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PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [ Homo sapiens (human) ]

Gene ID: 5303, updated on 5-Aug-2018

Summary

Official Symbol
PIN4provided by HGNC
Official Full Name
peptidylprolyl cis/trans isomerase, NIMA-interacting 4provided by HGNC
Primary source
HGNC:HGNC:8992
See related
Ensembl:ENSG00000102309 MIM:300252; Vega:OTTHUMG00000021811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPVH; PAR14; PAR17
Summary
This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in liver (RPKM 5.5), kidney (RPKM 4.8) and 25 other tissues See more
Orthologs

Genomic context

See PIN4 in Genome Data Viewer
Location:
Xq13.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (72181676..72263964)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (71401526..71483814)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene NHS like 2 Neighboring gene TPT1-like protein Neighboring gene retrotransposon Gag like 5 Neighboring gene RNA, 7SL, cytoplasmic 388, pseudogene Neighboring gene ERCC excision repair 6 like, spindle assembly checkpoint helicase Neighboring gene uncharacterized LOC105373250 Neighboring gene ribosomal protein S4 X-linked Neighboring gene Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138486

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
Names
PPIase PIN4
eukaryotic parvulin homolog
hEPVH
hPar14
hPar17
parvulin
parvulin-14
parvulin-17
peptidyl-prolyl cis-trans isomerase Pin4
peptidyl-prolyl cis/trans isomerase EPVH
protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
rotamase PIN4
NP_001164218.1
NP_006214.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016328.1 RefSeqGene

    Range
    5001..21669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170747.1NP_001164218.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK127605, AU098526, AV709926
    Consensus CDS
    CCDS55447.1
    UniProtKB/Swiss-Prot
    Q9Y237
    Related
    ENSP00000409154.2, ENST00000423432.6
    Conserved Domains (1) summary
    cl08278
    Location:55101
    Rotamase_2; PPIC-type PPIASE domain
  2. NM_006223.3NP_006214.2  peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AU098526, AV709926, BC111394, BC112281, BE504461, BU952002
    Consensus CDS
    CCDS14417.1
    UniProtKB/Swiss-Prot
    Q9Y237
    Related
    ENSP00000362773.2, OTTHUMP00000023526, ENST00000373669.6, OTTHUMT00000057175
    Conserved Domains (1) summary
    cl08278
    Location:55156
    Rotamase_2; PPIC-type PPIASE domain

RNA

  1. NR_033187.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AU098526, AV709926, BC111394, BC112281, BE504461, BU952002

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    72181676..72263964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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