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IRAK1 interleukin 1 receptor associated kinase 1 [ Bos taurus (domestic cattle) ]

Gene ID: 533953, updated on 17-Aug-2024

Summary

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Official Symbol
IRAK1provided by VGNC
Official Full Name
interleukin 1 receptor associated kinase 1provided by VGNC
Primary source
VGNC:VGNC:30264
See related
BGD:BT11504; Ensembl:ENSBTAG00000016085
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: X
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (37212624..37220214, complement)

Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112445094 Neighboring gene transmembrane protein 187 Neighboring gene methyl-CpG binding protein 2 Neighboring gene elongation factor 2-like Neighboring gene opsin 1, long wave sensitive

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of novel transcripts putatively relevant for bovine fat metabolism. Eberlein A, et al. Mol Biol Rep, 2011 Jun. PMID 20127178
  2. Cloning and radiation hybrid mapping of bovine toll-like receptor-4 (TLR-4) signaling molecules. Connor EE, et al. Vet Immunol Immunopathol, 2006 Aug 15. PMID 16621030
  3. Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis. Moyes KM, et al. Funct Integr Genomics, 2010 Mar. PMID 20072847
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results describe a new full-length gene model for the bovine IRAK1 gene.
    Title: Annotation of novel transcripts putatively relevant for bovine fat metabolism.
  2. ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows.
    Title: Greater expression of TLR2, TLR4, and IL6 due to negative energy balance is associated with lower expression of HLA-DRA and HLA-A in bovine blood neutrophils after intramammary mastitis challenge with Streptococcus uberis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-1 receptor-associated kinase 1
Names
IRAK-1
NP_001035645.1
XP_024843880.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040555.1 → NP_001035645.1  interleukin-1 receptor-associated kinase 1

    See identical proteins and their annotated locations for NP_001035645.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ319075
    UniProtKB/Swiss-Prot
    Q2LGB3
    UniProtKB/TrEMBL
    D3WYX4, Q32PF8
    Conserved Domains (3) summary
    smart00219
    Location:217 → 518
    TyrKc; Tyrosine kinase, catalytic domain
    cd08794
    Location:17 → 100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:218 → 521
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    37212624..37220214 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024988112.2 → XP_024843880.1  interleukin-1 receptor-associated kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0AAF6Z257
    Related
    ENSBTAP00000021407.5, ENSBTAT00000021407.5
    Conserved Domains (3) summary
    cd08794
    Location:17 → 100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:218 → 521
    PKc_like; Protein Kinases, catalytic domain
    cl26464
    Location:480 → 746
    Atrophin-1; Atrophin-1 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2LGB3.2 GenPept UniProtKB/Swiss-Prot:Q2LGB3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.