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ATP6V0B ATPase H+ transporting V0 subunit b [ Homo sapiens (human) ]

Gene ID: 533, updated on 13-Mar-2020

Summary

Official Symbol
ATP6V0Bprovided by HGNC
Official Full Name
ATPase H+ transporting V0 subunit bprovided by HGNC
Primary source
HGNC:HGNC:861
See related
Ensembl:ENSG00000117410 MIM:603717
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATP6F; HATPL; VMA16
Summary
This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 52.4), kidney (RPKM 31.0) and 25 other tissues See more
Orthologs

Genomic context

See ATP6V0B in Genome Data Viewer
Location:
1p34.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (43974960..43978295)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (44440118..44443972)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929609 Neighboring gene importin 13 Neighboring gene diphthamide biosynthesis 2 Neighboring gene beta-1,4-galactosyltransferase 2 Neighboring gene Sharpr-MPRA regulatory region 11322 Neighboring gene coiled-coil domain containing 24

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b (ATP6V0B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
ion transmembrane transport TAS
Traceable Author Statement
more info
 
phagosome acidification TAS
Traceable Author Statement
more info
 
proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of macroautophagy NAS
Non-traceable Author Statement
more info
PubMed 
transferrin transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
 
vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
V-type proton ATPase 21 kDa proteolipid subunit
Names
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
ATPase, H+ transporting, lysosomal, 21-KD, V0 subunit C-prime, prime
ATPase, H+ transporting, lysosomal, subunit F
H(+)-transporting two-sector ATPase, subunit F
V-ATPase 21 kDa proteolipid subunit
V-ATPase subunit c''
vacuolar ATP synthase 21 kDa proteolipid subunit
vacuolar proton pump 21 kDa proteolipid subunit
NP_001034546.1
NP_001281262.1
NP_004038.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039457.3NP_001034546.1  V-type proton ATPase 21 kDa proteolipid subunit isoform 2

    See identical proteins and their annotated locations for NP_001034546.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI439545, BG475609, D89052
    Consensus CDS
    CCDS41315.1
    UniProtKB/Swiss-Prot
    Q99437
    Related
    ENSP00000236067.4, ENST00000236067.8
    Conserved Domains (1) summary
    pfam00137
    Location:91149
    ATP-synt_C; ATP synthase subunit C
  2. NM_001294333.2NP_001281262.1  V-type proton ATPase 21 kDa proteolipid subunit isoform 3

    See identical proteins and their annotated locations for NP_001281262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate segment in the 3' region, which results in a frameshift, compared to variant 1. The encoded isoform (3) has a longer and distinct C-terminus, compared to variant 1.
    Source sequence(s)
    AL357079
    Consensus CDS
    CCDS72772.1
    UniProtKB/TrEMBL
    E9PNL3
    Related
    ENSP00000434729.1, ENST00000532642.5
    Conserved Domains (2) summary
    PRK08344
    Location:48199
    PRK08344; V-type ATP synthase subunit K; Validated
    pfam00137
    Location:136196
    ATP-synt_C; ATP synthase subunit C
  3. NM_004047.5NP_004038.1  V-type proton ATPase 21 kDa proteolipid subunit isoform 1

    See identical proteins and their annotated locations for NP_004038.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AI439545, D89052
    Consensus CDS
    CCDS505.1
    UniProtKB/Swiss-Prot
    Q99437
    Related
    ENSP00000431605.1, ENST00000472174.7
    Conserved Domains (1) summary
    pfam00137
    Location:138196
    ATP-synt_C; ATP synthase subunit C

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    43974960..43978295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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