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IRAK1 interleukin 1 receptor associated kinase 1 [ Homo sapiens (human) ]

Gene ID: 3654, updated on 9-Dec-2024

Summary

Official Symbol
IRAK1provided by HGNC
Official Full Name
interleukin 1 receptor associated kinase 1provided by HGNC
Primary source
HGNC:HGNC:6112
See related
Ensembl:ENSG00000184216 MIM:300283; AllianceGenome:HGNC:6112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRAK; pelle
Summary
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 25.0), appendix (RPKM 19.5) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See IRAK1 in Genome Data Viewer
Location:
Xq28
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154010507..154019902, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152284194..152293583, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153275958..153285353, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene host cell factor C1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:153234675-153234853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153235869-153236718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21079 Neighboring gene HCFC1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30047 Neighboring gene transmembrane protein 187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30048 Neighboring gene CRISPRi-validated cis-regulatory element chrX.2695 Neighboring gene microRNA 3202-1 Neighboring gene microRNA 3202-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153265676-153266176 Neighboring gene NFE2L2 motif-containing MPRA enhancer 190/191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153277410-153278394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153278395-153279378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153285318-153286287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153297889-153298431 Neighboring gene microRNA 718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153298432-153298975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153298976-153299518 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chrX:153301355-153301920 Neighboring gene methyl-CpG binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153306499-153306999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21083 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:153362776-153363014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21085

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with IRAK1 promoter to downregulate IRAK1 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
NOT enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 
involved_in interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-33-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 2 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
involved_in toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IC
Inferred by Curator
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-1 receptor-associated kinase 1
Names
Pelle homolog
NP_001020413.1
NP_001020414.1
NP_001397630.1
NP_001560.2
XP_047298053.1
XP_047298054.1
XP_054183009.1
XP_054183010.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008387.1 RefSeqGene

    Range
    4990..14385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025242.2NP_001020413.1  interleukin-1 receptor-associated kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001020413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AF346607, BC014963, BC054000, L76191, U52112
    Consensus CDS
    CCDS35444.1
    UniProtKB/Swiss-Prot
    P51617
    Related
    ENSP00000377291.2, ENST00000393687.6
    Conserved Domains (3) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    pfam07714
    Location:217513
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:218513
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001025243.2NP_001020414.1  interleukin-1 receptor-associated kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_001020414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon, as compared to variant 1. The encoded isoform 3 thus lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC014963, BC054000, BE276817, L76191, U52112
    Consensus CDS
    CCDS35443.1
    UniProtKB/Swiss-Prot
    P51617
    Related
    ENSP00000358991.2, ENST00000369974.6
    Conserved Domains (2) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:218434
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001410701.1NP_001397630.1  interleukin-1 receptor-associated kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    U52112
    Consensus CDS
    CCDS94700.1
    UniProtKB/TrEMBL
    D3YTB5
    Related
    ENSP00000392662.2, ENST00000429936.6
  4. NM_001569.4NP_001560.2  interleukin-1 receptor-associated kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001560.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC014963, BC054000, BE276817, L76191, U52112
    Consensus CDS
    CCDS14740.1
    UniProtKB/Swiss-Prot
    D3DWW3, D3DWW4, P51617, Q7Z5V4, Q96C06, Q96RL2
    Related
    ENSP00000358997.3, ENST00000369980.8
    Conserved Domains (3) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    pfam00069
    Location:212514
    Pkinase; Protein kinase domain
    cl21453
    Location:218521
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154010507..154019902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442098.1XP_047298054.1  interleukin-1 receptor-associated kinase 1 isoform X2

  2. XM_047442097.1XP_047298053.1  interleukin-1 receptor-associated kinase 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152284194..152293583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327035.1XP_054183010.1  interleukin-1 receptor-associated kinase 1 isoform X2

  2. XM_054327034.1XP_054183009.1  interleukin-1 receptor-associated kinase 1 isoform X1