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Irak1 interleukin-1 receptor-associated kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 16179, updated on 12-May-2024

Summary

Official Symbol
Irak1provided by MGI
Official Full Name
interleukin-1 receptor-associated kinase 1provided by MGI
Primary source
MGI:MGI:107420
See related
Ensembl:ENSMUSG00000031392 AllianceGenome:MGI:107420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IRAK; Plpk; mPLK; IRAK-1; IRAK1b; Il1rak; IRAK1-S
Summary
Enables interleukin-1 receptor binding activity and protein kinase activity. Involved in negative regulation of cholesterol efflux; negative regulation of transcription, DNA-templated; and positive regulation of JUN kinase activity. Acts upstream of or within several processes, including interleukin-1-mediated signaling pathway; response to molecule of bacterial origin; and toll-like receptor signaling pathway. Located in lipid droplet and membrane. Part of protein-containing complex. Is expressed in several structures, including liver; skeletal muscle; and urinary system. Human ortholog(s) of this gene implicated in ankylosing spondylitis; diffuse scleroderma; psoriatic arthritis; and squamous cell carcinoma. Orthologous to human IRAK1 (interleukin 1 receptor associated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 73.0), ovary adult (RPKM 47.6) and 27 other tissues See more
Orthologs
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Genomic context

See Irak1 in Genome Data Viewer
Location:
X A7.3; X 37.61 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73057520..73067527, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74013914..74023921, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene host cell factor C1 Neighboring gene STARR-seq mESC enhancer starr_47362 Neighboring gene STARR-seq mESC enhancer starr_47363 Neighboring gene STARR-seq mESC enhancer starr_47364 Neighboring gene predicted gene 8545 Neighboring gene microRNA 5132 Neighboring gene microRNA 718 Neighboring gene methyl CpG binding protein 2 Neighboring gene green (M) opsin gene upstream regulatory region Neighboring gene opsin 1 (cone pigments), medium-wave-sensitive (color blindness, deutan)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables interleukin-1 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in Toll signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in innate immune response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in interleukin-33-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to vascular endothelial cell ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to peptidoglycan IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 2 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within toll-like receptor 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in toll-like receptor 2 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor 4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
interleukin-1 receptor-associated kinase 1
Names
interleukin-1 receptor-associated kinase-1b
pelle-like protein kinase
NP_001171444.1
NP_001171445.1
NP_001171446.1
NP_001171447.1
NP_032389.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177973.1NP_001171444.1  interleukin-1 receptor-associated kinase 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AK143694, AL672002
    Consensus CDS
    CCDS53105.1
    UniProtKB/TrEMBL
    B1AUW6, Q99J34
    Related
    ENSMUSP00000033769.9, ENSMUST00000033769.15
    Conserved Domains (3) summary
    smart00221
    Location:219514
    STYKc; Protein kinase; unclassified specificity
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:219514
    PKc_like; Protein Kinases, catalytic domain
  2. NM_001177974.1NP_001171445.1  interleukin-1 receptor-associated kinase 1 isoform 4

    See identical proteins and their annotated locations for NP_001171445.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).
    Source sequence(s)
    AL672002, BP760087, U56773
    Consensus CDS
    CCDS30219.2
    UniProtKB/Swiss-Prot
    B1AUW4, Q62406, Q6Y3Z5, Q6Y3Z6
    UniProtKB/TrEMBL
    B1AUW9, Q540G0
    Related
    ENSMUSP00000064448.6, ENSMUST00000068286.12
    Conserved Domains (3) summary
    smart00221
    Location:218518
    STYKc; Protein kinase; unclassified specificity
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:218521
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001177975.1NP_001171446.1  interleukin-1 receptor-associated kinase 1 isoform 3

    See identical proteins and their annotated locations for NP_001171446.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AK143694, AL672002, BY729815
    Consensus CDS
    CCDS53104.1
    UniProtKB/TrEMBL
    B1AUW9, Q8BR10
    Related
    ENSMUSP00000109994.4, ENSMUST00000114354.10
    Conserved Domains (3) summary
    smart00221
    Location:219519
    STYKc; Protein kinase; unclassified specificity
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:219522
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001177976.1NP_001171447.1  interleukin-1 receptor-associated kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_001171447.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL672002, BP760087, U56773
    Consensus CDS
    CCDS53103.1
    UniProtKB/TrEMBL
    B1AUW9
    Related
    ENSMUSP00000110000.4, ENSMUST00000114360.10
    Conserved Domains (3) summary
    smart00221
    Location:218518
    STYKc; Protein kinase; unclassified specificity
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:218521
    PKc_like; Protein Kinases, catalytic domain
  5. NM_008363.2NP_032389.2  interleukin-1 receptor-associated kinase 1 isoform 4

    See identical proteins and their annotated locations for NP_032389.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1. Variants 4 and 5 encode the same protein (isoform 4).
    Source sequence(s)
    AF103876, AL672002
    Consensus CDS
    CCDS30219.2
    UniProtKB/Swiss-Prot
    B1AUW4, Q62406, Q6Y3Z5, Q6Y3Z6
    UniProtKB/TrEMBL
    B1AUW9, Q540G0
    Related
    ENSMUSP00000109992.2, ENSMUST00000114352.8
    Conserved Domains (3) summary
    smart00221
    Location:218518
    STYKc; Protein kinase; unclassified specificity
    cd08794
    Location:17100
    Death_IRAK1; Death domain of Interleukin 1 Receptor Associated Kinase-1
    cl21453
    Location:218521
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73057520..73067527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)