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Pim1 proviral integration site 1 [ Mus musculus (house mouse) ]

Gene ID: 18712, updated on 17-Jun-2024

Summary

Official Symbol
Pim1provided by MGI
Official Full Name
proviral integration site 1provided by MGI
Primary source
MGI:MGI:97584
See related
Ensembl:ENSMUSG00000024014 AllianceGenome:MGI:97584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pim-1
Summary
Enables ATP binding activity; manganese ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of brown fat cell differentiation; protein stabilization; and regulation of hematopoietic stem cell proliferation. Predicted to be located in cytosol; nucleolus; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including gonad; primitive streak; and spleen. Orthologous to human PIM1 (Pim-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 59.9), duodenum adult (RPKM 47.0) and 24 other tissues See more
Orthologs
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Genomic context

See Pim1 in Genome Data Viewer
Location:
17 A3.3; 17 15.38 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29709759..29715085)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29490785..29496111)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5586 Neighboring gene STARR-positive B cell enhancer ABC_E7508 Neighboring gene STARR-positive B cell enhancer ABC_E10944 Neighboring gene STARR-seq mESC enhancer starr_42277 Neighboring gene FYVE, RhoGEF and PH domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_42278 Neighboring gene STARR-positive B cell enhancer ABC_E2478 Neighboring gene STARR-positive B cell enhancer ABC_E8664 Neighboring gene VISTA enhancer mm81 Neighboring gene STARR-positive B cell enhancer mm9_chr17:29574287-29574588 Neighboring gene predicted gene, 36486 Neighboring gene STARR-seq mESC enhancer starr_42287 Neighboring gene predicted gene, 36199 Neighboring gene VISTA enhancer mm755 Neighboring gene predicted gene, 26885 Neighboring gene STARR-positive B cell enhancer ABC_E2479 Neighboring gene STARR-positive B cell enhancer ABC_E5587 Neighboring gene STARR-positive B cell enhancer ABC_E8946 Neighboring gene STARR-positive B cell enhancer ABC_E9949 Neighboring gene transmembrane 217B Neighboring gene transmembrane protein 217 Neighboring gene STARR-seq mESC enhancer starr_42293 Neighboring gene TBC1 domain family, member 22B Neighboring gene TBC1 domain family, member 22B, opposite strand Neighboring gene microRNA 7667

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables ribosomal small subunit binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular detoxification ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardioblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in vitamin D receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase pim-1
Names
proto-oncogene serine/threonine-protein kinase pim-1
NP_001351842.1
NP_032868.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364913.1NP_001351842.1  serine/threonine-protein kinase pim-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163629
    Consensus CDS
    CCDS89050.1
    UniProtKB/TrEMBL
    A0A3Q4EGX3
    Related
    ENSMUSP00000157217.2, ENSMUST00000234665.2
    Conserved Domains (1) summary
    cl21453
    Location:156
    PKc_like; Protein Kinases, catalytic domain
  2. NM_008842.4NP_032868.2  serine/threonine-protein kinase pim-1 isoform 1

    See identical proteins and their annotated locations for NP_032868.2

    Status: VALIDATED

    Source sequence(s)
    AA881360, AC163629, AK158445, BC053019
    Consensus CDS
    CCDS79520.1
    UniProtKB/Swiss-Prot
    F6XDQ5, P06803, Q8CFN8
    Related
    ENSMUSP00000024811.8, ENSMUST00000024811.9
    Conserved Domains (1) summary
    cl21453
    Location:37290
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29709759..29715085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)