PFKM phosphofructokinase, muscle [Homo sapiens (human)] - Gene

Summary

Official Symbol: PFKMprovided by HGNC
Official Full Name: phosphofructokinase, muscleprovided by HGNC
Primary source: HGNC:HGNC:8877
See related: Ensembl:ENSG00000152556 MIM:610681
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GSD7; PFK1; PFKA; PFKX; PFK-1; PFK-A; ATP-PFK; PPP1R122
Summary: Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Expression: Broad expression in heart (RPKM 77.2), brain (RPKM 32.0) and 21 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 12q13.11

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
109.20200522	current	GRCh38.p13 (GCF_000001405.39)	12	NC_000012.12 (48105253..48146404)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (48499656..48540187)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors experimentally provide evidence for pulsatile PFK-1 activity-induced synchronized dissociation of PKM2 tetramers and the subsequent accumulation of PKM2 dimers under high levels of fructose-1,6-bisphosphate in HeLa cells.
Title: Glycolytic reprogramming in cancer cells: PKM2 dimer predominance induced by pulsatile PFK-1 activity.
MiR-135 targets phosphofructokinase-1 in the ancreatic ductal adenocarcinoma cells.
Title: MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1.
KLK6 may be the key protease involved in the proteolytic modification of PFK-M.
Title: Kallikrein-related peptidase 6 can cleave human-muscle-type 6-phosphofructo-1-kinase into highly active shorter fragments.
Data indicate that 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase3 (PFKFB3) and phosphofructokinase (PFK1) expression allows discrimination between induced pluripotent stem cells (iPS) and cancer stem cells (CSCs).
Title: The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells.
characterize three PFK1 mutations and show they have distinct effects on allosteric regulation of PFKP activity and lactate production.
Title: Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations.
Gene-based analysis identified an association between breast cancer and the phosphofructokinase-muscle (PFKM) gene on chromosome 12q13.11 that met the genome-wide gene-based threshold of 2.5 x 10(-6).
Title: A genome-wide association study of early-onset breast cancer identifies PFKM as a novel breast cancer gene and supports a common genetic spectrum for breast cancer at any age.
insulin/phosphofructokinase (PFKM), overlaps with an expression quantitative trait loci
Title: Expression of phosphofructokinase in skeletal muscle is influenced by genetic variation and associated with insulin sensitivity.
Asp(543)Ala, a naturally occurring Tarui disease-causing mutation in the activating binding site, causes an increased efficacy of ATP at the inhibitory allosteric binding site.
Title: Altered allosteric regulation of muscle 6-phosphofructokinase causes Tarui disease.
Molecular genetic findings demonstrated the absence of specific genotype-phenotype correlations in PFKM gene mutations.
Title: Clinical features and new molecular findings in muscle phosphofructokinase deficiency (GSD type VII).
eukaryotic Pfk did not evolve from prokaryotic ancestors, reciprocal linkage of functionally opposed allosteric binding sites must have developed independently in prokaryotic and eukaryotic Pfk (convergent evolution).
Title: Functional linkage of adenine nucleotide binding sites in mammalian muscle 6-phosphofructokinase.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Glycogen storage disease, type VII MedGen: C0017926 OMIM: 232800 GeneReviews: Not available	Compare labs

NHGRI GWAS Catalog

Description
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of phosphofructokinase (muscle, PFKM) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17705 (e-PCR)
- UniSTS:25108

