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ATP5PF ATP synthase peripheral stalk subunit F6 [ Homo sapiens (human) ]

Gene ID: 522, updated on 4-Oct-2020

Summary

Official Symbol
ATP5PFprovided by HGNC
Official Full Name
ATP synthase peripheral stalk subunit F6provided by HGNC
Primary source
HGNC:HGNC:847
See related
Ensembl:ENSG00000154723 MIM:603152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F6; CF6; ATP5; ATPM; ATP5A; ATP5J
Summary
Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo complex has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the F6 subunit of the Fo complex. The F6 subunit is required for F1 and Fo interactions. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has 1 or more pseudogenes. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in heart (RPKM 71.0), kidney (RPKM 49.2) and 25 other tissues See more
Orthologs

Genomic context

See ATP5PF in Genome Data Viewer
Location:
21q21.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (25724500..25735653, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (27096791..27107965, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene junctional adhesion molecule 2 Neighboring gene RNA guanylyltransferase and 5'-phosphatase pseudogene 1 Neighboring gene ferredoxin 1 pseudogene 2 Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene LLPH pseudogene 2 Neighboring gene uncharacterized LOC105372757

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 (ATP5J) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
cristae formation TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ATP synthesis coupled proton transport TAS
Traceable Author Statement
more info
 
negative regulation of arachidonic acid secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of prostaglandin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
response to muscle activity IEA
Inferred from Electronic Annotation
more info
 
substantia nigra development HEP PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ATP synthase-coupling factor 6, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F6
ATP synthase, H+ transporting, mitochondrial Fo complex subunit F6
ATPase subunit F6
coupling factor 6
mitochondrial ATP synthase, coupling factor 6
mitochondrial ATP synthase, subunit F6
mitochondrial ATPase coupling factor 6
proliferation-inducing protein 36
NP_001003696.1
NP_001003697.1
NP_001003701.1
NP_001003703.1
NP_001307195.1
NP_001307196.1
NP_001676.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003696.2NP_001003696.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001003696.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
    Source sequence(s)
    AI085837, BC001178, BC066310, BU174560
    Consensus CDS
    CCDS13574.1
    UniProtKB/Swiss-Prot
    P18859
    UniProtKB/TrEMBL
    Q6IB54, Q6NZ59
    Related
    ENSP00000382959.3, ENST00000400087.7
    Conserved Domains (1) summary
    pfam05511
    Location:196
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  2. NM_001003697.2NP_001003697.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001003697.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
    Source sequence(s)
    AI085837, BC001178, BC066310, BG938438
    Consensus CDS
    CCDS13574.1
    UniProtKB/Swiss-Prot
    P18859
    UniProtKB/TrEMBL
    Q6IB54, Q6NZ59
    Related
    ENSP00000382962.3, ENST00000400090.7
    Conserved Domains (1) summary
    pfam05511
    Location:196
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  3. NM_001003701.2NP_001003701.1  ATP synthase-coupling factor 6, mitochondrial isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, compared to variant 1. The predicted isoform (b) is longer, and it contains a distinct N-terminus, compared to isoform a. The translation initiation site for this transcript is inferred.
    Source sequence(s)
    AI085837, BC001178, BC066310, BI093033
    Consensus CDS
    CCDS46637.1
    UniProtKB/Swiss-Prot
    P18859
    UniProtKB/TrEMBL
    Q6NZ59
    Related
    ENSP00000389649.2, ENST00000457143.6
    Conserved Domains (1) summary
    pfam05511
    Location:9104
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  4. NM_001003703.2NP_001003703.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001003703.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
    Source sequence(s)
    AI085837, BC001178, BC066310, BQ268216
    Consensus CDS
    CCDS13574.1
    UniProtKB/Swiss-Prot
    P18859
    UniProtKB/TrEMBL
    Q6IB54, Q6NZ59
    Related
    ENSP00000284971.3, ENST00000284971.7
    Conserved Domains (1) summary
    pfam05511
    Location:196
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  5. NM_001320266.2NP_001307195.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
    Source sequence(s)
    AA364611, AI085837, BQ268216, HY146471
    Consensus CDS
    CCDS13574.1
    UniProtKB/Swiss-Prot
    P18859
    UniProtKB/TrEMBL
    Q6IB54
    Related
    ENSP00000382966.1, ENST00000400094.5
    Conserved Domains (1) summary
    pfam05511
    Location:196
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  6. NM_001320267.2NP_001307196.1  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
    Source sequence(s)
    AI085837, BQ268216, CN260182, HY146471
    Consensus CDS
    CCDS13574.1
    UniProtKB/Swiss-Prot
    P18859
    UniProtKB/TrEMBL
    Q6IB54
    Conserved Domains (1) summary
    pfam05511
    Location:196
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  7. NM_001685.5NP_001676.2  ATP synthase-coupling factor 6, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_001676.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, 4, 6 and 7 encode the same isoform (a).
    Source sequence(s)
    AI085837, BC001178, BC066310
    Consensus CDS
    CCDS13574.1
    UniProtKB/Swiss-Prot
    P18859
    UniProtKB/TrEMBL
    Q6IB54, Q6NZ59
    Related
    ENSP00000382965.3, ENST00000400093.3
    Conserved Domains (1) summary
    pfam05511
    Location:196
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    25724500..25735653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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