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PFKM phosphofructokinase, muscle [ Homo sapiens (human) ]

Gene ID: 5213, updated on 1-Jun-2020

Summary

Official Symbol
PFKMprovided by HGNC
Official Full Name
phosphofructokinase, muscleprovided by HGNC
Primary source
HGNC:HGNC:8877
See related
Ensembl:ENSG00000152556 MIM:610681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSD7; PFK1; PFKA; PFKX; PFK-1; PFK-A; ATP-PFK; PPP1R122
Summary
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Expression
Broad expression in heart (RPKM 77.2), brain (RPKM 32.0) and 21 other tissues See more
Orthologs

Genomic context

See PFKM in Genome Data Viewer
Location:
12q13.11
Exon count:
33
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48105253..48146404)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48499656..48540187)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 1 Neighboring gene RNA, U6 small nuclear 1203, pseudogene Neighboring gene V-type proton ATPase subunit F pseudogene Neighboring gene microRNA 6505 Neighboring gene SCO1 cytochrome c oxidase assembly protein pseudogene Neighboring gene ankyrin repeat and SOCS box containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Glycogen storage disease, type VII
MedGen: C0017926 OMIM: 232800 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phosphofructokinase (muscle, PFKM) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8699

Gene Ontology Provided by GOA

Function Evidence Code Pubs
6-phosphofructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
6-phosphofructokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
6-phosphofructokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
6-phosphofructokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
fructose binding IDA
Inferred from Direct Assay
more info
PubMed 
fructose-6-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
canonical glycolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical glycolysis TAS
Traceable Author Statement
more info
 
fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fructose 6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycolytic process through fructose-6-phosphate IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotetramerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
6-phosphofructokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
6-phosphofructokinase complex IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-dependent 6-phosphofructokinase, muscle type
Names
6-phosphofructo-1-kinase
6-phosphofructokinase type A
6-phosphofructokinase, muscle type
phosphofructo-1-kinase isozyme A
phosphofructokinase 1
phosphofructokinase, polypeptide X
phosphofructokinase-M
phosphohexokinase
protein phosphatase 1, regulatory subunit 122
NP_000280.1
NP_001160158.1
NP_001160159.1
NP_001160160.1
NP_001341664.1
NP_001341665.1
NP_001341666.1
NP_001341667.1
NP_001341668.1
NP_001341669.1
NP_001341670.1
NP_001341671.1
NP_001341672.1
NP_001341673.1
NP_001341674.1
NP_001341675.1
NP_001341676.1
NP_001341677.1
NP_001350548.1
XP_005269031.1
XP_005269033.1
XP_005269036.1
XP_011536789.1
XP_016874958.1
XP_024304788.1
XP_024304789.1
XP_024304790.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016199.2 RefSeqGene

    Range
    19112..46152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000289.6NP_000280.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_000280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as type C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BC021203, BU683561, DA525437
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    P08237
    UniProtKB/TrEMBL
    A0A024R0Y5
    Related
    ENSP00000352842.5, ENST00000359794.11
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  2. NM_001166686.2NP_001160158.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    See identical proteins and their annotated locations for NP_001160158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) (also known as TE-PFKM) encodes isoform 1. Variants 1, 7, 8, and 9 encode the same isoform (1).
    Source sequence(s)
    BC000534, BC021203, BU683561, DB081387
    Consensus CDS
    CCDS53786.1
    UniProtKB/Swiss-Prot
    P08237
    Related
    ENSP00000345771.6, ENST00000340802.12
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  3. NM_001166687.1NP_001160159.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_001160159.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as type A) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BU683561, DA560355, Y00698
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    P08237
    UniProtKB/TrEMBL
    A0A024R0Y5
    Related
    ENSP00000309438.7, ENST00000312352.11
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  4. NM_001166688.1NP_001160160.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_001160160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as type B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BU683561, DA761651
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    P08237
    UniProtKB/TrEMBL
    A0A024R0Y5
    Related
    ENSP00000449426.1, ENST00000547587.5
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  5. NM_001354735.1NP_001341664.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS86294.1
    Related
    ENSP00000496597.1, ENST00000642730.1
    Conserved Domains (1) summary
    cd00764
    Location:116877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  6. NM_001354736.1NP_001341665.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS86294.1
    Conserved Domains (1) summary
    cd00764
    Location:116877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  7. NM_001354737.1NP_001341666.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  8. NM_001354738.1NP_001341667.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  9. NM_001354739.1NP_001341668.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  10. NM_001354740.1NP_001341669.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:61822
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  11. NM_001354741.1NP_001341670.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:21782
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  12. NM_001354742.1NP_001341671.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    Related
    ENSP00000450369.2, ENST00000550345.6
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  13. NM_001354743.1NP_001341672.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    Related
    ENSP00000446945.2, ENST00000550924.6
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  14. NM_001354744.1NP_001341673.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    Related
    ENSP00000448253.2, ENST00000551339.6
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  15. NM_001354745.1NP_001341674.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:1745
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  16. NM_001354746.1NP_001341675.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:13732
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  17. NM_001354747.1NP_001341676.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:3724
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  18. NM_001354748.1NP_001341677.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:3724
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  19. NM_001363619.1NP_001350548.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, KU178252
    Consensus CDS
    CCDS86295.1
    Related
    ENSP00000448177.1, ENST00000551804.5
    Conserved Domains (1) summary
    cd00764
    Location:13743
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

RNA

  1. NR_148954.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, U24183
    Related
    ENST00000546964.5
  2. NR_148955.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, AK126020
    Related
    ENST00000547581.5
  3. NR_148956.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
  4. NR_148957.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
  5. NR_148958.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
  6. NR_148959.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48105253..48146404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268976.3XP_005269033.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X1

    See identical proteins and their annotated locations for XP_005269033.1

    Conserved Domains (1) summary
    cd00764
    Location:116877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  2. XM_024449021.1XP_024304789.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X6

    Related
    ENSP00000446829.3, ENST00000549941.7
    Conserved Domains (1) summary
    cd00764
    Location:46807
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  3. XM_024449020.1XP_024304788.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X3

    Conserved Domains (1) summary
    cd00764
    Location:87848
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  4. XM_005268974.1XP_005269031.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X1

    See identical proteins and their annotated locations for XP_005269031.1

    Conserved Domains (1) summary
    cd00764
    Location:116877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  5. XM_017019469.1XP_016874958.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

  6. XM_005268979.1XP_005269036.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X4

    See identical proteins and their annotated locations for XP_005269036.1

    UniProtKB/Swiss-Prot
    P08237
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  7. XM_011538487.1XP_011536789.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X2

    Conserved Domains (2) summary
    cd00764
    Location:116846
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
    TIGR02478
    Location:119827
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type
  8. XM_024449022.1XP_024304790.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X7

    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
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