SHGC-5984 (e-PCR)
- UniSTS:79131

D11S2560 (e-PCR)
- UniSTS:37928

D8S2279 (e-PCR)
- UniSTS:473907

GDB:375070 (e-PCR)
- UniSTS:156992

GDB:375075 (e-PCR)
- UniSTS:156993

GDB:375078 (e-PCR)
- UniSTS:156994

GDB:375081 (e-PCR)
- UniSTS:156995

GDB:375084 (e-PCR)
- UniSTS:156996

GDB:375087 (e-PCR)
- UniSTS:156997

D10S2448 (e-PCR)
- UniSTS:474444

RH71215 (e-PCR)
- UniSTS:30799

PFKM_8537 (e-PCR)
- UniSTS:468590

D15S1477 (e-PCR)
- UniSTS:474482

D12S2022 (e-PCR)
- UniSTS:65926

PFKM_intron19 (e-PCR)
- UniSTS:512646

GDB:542985 (e-PCR)
- UniSTS:157579

GDB:542997 (e-PCR)
- UniSTS:157582

D12S1157E (e-PCR)
- UniSTS:151439

D11S3114 (e-PCR)
- UniSTS:152207

GDB:581748 (e-PCR)
- UniSTS:157875

GDB:342275 (e-PCR)
- UniSTS:156644

RH17704 (e-PCR)
- UniSTS:59108

Pfkm (e-PCR), detects polymorphism
- UniSTS:507131

RH11170 (e-PCR)
- UniSTS:62204

Homology

Homologs of the PFKM gene: The PFKM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 235 organisms have orthologs with human gene PFKM
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
6-phosphofructokinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
6-phosphofructokinase activity	IDA Inferred from Direct Assay more info	PubMed
6-phosphofructokinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
6-phosphofructokinase activity	ISS Inferred from Sequence or Structural Similarity more info
AMP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ATP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
ATP binding	IDA Inferred from Direct Assay more info	PubMed
fructose binding	IDA Inferred from Direct Assay more info	PubMed
fructose-6-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
identical protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
kinase binding	IPI Inferred from Physical Interaction more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
monosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein C-terminus binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
canonical glycolysis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
canonical glycolysis	TAS Traceable Author Statement more info
fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
fructose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
fructose 6-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
glucose catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
glycolytic process through fructose-6-phosphate	IMP Inferred from Mutant Phenotype more info	PubMed
muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
protein homotetramerization	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
6-phosphofructokinase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
6-phosphofructokinase complex	IDA Inferred from Direct Assay more info	PubMed
apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
cell	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-dependent 6-phosphofructokinase, muscle type

Names: 6-phosphofructo-1-kinase; 6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase, polypeptide X; phosphofructokinase-M; phosphohexokinase; protein phosphatase 1, regulatory subunit 122

NP_000280.1

EC 2.7.1.11

NP_001160158.1

EC 2.7.1.11

NP_001160159.1

EC 2.7.1.11

NP_001160160.1

EC 2.7.1.11

NP_001341664.1

EC 2.7.1.11

NP_001341665.1

EC 2.7.1.11

NP_001341666.1

EC 2.7.1.11

NP_001341667.1

EC 2.7.1.11

NP_001341668.1

EC 2.7.1.11

NP_001341669.1

EC 2.7.1.11

NP_001341670.1

EC 2.7.1.11

NP_001341671.1

EC 2.7.1.11

NP_001341672.1

EC 2.7.1.11

NP_001341673.1

EC 2.7.1.11

NP_001341674.1

EC 2.7.1.11

NP_001341675.1

EC 2.7.1.11

NP_001341676.1

EC 2.7.1.11

NP_001341677.1

EC 2.7.1.11

NP_001350548.1

EC 2.7.1.11

XP_005269031.1

EC 2.7.1.11

XP_005269033.1

EC 2.7.1.11

XP_005269036.1

EC 2.7.1.11

XP_011536789.1

EC 2.7.1.11

XP_016874958.1

EC 2.7.1.11

XP_024304788.1

EC 2.7.1.11

XP_024304789.1

EC 2.7.1.11

XP_024304790.1

EC 2.7.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016199.2 RefSeqGene

Range

19112..46152

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000289.6 → NP_000280.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

See identical proteins and their annotated locations for NP_000280.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as type C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).

