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Pla2g2a phospholipase A2, group IIA (platelets, synovial fluid) [ Mus musculus (house mouse) ]

Gene ID: 18780, updated on 12-May-2024

Summary

Official Symbol
Pla2g2aprovided by MGI
Official Full Name
phospholipase A2, group IIA (platelets, synovial fluid)provided by MGI
Primary source
MGI:MGI:104642
See related
Ensembl:ENSMUSG00000058908 AllianceGenome:MGI:104642
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EF; Mom1; Pla2; sPLA2; sPla2-IIA
Summary
Proteins belonging to the phospholipase A2 (PLA2) family hydrolyze phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in other strains. [provided by RefSeq, Jul 2008]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Expression
Restricted expression toward large intestine adult (RPKM 41.5) See more
Orthologs
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Genomic context

Location:
4 D3; 4 70.57 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138559168..138562500)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138831857..138835189)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32871 Neighboring gene phospholipase A2, group IID Neighboring gene STARR-seq mESC enhancer starr_11818 Neighboring gene phospholipase A2, group V Neighboring gene predicted gene, 25280 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138412463-138412764 Neighboring gene STARR-positive B cell enhancer mm9_chr4:138422386-138422686 Neighboring gene predicted gene, 32930 Neighboring gene predicted gene 13030

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Spontaneous (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phosphatidic acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylethanolamine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neutrophil activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipase A2, membrane associated
Names
GIIC sPLA2
enhancing factor
group IIA phospholipase A2
modifier of Min1
non-pancreatic secreted type II phospholipase A2
phosphatidylcholine 2-acylhydrolase 2A
secretory group II phospholipase A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082531.1NP_001076000.1  phospholipase A2, membrane associated precursor

    See identical proteins and their annotated locations for NP_001076000.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, coding) contains a gap in the coding region to represent the functional allele that is not present in the the strain of the reference genome, C57BL/6J.
    Source sequence(s)
    BC045156
    UniProtKB/Swiss-Prot
    P31482, Q60871
    UniProtKB/TrEMBL
    V5TDK8, V5TDL3
    Conserved Domains (1) summary
    smart00085
    Location:22139
    PA2c; Phospholipase A2

RNA

  1. NR_002926.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, non-coding) represents the non-functional allele that is present in several strains, including the strain of the reference genome, C57BL/6J. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, coding, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK131857, CB933893
    Related
    ENSMUST00000135748.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    138559168..138562500
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_011108.1: Suppressed sequence

    Description
    NM_011108.1: This RefSeq was permanently suppressed because it contains a frame-shift, which results in premature translation termination, thus rendering the transcript susceptible to nonsense-mediated mRNA decay (NMD).