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IRAK1 interleukin 1 receptor associated kinase 1 [ Homo sapiens (human) ]

Gene ID: 3654, updated on 6-Jul-2026
Official Symbol
IRAK1provided by HGNC
Official Full Name
interleukin 1 receptor associated kinase 1provided by HGNC
Primary source
HGNC:HGNC:6112
See related
Ensembl:ENSG00000184216 MIM:300283; AllianceGenome:HGNC:6112
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRAK; pelle
Summary
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 25.0), appendix (RPKM 19.5) and 25 other tissues See more
Orthologs
Try the new Gene page
Try the new Transcripts and proteins table
See IRAK1 in Genome Data Viewer
Location:
Xq28
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154010507..154019902, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152284194..152293583, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153275958..153285353, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene host cell factor C1 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:153234675-153234853 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30045 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153235869-153236718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21077 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21079 Neighboring gene HCFC1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30047 Neighboring gene transmembrane protein 187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30048 Neighboring gene CRISPRi-validated cis-regulatory element chrX.2695 Neighboring gene microRNA 3202-1 Neighboring gene microRNA 3202-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153265676-153266176 Neighboring gene NFE2L2 motif-containing MPRA enhancer 190/191 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153277410-153278394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153278395-153279378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21080 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21081 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153285318-153286287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30052 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153297889-153298431 Neighboring gene microRNA 718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153298432-153298975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153298976-153299518 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chrX:153301355-153301920 Neighboring gene methyl-CpG binding protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153306499-153306999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21083 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:153362776-153363014 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21085

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
EBI GWAS Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with IRAK1 promoter to downregulate IRAK1 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity TAS
Traceable Author Statement
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
NOT enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables signaling adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 
involved_in MyD88-dependent toll-like receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in NLRP3 inflammasome complex assembly NAS
Non-traceable Author Statement
more info
PubMed 
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical NF-kappaB signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 
involved_in interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in interleukin-33-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction TAS
Traceable Author Statement
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of MAP kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 2 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in toll-like receptor 2 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in toll-like receptor 9 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
involved_in toll-like receptor signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in type I interferon-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IC
Inferred by Curator
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
part_of serine/threonine protein kinase complex NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
interleukin-1 receptor-associated kinase 1
Names
Pelle homolog
NP_001020413.1
NP_001020414.1
NP_001397630.1
NP_001560.2
XP_047298053.1
XP_047298054.1
XP_054183009.1
XP_054183010.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008387.1 RefSeqGene

    Range
    4990..14385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025242.2NP_001020413.1  interleukin-1 receptor-associated kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001020413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AF346607, BC014963, BC054000, L76191, U52112
    Consensus CDS
    CCDS35444.1
    UniProtKB/TrEMBL
    A0ACI8TDD5
    Related
    ENSP00000377291.2, ENST00000393687.6
    Conserved Domains (3) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    pfam07714
    Location:217513
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:218513
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001025243.2NP_001020414.1  interleukin-1 receptor-associated kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_001020414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon, as compared to variant 1. The encoded isoform 3 thus lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC014963, BC054000, BE276817, L76191, U52112
    Consensus CDS
    CCDS35443.1
    UniProtKB/TrEMBL
    A0ACI8U9K5
    Related
    ENSP00000358991.2, ENST00000369974.6
    Conserved Domains (2) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:218434
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001410701.1NP_001397630.1  interleukin-1 receptor-associated kinase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    U52112
    Consensus CDS
    CCDS94700.1
    UniProtKB/TrEMBL
    A0ACI8U9J3, D3YTB5
    Related
    ENSP00000392662.2, ENST00000429936.6
  4. NM_001569.4NP_001560.2  interleukin-1 receptor-associated kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001560.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC014963, BC054000, BE276817, L76191, U52112
    Consensus CDS
    CCDS14740.1
    UniProtKB/Swiss-Prot
    D3DWW3, D3DWW4, P51617, Q7Z5V4, Q96C06, Q96RL2
    UniProtKB/TrEMBL
    A0ACI8TDR2
    Related
    ENSP00000358997.3, ENST00000369980.8
    Conserved Domains (3) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    pfam00069
    Location:212514
    Pkinase; Protein kinase domain
    cl21453
    Location:218521
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154010507..154019902 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047442098.1XP_047298054.1  interleukin-1 receptor-associated kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0ACI8TDD5
  2. XM_047442097.1XP_047298053.1  interleukin-1 receptor-associated kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0ACI8TDR2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152284194..152293583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327035.1XP_054183010.1  interleukin-1 receptor-associated kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0ACI8TDD5
  2. XM_054327034.1XP_054183009.1  interleukin-1 receptor-associated kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0ACI8TDR2