Source sequence(s)

BC000534, BC021203, BU683561, DA525437

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

P08237

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000352842.5, ENST00000359794.11

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001166686.2 → NP_001160158.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 1

See identical proteins and their annotated locations for NP_001160158.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) (also known as TE-PFKM) encodes isoform 1. Variants 1, 7, 8, and 9 encode the same isoform (1).

Source sequence(s)

BC000534, BC021203, BU683561, DB081387

Consensus CDS

CCDS53786.1

UniProtKB/Swiss-Prot

P08237

Related

ENSP00000345771.6, ENST00000340802.12

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001166687.1 → NP_001160159.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

See identical proteins and their annotated locations for NP_001160159.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as type A) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).

Source sequence(s)

BC000534, BU683561, DA560355, Y00698

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

P08237

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000309438.7, ENST00000312352.11

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001166688.1 → NP_001160160.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

See identical proteins and their annotated locations for NP_001160160.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as type B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).

Source sequence(s)

BC000534, BU683561, DA761651

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

P08237

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000449426.1, ENST00000547587.5

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354735.1 → NP_001341664.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 3

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS86294.1

Related

ENSP00000496597.1, ENST00000642730.1

Conserved Domains (1) summary

cd00764
Location:116 → 877

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354736.1 → NP_001341665.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 3

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS86294.1

Conserved Domains (1) summary

cd00764
Location:116 → 877

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354737.1 → NP_001341666.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 1

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS53786.1

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354738.1 → NP_001341667.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 1

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS53786.1

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354739.1 → NP_001341668.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 1

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS53786.1

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354740.1 → NP_001341669.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 4

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:61 → 822

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354741.1 → NP_001341670.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 5

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:21 → 782

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354742.1 → NP_001341671.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS8760.1

Related

ENSP00000450369.2, ENST00000550345.6

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354743.1 → NP_001341672.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS8760.1

Related

ENSP00000446945.2, ENST00000550924.6

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354744.1 → NP_001341673.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS8760.1

Related

ENSP00000448253.2, ENST00000551339.6

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354745.1 → NP_001341674.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 6

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:1 → 745

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354746.1 → NP_001341675.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 7

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:13 → 732

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354747.1 → NP_001341676.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 8

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:3 → 724

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354748.1 → NP_001341677.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 8

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:3 → 724

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001363619.1 → NP_001350548.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 9

Status: REVIEWED

Source sequence(s)

AC004801, AC074029, KU178252

Consensus CDS

CCDS86295.1

Related

ENSP00000448177.1, ENST00000551804.5

Conserved Domains (1) summary

cd00764
Location:13 → 743

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

RNA

NR_148954.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029, U24183

Related

ENST00000546964.5
NR_148955.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029, AK126020

Related

ENST00000547581.5
NR_148956.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029
NR_148957.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029
NR_148958.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029
NR_148959.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p13 Primary Assembly

Range

48105253..48146404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005268976.3 → XP_005269033.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X1

See identical proteins and their annotated locations for XP_005269033.1

Conserved Domains (1) summary

cd00764
Location:116 → 877

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_024449021.1 → XP_024304789.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X6

Related

ENSP00000446829.3, ENST00000549941.7

Conserved Domains (1) summary

cd00764
Location:46 → 807

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_024449020.1 → XP_024304788.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X3

Conserved Domains (1) summary

cd00764
Location:87 → 848

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_005268974.1 → XP_005269031.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X1

See identical proteins and their annotated locations for XP_005269031.1

Conserved Domains (1) summary

cd00764
Location:116 → 877

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_017019469.1 → XP_016874958.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X5
XM_005268979.1 → XP_005269036.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X4

See identical proteins and their annotated locations for XP_005269036.1

UniProtKB/Swiss-Prot

P08237

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_011538487.1 → XP_011536789.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X2

Conserved Domains (2) summary

cd00764
Location:116 → 846

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

TIGR02478
Location:119 → 827

6PF1K_euk; 6-phosphofructokinase, eukaryotic type
XM_024449022.1 → XP_024304790.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X7

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...