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PIGF phosphatidylinositol glycan anchor biosynthesis class F [ Homo sapiens (human) ]

Gene ID: 5281, updated on 13-Feb-2019

Summary

Official Symbol
PIGFprovided by HGNC
Official Full Name
phosphatidylinositol glycan anchor biosynthesis class Fprovided by HGNC
Primary source
HGNC:HGNC:8962
See related
Ensembl:ENSG00000151665 MIM:600153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Annotation information
Note: PGF (Gene ID: 5228) and PIGF (Gene ID: 5281) share the PIGF symbol/alias in common. PIGF is a widely used alternative gene symbol for placental growth factor (PGF), which can be confused with the official symbol for phosphatidylinositol glycan anchor biosynthesis class F (PIGF). [06 Jul 2018]
Expression
Ubiquitous expression in fat (RPKM 42.1), heart (RPKM 35.0) and 25 other tissues See more
Orthologs

Genomic context

See PIGF in Genome Data Viewer
Location:
2p21
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (46581274..46617112, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (46808413..46844251, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V1 subunit E2 Neighboring gene ras homolog family member Q Neighboring gene uncharacterized LOC100506142 Neighboring gene CXXC repeat containing interactor of PDZ3 domain Neighboring gene uncharacterized LOC105374584

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of phosphatidylinositol glycan anchor biosynthesis, class F (PIGF) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC32646, MGC33136

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ethanolaminephosphotransferase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
GPI anchor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
preassembly of GPI anchor in ER membrane TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol-glycan biosynthesis class F protein
Names
GPI11 homolog
PIG-F
NP_002634.1
NP_775097.1
XP_005264426.1
XP_011531210.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002643.3NP_002634.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

    See identical proteins and their annotated locations for NP_002634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC018682, BC029408
    Consensus CDS
    CCDS1827.1
    UniProtKB/Swiss-Prot
    Q07326
    UniProtKB/TrEMBL
    Q6IB04
    Related
    ENSP00000281382.6, ENST00000281382.10
    Conserved Domains (1) summary
    pfam06699
    Location:21204
    PIG-F; GPI biosynthesis protein family Pig-F
  2. NM_173074.2NP_775097.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 2

    See identical proteins and their annotated locations for NP_775097.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC018682, BC029408
    Consensus CDS
    CCDS1828.1
    UniProtKB/Swiss-Prot
    Q07326
    Related
    ENSP00000302663.4, ENST00000306465.8
    Conserved Domains (1) summary
    pfam06699
    Location:21182
    PIG-F; GPI biosynthesis protein family Pig-F

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    46581274..46617112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011532908.3XP_011531210.1  phosphatidylinositol-glycan biosynthesis class F protein isoform X1

    Conserved Domains (1) summary
    pfam06699
    Location:21185
    PIG-F; GPI biosynthesis protein family Pig-F
  2. XM_005264369.3XP_005264426.1  phosphatidylinositol-glycan biosynthesis class F protein isoform X2

    See identical proteins and their annotated locations for XP_005264426.1

    Conserved Domains (1) summary
    pfam06699
    Location:21183
    PIG-F; GPI biosynthesis protein family Pig-F
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