18p11.23
Exon count:
41
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (7567316..8406859)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (7567314..8406854)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112577592 Neighboring gene uncharacterized LOC105371976 Neighboring gene uncharacterized LOC107985119 Neighboring gene uncharacterized LOC100192426 Neighboring gene COP1 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 50, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation.
GeneReviews: Not available
Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC166994

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cadherin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase mu
Names
protein tyrosine phosphatase mu
protein tyrosine phosphatase, receptor type, mu polypeptide
NP_001098714.1
NP_001365071.1
NP_001365072.1
NP_001365073.1
NP_001365074.1
NP_001365075.1
NP_001365076.1
NP_002836.3
XP_011524010.1
XP_011524012.1
XP_011524014.1
XP_011524015.1
XP_011524019.1
XP_016881383.1
XP_016881384.1
XP_016881385.1
XP_016881386.1
XP_016881387.1
XP_016881388.1
XP_016881389.1
XP_016881390.1
XP_016881391.1
XP_016881392.1
XP_016881393.1
XP_016881394.1
XP_016881398.1
XP_016881399.1
XP_016881400.1
XP_016881401.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105244.2NP_001098714.1  receptor-type tyrosine-protein phosphatase mu isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP000897, AP001091, AP001094, AP005118, AP005227, AP005900
    Consensus CDS
    CCDS58613.1
    UniProtKB/Swiss-Prot
    P28827
    Related
    ENSP00000463325.1, ENST00000580170.6
    Conserved Domains (8) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9121166
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9391166
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192274
    ig; Immunoglobulin domain
  2. NM_001378142.1NP_001365071.1  receptor-type tyrosine-protein phosphatase mu isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    Conserved Domains (7) summary
    smart00060
    Location:69148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:671943
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:10291234
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286361
    fn3; Fibronectin type III domain
    pfam00047
    Location:1961
    ig; Immunoglobulin domain
    pfam18861
    Location:443550
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
  3. NM_001378143.1NP_001365072.1  receptor-type tyrosine-protein phosphatase mu isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    Conserved Domains (7) summary
    smart00060
    Location:69148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:684956
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:10421247
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286361
    fn3; Fibronectin type III domain
    pfam00047
    Location:1961
    ig; Immunoglobulin domain
    pfam18861
    Location:443550
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
  4. NM_001378144.1NP_001365073.1  receptor-type tyrosine-protein phosphatase mu isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    Conserved Domains (6) summary
    smart00060
    Location:69148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:696968
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:10541259
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286361
    fn3; Fibronectin type III domain
    pfam00047
    Location:1961
    ig; Immunoglobulin domain
  5. NM_001378145.1NP_001365074.1  receptor-type tyrosine-protein phosphatase mu isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    Conserved Domains (5) summary
    smart00060
    Location:170254
    FN3; Fibronectin type 3 domain
    cd14633
    Location:709981
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:10671272
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286361
    fn3; Fibronectin type III domain
    pfam00047
    Location:1961
    ig; Immunoglobulin domain
  6. NM_001378146.1NP_001365075.1  receptor-type tyrosine-protein phosphatase mu isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    Conserved Domains (7) summary
    smart00060
    Location:69148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:684973
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:10591264
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286361
    fn3; Fibronectin type III domain
    pfam00047
    Location:1961
    ig; Immunoglobulin domain
    pfam18861
    Location:443550
    PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J
  7. NM_001378147.1NP_001365076.1  receptor-type tyrosine-protein phosphatase mu isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP001094, AP005118, AP005227, AP005900
    Conserved Domains (6) summary
    smart00060
    Location:69148
    FN3; Fibronectin type 3 domain
    cd00063
    Location:170264
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14633
    Location:709998
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:10841289
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:286361
    fn3; Fibronectin type III domain
    pfam00047
    Location:1961
    ig; Immunoglobulin domain
  8. NM_002845.4NP_002836.3  receptor-type tyrosine-protein phosphatase mu isoform 2 precursor

