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Atp5j ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F [ Mus musculus (house mouse) ]

Gene ID: 11957, updated on 31-Jan-2019

Summary

Official Symbol
Atp5jprovided by MGI
Official Full Name
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit Fprovided by MGI
Primary source
MGI:MGI:107777
See related
Ensembl:ENSMUSG00000022890
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CF6; Atp5pf
Summary
The protein encoded by this gene is a component of mitochondrial adenosine triphosphate synthase, which catalyzes the conversion of ATP from ADP. Mitochondrial adenosine triphosphate synthase consists of extrinsic and intrinsic membrane domains that are joined by a stalk. The protein encoded by this gene is a subunit of the stalk domain. A bi-directional promoter that drives expression of this gene has been has been identified. Pseudogenes of this gene are found on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in heart adult (RPKM 199.5), kidney adult (RPKM 107.4) and 28 other tissues See more
Orthologs

Genomic context

See Atp5j in Genome Data Viewer
Location:
16; 16 C3.3
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (84827871..84835625, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (84828116..84835819, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32202 Neighboring gene junction adhesion molecule 2 Neighboring gene predicted gene, 46557 Neighboring gene GA repeat binding protein, alpha Neighboring gene predicted gene 10791 Neighboring gene amyloid beta (A4) precursor protein Neighboring gene predicted gene, 41482

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to ATPase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
ATP synthesis coupled proton transport IEA
Inferred from Electronic Annotation
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of arachidonic acid secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of prostaglandin secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane HDA PubMed 
mitochondrial proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
 
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) ISO
Inferred from Sequence Orthology
more info
 
mitochondrion HDA PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ATP synthase-coupling factor 6, mitochondrial
Names
ATP synthase coupling factor VI
ATP synthase peripheral stalk subunit F6
ATPase subunit F6
NP_001289142.1
NP_001289143.1
NP_001289144.1
NP_001289145.1
NP_058035.1
XP_006522939.1
XP_006522940.1
XP_011244394.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302213.1NP_001289142.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001289142.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AA259963, AI326720, BE851144, BE995304
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    Related
    ENSMUSP00000109829.1, ENSMUST00000114191.7
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  2. NM_001302214.1NP_001289143.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001289143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AA259963, AC164162, AK078484
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  3. NM_001302215.1NP_001289144.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001289144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AA259963, AC164162, U77128, W75852
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    Related
    ENSMUSP00000109831.1, ENSMUST00000114193.7
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  4. NM_001302216.1NP_001289145.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001289145.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AA259963, BY079469, U77128
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  5. NM_001358499.1NP_001345428.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  6. NM_001358500.1NP_001345429.1  ATP synthase-coupling factor 6, mitochondrial precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AC164162
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  7. NM_016755.3NP_058035.1  ATP synthase-coupling factor 6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_058035.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4, 5, 6 and 7 encode the same protein.
    Source sequence(s)
    AA259963, AI326720, BE995304, U77128
    Consensus CDS
    CCDS28283.1
    UniProtKB/Swiss-Prot
    P97450
    Related
    ENSMUSP00000023608.7, ENSMUST00000023608.13
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    84827871..84835625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246092.2XP_011244394.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011244394.1

    UniProtKB/Swiss-Prot
    P97450
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  2. XM_006522876.2XP_006522939.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006522939.1

    UniProtKB/Swiss-Prot
    P97450
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
  3. XM_006522877.3XP_006522940.1  ATP synthase-coupling factor 6, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006522940.1

    UniProtKB/Swiss-Prot
    P97450
    Conserved Domains (1) summary
    pfam05511
    Location:195
    ATP-synt_F6; Mitochondrial ATP synthase coupling factor 6
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