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PIM1 Pim-1 proto-oncogene, serine/threonine kinase [ Homo sapiens (human) ]

Gene ID: 5292, updated on 9-Oct-2021

Summary

Official Symbol
PIM1provided by HGNC
Official Full Name
Pim-1 proto-oncogene, serine/threonine kinaseprovided by HGNC
Primary source
HGNC:HGNC:8986
See related
Ensembl:ENSG00000137193 MIM:164960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIM
Summary
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
Expression
Broad expression in bone marrow (RPKM 89.3), esophagus (RPKM 60.8) and 21 other tissues See more
Orthologs
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Genomic context

See PIM1 in Genome Data Viewer
Location:
6p21.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (37170152..37175428)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (37137928..37143204)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 2 Neighboring gene CRISPRi-validated cis-regulatory element chr6.2479 Neighboring gene transmembrane protein 217 Neighboring gene TBC1 domain family member 22B Neighboring gene Sharpr-MPRA regulatory region 3623

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of pim-1 oncogene (PIM1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosomal small subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular detoxification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardioblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of hematopoietic stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vitamin D receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase pim-1
Names
Oncogene PIM1
pim-1 oncogene (proviral integration site 1)
proto-oncogene serine/threonine-protein kinase pim-1
NP_001230115.1
NP_002639.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029601.1 RefSeqGene

    Range
    5007..10283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001243186.2NP_001230115.1  serine/threonine-protein kinase pim-1 isoform 1

    See identical proteins and their annotated locations for NP_001230115.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternate in-frame, translation initiation codons. This RefSeq represents the longer isoform (1, also known as Pim-1L) derived from the use of an upstream non-AUG (CUG) start codon (at nt 158-160). Pim-1L has been shown to localize primarily on the plasma membrane, and to confer resistance to chemotherapeutic drugs in prostate cancer cells (PMID:16186805).
    Source sequence(s)
    BC020224, DA481890, DA489942, M24779
    UniProtKB/Swiss-Prot
    P11309
    Conserved Domains (1) summary
    cd14100
    Location:128381
    STKc_PIM1; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1
  2. NM_002648.4NP_002639.1  serine/threonine-protein kinase pim-1 isoform 2

    See identical proteins and their annotated locations for NP_002639.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternate in-frame, translation initiation codons. This RefSeq represents the shorter isoform (2, also known as Pim-1S) derived from the use of a downstream AUG (at nt 431-433). Pim-1S has been shown to localize predominantly in the nucleus (PMID:16186805).
    Source sequence(s)
    AL353579, BC020224, DA434260, DA481890
    Consensus CDS
    CCDS4830.1
    UniProtKB/Swiss-Prot
    P11309
    UniProtKB/TrEMBL
    A0A024RD25
    Related
    ENSP00000362608.5, ENST00000373509.6
    Conserved Domains (1) summary
    cd14100
    Location:37290
    STKc_PIM1; Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    37170152..37175428
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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