    See identical proteins and their annotated locations for NP_002836.3

    Status: REVIEWED

    Source sequence(s)
    AC006566, AP000897, AP001091, AP001094, AP005118, AP005227, AP005900
    Consensus CDS
    CCDS11840.1
    UniProtKB/Swiss-Prot
    P28827
    Related
    ENSP00000331418.8, ENST00000332175.12
    Conserved Domains (8) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8991153
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9261153
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192274
    ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    7567316..8406859
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525708.2XP_011524010.1  receptor-type tyrosine-protein phosphatase mu isoform X7

    Conserved Domains (8) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9371208
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9641208
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192274
    ig; Immunoglobulin domain
  2. XM_011525710.2XP_011524012.1  receptor-type tyrosine-protein phosphatase mu isoform X11

    Conserved Domains (8) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9371191
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9641191
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192274
    ig; Immunoglobulin domain
  3. XM_011525712.2XP_011524014.1  receptor-type tyrosine-protein phosphatase mu isoform X13

    Conserved Domains (8) summary
    cd06263
    Location:27182
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:282361
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:9121183
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:192278
    IG_like; Immunoglobulin like
    cd00047
    Location:9391183
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:499581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:192274
    ig; Immunoglobulin domain
  4. XM_017025911.1XP_016881400.1  receptor-type tyrosine-protein phosphatase mu isoform X26

  5. XM_017025894.1XP_016881383.1  receptor-type tyrosine-protein phosphatase mu isoform X1

  6. XM_017025897.1XP_016881386.1  receptor-type tyrosine-protein phosphatase mu isoform X4

  7. XM_017025895.1XP_016881384.1  receptor-type tyrosine-protein phosphatase mu isoform X2

  8. XM_017025898.1XP_016881387.1  receptor-type tyrosine-protein phosphatase mu isoform X5

  9. XM_017025896.1XP_016881385.1  receptor-type tyrosine-protein phosphatase mu isoform X3

  10. XM_017025900.1XP_016881389.1  receptor-type tyrosine-protein phosphatase mu isoform X8

  11. XM_017025899.1XP_016881388.1  receptor-type tyrosine-protein phosphatase mu isoform X6

  12. XM_017025902.1XP_016881391.1  receptor-type tyrosine-protein phosphatase mu isoform X10

  13. XM_017025903.1XP_016881392.1  receptor-type tyrosine-protein phosphatase mu isoform X12

  14. XM_017025901.1XP_016881390.1  receptor-type tyrosine-protein phosphatase mu isoform X9

  15. XM_017025904.1XP_016881393.1  receptor-type tyrosine-protein phosphatase mu isoform X14

    Related
    ENSP00000382927.4, ENST00000400053.8
  16. XM_017025912.1XP_016881401.1  receptor-type tyrosine-protein phosphatase mu isoform X27

  17. XM_017025910.1XP_016881399.1  receptor-type tyrosine-protein phosphatase mu isoform X25

  18. XM_011525713.2XP_011524015.1  receptor-type tyrosine-protein phosphatase mu isoform X15

    Conserved Domains (8) summary
    cd06263
    Location:1120
    MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
    smart00060
    Location:220299
    FN3; Fibronectin type 3 domain
    smart00137
    Location:1120
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:8751146
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00410
    Location:130216
    IG_like; Immunoglobulin like
    cd00047
    Location:9021146
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:437519
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00047
    Location:130212
    ig; Immunoglobulin domain
  19. XM_017025905.1XP_016881394.1  receptor-type tyrosine-protein phosphatase mu isoform X16

  20. XM_017025909.1XP_016881398.1  receptor-type tyrosine-protein phosphatase mu isoform X22

  21. XM_011525717.2XP_011524019.1  receptor-type tyrosine-protein phosphatase mu isoform X24

    Conserved Domains (3) summary
    smart00194
    Location:558829
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:585829
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00063
    Location:120202
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RNA

  1. XR_001753258.1 RNA Sequence

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