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Atp6v0b ATPase, H+ transporting, lysosomal V0 subunit B [ Mus musculus (house mouse) ]

Gene ID: 114143, updated on 19-Jun-2024

Summary

Official Symbol
Atp6v0bprovided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit Bprovided by MGI
Primary source
MGI:MGI:1890510
See related
Ensembl:ENSMUSG00000033379 AllianceGenome:MGI:1890510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp6f; VMA16; 2310024H13Rik
Summary
Predicted to enable P-type proton-exporting transporter activity. Predicted to act upstream of or within proton transmembrane transport. Located in endosome. Is integral component of membrane. Is expressed in several structures, including genitourinary system; liver; nervous system; nose; and spleen. Orthologous to human ATP6V0B (ATPase H+ transporting V0 subunit b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 210.8), adrenal adult (RPKM 164.8) and 28 other tissues See more
Orthologs
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Genomic context

See Atp6v0b in Genome Data Viewer
Location:
4 D1; 4 53.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (117741523..117744548, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117884330..117887333, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 6 (neurotransmitter transporter, glycine), member 9 Neighboring gene coiled-coil domain containing 24 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 Neighboring gene predicted gene, 40233 Neighboring gene predicted gene 12841 Neighboring gene STARR-positive B cell enhancer ABC_E4652 Neighboring gene DPH2 homolog Neighboring gene importin 13 Neighboring gene STARR-positive B cell enhancer ABC_E10251

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables P-type proton-exporting transporter activity ISA
Inferred from Sequence Alignment
more info
PubMed 
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proton transmembrane transport ISA
Inferred from Sequence Alignment
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting V-type ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proton-transporting V-type ATPase, V0 domain ISA
Inferred from Sequence Alignment
more info
PubMed 
part_of proton-transporting two-sector ATPase complex, proton-transporting domain IEA
Inferred from Electronic Annotation
more info
 
part_of vacuolar proton-transporting V-type ATPase complex ISA
Inferred from Sequence Alignment
more info
PubMed 

General protein information

Preferred Names
V-type proton ATPase 21 kDa proteolipid subunit c''
Names
23 kDa subunit of V-ATPase
ATPase, H+ transporting, V0 subunit B
ATPase, H+ transporting, lysosomal (vacuolar proton pump)
ATPase, H+ transporting, lysosomal 21kDa, V0 subunit B
V-ATPase 21 kDa proteolipid subunit
V-ATPase 21 kDa proteolipid subunit c''
V-type proton ATPase 21 kDa proteolipid subunit
lysosomal 21kDa
vacuolar proton pump 21 kDa proteolipid subunit
vacuolar proton pump 21 kDa proteolipid subunit c''
NP_001406271.1
NP_291095.1
XP_030108954.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419342.1NP_001406271.1  V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL627128
    UniProtKB/TrEMBL
    A0A0A0MQJ5
    Related
    ENSMUSP00000119988.3, ENSMUST00000150204.8
  2. NM_033617.4NP_291095.1  V-type proton ATPase 21 kDa proteolipid subunit c'' isoform 1

    See identical proteins and their annotated locations for NP_291095.1

    Status: VALIDATED

    Source sequence(s)
    AL627128
    Consensus CDS
    CCDS18540.1
    UniProtKB/Swiss-Prot
    Q91V37
    UniProtKB/TrEMBL
    Q3U889, Q8JZR5
    Related
    ENSMUSP00000047682.8, ENSMUST00000036380.14
    Conserved Domains (2) summary
    cd18177
    Location:49111
    ATP-synt_Vo_c_ATP6F_rpt1; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins
    cd18178
    Location:133197
    ATP-synt_Vo_c_ATP6F_rpt2; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins

RNA

  1. NR_185061.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627128
  2. NR_185062.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL627128

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    117741523..117744548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253094.2XP_030108954.1  V-type proton ATPase 21 kDa proteolipid subunit c'' isoform X1

    UniProtKB/TrEMBL
    A0A0A0MQJ5
    Conserved Domains (2) summary
    cd18177
    Location:264
    ATP-synt_Vo_c_ATP6F_rpt1; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins
    cd18178
    Location:86150
    ATP-synt_Vo_c_ATP6F_rpt2; V-type proton ATPase 21 kDa proteolipid subunit (ATP6F/ATP6V0B) and similar proteins