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IRAK1 interleukin 1 receptor associated kinase 1 [ Homo sapiens (human) ]

Gene ID: 3654, updated on 24-Nov-2020

Summary

Official Symbol
IRAK1provided by HGNC
Official Full Name
interleukin 1 receptor associated kinase 1provided by HGNC
Primary source
HGNC:HGNC:6112
See related
Ensembl:ENSG00000184216 MIM:300283
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRAK; pelle
Summary
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 25.0), appendix (RPKM 19.5) and 25 other tissues See more
Orthologs

Genomic context

See IRAK1 in Genome Data Viewer
Location:
Xq28
Exon count:
13
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (154010507..154019984, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153275957..153285342, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chrX.2695 Neighboring gene NFE2L2 motif-containing MPRA enhancer 190/191 Neighboring gene microRNA 718 Neighboring gene methyl-CpG binding protein 2 Neighboring gene opsin locus control region Neighboring gene opsin 1, long wave sensitive

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat specifically associates with IRAK1 promoter to downregulate IRAK1 expression in T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
NF-kappaB-inducing kinase activity TAS
Traceable Author Statement
more info
PubMed 
heat shock protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
JNK cascade TAS
Traceable Author Statement
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
activation of NF-kappaB-inducing kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
aging IEA
Inferred from Electronic Annotation
more info
 
cellular response to heat IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-1-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipopolysaccharide-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of leukocyte adhesion to vascular endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of type I interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation TAS
Traceable Author Statement
more info
PubMed 
regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to interleukin-1 IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
toll-like receptor 2 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor 2 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
type I interferon signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interleukin-1 receptor-associated kinase 1
Names
IRAK-1
Pelle homolog
NP_001020413.1
NP_001020414.1
NP_001560.2
XP_005274725.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008387.1 RefSeqGene

    Range
    4990..14385
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001025242.2NP_001020413.1  interleukin-1 receptor-associated kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001020413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The encoded isoform 2 thus lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AF346607, BC014963, BC054000, L76191, U52112
    Consensus CDS
    CCDS35444.1
    UniProtKB/Swiss-Prot
    P51617
    Related
    ENSP00000377291.2, ENST00000393687.6
    Conserved Domains (3) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    pfam07714
    Location:217513
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:218513
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001025243.2NP_001020414.1  interleukin-1 receptor-associated kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_001020414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon, as compared to variant 1. The encoded isoform 3 thus lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    BC014963, BC054000, BE276817, L76191, U52112
    Consensus CDS
    CCDS35443.1
    UniProtKB/Swiss-Prot
    P51617
    Related
    ENSP00000358991.2, ENST00000369974.6
    Conserved Domains (2) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:218434
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001569.4NP_001560.2  interleukin-1 receptor-associated kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001560.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC014963, BC054000, BE276817, L76191, U52112
    Consensus CDS
    CCDS14740.1
    UniProtKB/Swiss-Prot
    P51617
    Related
    ENSP00000358997.3, ENST00000369980.8
    Conserved Domains (3) summary
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    pfam00069
    Location:212514
    Pkinase; Protein kinase domain
    cl21453
    Location:218521
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    154010507..154019984 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274668.4XP_005274725.1  interleukin-1 receptor-associated kinase 1 isoform X1

    UniProtKB/TrEMBL
    D3YTB5
    Related
    ENSP00000392662.2, ENST00000429936.6
    Conserved Domains (3) summary
    cd08794
    Location:17126
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    pfam07714
    Location:243539
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:244539
    PKc_like; Protein Kinases, catalytic domain
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