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Pigf phosphatidylinositol glycan anchor biosynthesis, class F [ Mus musculus (house mouse) ]

Gene ID: 18701, updated on 8-Dec-2022

Summary

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Official Symbol
Pigfprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Fprovided by MGI
Primary source
MGI:MGI:99462
See related
Ensembl:ENSMUSG00000024145 AllianceGenome:MGI:99462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mannose-ethanolamine phosphotransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human PIGF (phosphatidylinositol glycan anchor biosynthesis class F). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 37.0), bladder adult (RPKM 17.1) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Pigf in Genome Data Viewer
Location:
17 E4; 17 56.9 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87304684..87332975, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (86997259..87025401, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene hapless 2-like Neighboring gene predicted gene, 50012 Neighboring gene ras homolog family member Q Neighboring gene cysteine-rich PDZ-binding protein Neighboring gene predicted gene, 30421 Neighboring gene predicted gene, 24648

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of the murine GPI anchor synthesis gene Pigf, a homologue of the human PIGF gene. Ohishi K, et al. Genomics, 1996 Jun 15. PMID 8786134
  2. Altered tumor vessel maturation and proliferation in placenta growth factor-producing tumors: potential relationship to post-therapy tumor angiogenesis and recurrence. Taylor AP, et al. Int J Cancer, 2003 Jun 10. PMID 12673673
  3. Structure and chromosomal localization of the GPI-anchor synthesis gene PIGF and its pseudogene psi PIGF. Ohishi K, et al. Genomics, 1995 Oct 10. PMID 8575782
  4. A mouse model for cystinuria type I. Peters T, et al. Hum Mol Genet, 2003 Sep 1. PMID 12923163
  5. Requirement of PIG-F and PIG-O for transferring phosphoethanolamine to the third mannose in glycosylphosphatidylinositol. Hong Y, et al. J Biol Chem, 2000 Jul 7. PMID 10781593

See all (33) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mannose-ethanolamine phosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol-glycan biosynthesis class F protein
Names
PIG-F
phosphatidylinositol glycan, class F
NP_032864.1
XP_036016296.1
XP_036016297.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411401.1 → NP_001398330.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492
    UniProtKB/Swiss-Prot
    O09101
    UniProtKB/TrEMBL
    A0A8C6GVZ1

  2. NM_001411402.1 → NP_001398331.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492
    UniProtKB/Swiss-Prot
    O09101
    UniProtKB/TrEMBL
    A0A8C6GVZ1

  3. NM_001411403.1 → NP_001398332.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492
    UniProtKB/Swiss-Prot
    O09101
    UniProtKB/TrEMBL
    A0A8C6GVZ1

  4. NM_001411404.1 → NP_001398333.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492
    UniProtKB/Swiss-Prot
    O09101
    UniProtKB/TrEMBL
    A0A8C6GVZ1

  5. NM_001411405.1 → NP_001398334.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  6. NM_001411406.1 → NP_001398335.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  7. NM_001411407.1 → NP_001398336.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  8. NM_001411408.1 → NP_001398337.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  9. NM_001411409.1 → NP_001398338.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  10. NM_001411410.1 → NP_001398339.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  11. NM_001411411.1 → NP_001398340.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  12. NM_001411412.1 → NP_001398341.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  13. NM_008838.2 → NP_032864.1  phosphatidylinositol-glycan biosynthesis class F protein isoform 1

    See identical proteins and their annotated locations for NP_032864.1

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492
    Consensus CDS
    CCDS29011.1
    UniProtKB/Swiss-Prot
    O09101
    UniProtKB/TrEMBL
    A0A8C6GVZ1
    Related
    ENSMUSP00000024957.7, ENSMUST00000024957.7
    Conserved Domains (1) summary
    pfam06699
    Location:22 → 204
    PIG-F; GPI biosynthesis protein family Pig-F

RNA

  1. NR_177246.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  2. NR_177247.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

  3. NR_177248.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC127695, AC154492

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    87304684..87332975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160404.1 → XP_036016297.1  phosphatidylinositol-glycan biosynthesis class F protein isoform X1

    Conserved Domains (1) summary
    pfam06699
    Location:22 → 204
    PIG-F; GPI biosynthesis protein family Pig-F

  2. XM_036160403.1 → XP_036016296.1  phosphatidylinositol-glycan biosynthesis class F protein isoform X1

    Conserved Domains (1) summary
    pfam06699
    Location:22 → 204
    PIG-F; GPI biosynthesis protein family Pig-F
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09101.1 GenPept UniProtKB/Swiss-Prot:O09101

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