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PLA2G2A phospholipase A2 group IIA [ Homo sapiens (human) ]

Gene ID: 5320, updated on 13-Jan-2019

Summary

Official Symbol
PLA2G2Aprovided by HGNC
Official Full Name
phospholipase A2 group IIAprovided by HGNC
Primary source
HGNC:HGNC:9031
See related
Ensembl:ENSG00000188257 MIM:172411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MOM1; PLA2; PLA2B; PLA2L; PLA2S; PLAS1; sPLA2
Summary
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]
Expression
Biased expression in colon (RPKM 828.3), small intestine (RPKM 526.6) and 7 other tissues See more
Orthologs

Genomic context

See PLA2G2A in Genome Data Viewer
Location:
1p36.13
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (19975431..19980439, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (20301924..20306932, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group IIE Neighboring gene RNA, 7SL, cytoplasmic 304, pseudogene Neighboring gene prenylcysteine oxidase 1 pseudogene Neighboring gene phospholipase A2 group V Neighboring gene phospholipase A2 group IID

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipase A2 activity TAS
Traceable Author Statement
more info
PubMed 
phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase A2 activity IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase A2 activity TAS
Traceable Author Statement
more info
 
phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-positive bacterium TAS
Traceable Author Statement
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle remodeling TAS
Traceable Author Statement
more info
PubMed 
phosphatidic acid biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylglycerol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylinositol acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phosphatidylserine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of macrophage derived foam cell differentiation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
secretory granule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phospholipase A2, membrane associated
Names
GIIC sPLA2
NPS-PLA2
group IIA phospholipase A2
non-pancreatic secretory phospholipase A2
phosphatidylcholine 2-acylhydrolase 2A
phospholipase A2, group IIA (platelets, synovial fluid)
NP_000291.1
NP_001155199.1
NP_001155200.1
NP_001155201.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012928.1 RefSeqGene

    Range
    5001..10009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000300.3NP_000291.1  phospholipase A2, membrane associated precursor

    See identical proteins and their annotated locations for NP_000291.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant and longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC005919, BU626291, BX641714
    Consensus CDS
    CCDS201.1
    UniProtKB/Swiss-Prot
    P14555
    UniProtKB/TrEMBL
    A0A024RA96
    Related
    ENSP00000364252.3, ENST00000375111.7
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  2. NM_001161727.1NP_001155199.1  phospholipase A2, membrane associated precursor

    See identical proteins and their annotated locations for NP_001155199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at one of the 5' non-coding exons compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BU626291, BX641714, CB132375
    Consensus CDS
    CCDS201.1
    UniProtKB/Swiss-Prot
    P14555
    UniProtKB/TrEMBL
    A0A024RA96
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  3. NM_001161728.1NP_001155200.1  phospholipase A2, membrane associated precursor

    See identical proteins and their annotated locations for NP_001155200.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing one of the 5' non-coding exons compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC005919, BU626291, BX641714
    Consensus CDS
    CCDS201.1
    UniProtKB/Swiss-Prot
    P14555
    UniProtKB/TrEMBL
    A0A024RA96
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...
  4. NM_001161729.1NP_001155201.1  phospholipase A2, membrane associated precursor

    See identical proteins and their annotated locations for NP_001155201.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate acceptor splice site in the 5' non-coding region compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC005919, BM708748, BU626291
    Consensus CDS
    CCDS201.1
    UniProtKB/Swiss-Prot
    P14555
    UniProtKB/TrEMBL
    A0A024RA96
    Related
    ENSP00000383364.3, ENST00000400520.7
    Conserved Domains (1) summary
    cd00125
    Location:21137
    PLA2c; PLA2c: Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    19975431..19980439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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