PFKM phosphofructokinase, muscle [Homo sapiens (human)] - Gene

Summary

Official Symbol: PFKMprovided by HGNC
Official Full Name: phosphofructokinase, muscleprovided by HGNC
Primary source: HGNC:HGNC:8877
See related: Ensembl:ENSG00000152556 MIM:610681; AllianceGenome:HGNC:8877
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GSD7; PFK1; PFKA; PFKX; PFK-1; PFK-A; ATP-PFK; PPP1R122
Summary: Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Expression: Broad expression in heart (RPKM 77.2), brain (RPKM 32.0) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 12q13.11

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (48105353..48146404)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (48066690..48107749)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (48499136..48540187)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM.
Title: Bone marrow mesenchymal stem cell-derived exosomal miR-21a-5p alleviates renal fibrosis by attenuating glycolysis by targeting PFKM.
Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population.
Title: Association of PFKM gene polymorphisms and susceptibility to cryptorchidism in a Chinese Han population.
Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients.
Title: Expression of HK2, PKM2, and PFKM Is Associated with Metastasis and Late Disease Onset in Breast Cancer Patients.
RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.
Title: RNAi-mediated knockdown of PFK1 decreases the invasive capability and metastasis of nasopharyngeal carcinoma cell line, CNE-2.
PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells.
Title: PFK activation is essential for the odontogenic differentiation of human dental pulp stem cells.
TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
Title: TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.
ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM.
Title: ZEB1 enhances Warburg effect to facilitate tumorigenesis and metastasis of HCC by transcriptionally activating PFKM.
Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
Title: Biochemical and transcript level differences between the three human phosphofructokinases show optimisation of each isoform for specific metabolic niches.
Phosphofructokinase-M inhibits cell growth via modulating the FOXO3 pathway in renal cell carcinoma cells.
Title: Phosphofructokinase-M inhibits cell growth via modulating the FOXO3 pathway in renal cell carcinoma cells.
The authors experimentally provide evidence for pulsatile PFK-1 activity-induced synchronized dissociation of PKM2 tetramers and the subsequent accumulation of PKM2 dimers under high levels of fructose-1,6-bisphosphate in HeLa cells.
Title: Glycolytic reprogramming in cancer cells: PKM2 dimer predominance induced by pulsatile PFK-1 activity.

Submit: New GeneRIF Correction See all GeneRIFs (28)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Glycogen storage disease, type VII MedGen: C0017926 OMIM: 232800 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of phosphofructokinase (muscle, PFKM) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH17705 (e-PCR)
- UniSTS:25108

SHGC-5984 (e-PCR)
- UniSTS:79131

D11S2560 (e-PCR)
- UniSTS:37928

D8S2279 (e-PCR)
- UniSTS:473907

GDB:375070 (e-PCR)
- UniSTS:156992

GDB:375075 (e-PCR)
- UniSTS:156993

GDB:375078 (e-PCR)
- UniSTS:156994

GDB:375081 (e-PCR)
- UniSTS:156995

GDB:375084 (e-PCR)
- UniSTS:156996

GDB:375087 (e-PCR)
- UniSTS:156997

D10S2448 (e-PCR)
- UniSTS:474444

RH71215 (e-PCR)
- UniSTS:30799

PFKM_8537 (e-PCR)
- UniSTS:468590

D15S1477 (e-PCR)
- UniSTS:474482

D12S2022 (e-PCR)
- UniSTS:65926

PFKM_intron19 (e-PCR)
- UniSTS:512646

GDB:542985 (e-PCR)
- UniSTS:157579

GDB:542997 (e-PCR)
- UniSTS:157582

D12S1157E (e-PCR)
- UniSTS:151439

D11S3114 (e-PCR)
- UniSTS:152207

GDB:581748 (e-PCR)
- UniSTS:157875

GDB:342275 (e-PCR)
- UniSTS:156644

RH17704 (e-PCR)
- UniSTS:59108

Pfkm (e-PCR), detects polymorphism
- UniSTS:507131

RH11170 (e-PCR)
- UniSTS:62204

Homology

Homologs of the PFKM gene: The PFKM gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 367 organisms have orthologs with human gene PFKM
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 6-phosphofructokinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables 6-phosphofructokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 6-phosphofructokinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 6-phosphofructokinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables fructose binding	IDA Inferred from Direct Assay more info	PubMed
enables fructose-6-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical glycolysis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in fructose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fructose 6-phosphate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in glycogen catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycolysis from storage polysaccharide through glucose-1-phosphate	IEA Inferred from Electronic Annotation more info
involved_in glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycolytic process through fructose-6-phosphate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle cell cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of 6-phosphofructokinase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of 6-phosphofructokinase complex	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in sperm principal piece	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-dependent 6-phosphofructokinase, muscle type

Names: 6-phosphofructo-1-kinase; 6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase, polypeptide X; phosphofructokinase-M; phosphohexokinase; protein phosphatase 1, regulatory subunit 122

NP_000280.1

EC 2.7.1.11

NP_001160158.1

EC 2.7.1.11

NP_001160159.1

EC 2.7.1.11

NP_001160160.1

EC 2.7.1.11

NP_001341664.1

EC 2.7.1.11

NP_001341665.1

EC 2.7.1.11

NP_001341666.1

EC 2.7.1.11

NP_001341667.1

EC 2.7.1.11

NP_001341668.1

EC 2.7.1.11

NP_001341669.1

EC 2.7.1.11

NP_001341670.1

EC 2.7.1.11

NP_001341671.1

EC 2.7.1.11

NP_001341672.1

EC 2.7.1.11

NP_001341673.1

EC 2.7.1.11

NP_001341674.1

EC 2.7.1.11

NP_001341675.1

EC 2.7.1.11

NP_001341676.1

EC 2.7.1.11

NP_001341677.1

EC 2.7.1.11

NP_001350548.1

EC 2.7.1.11

XP_005269031.1

EC 2.7.1.11

XP_005269033.1

EC 2.7.1.11

XP_011536789.2

EC 2.7.1.11

XP_016874958.1

EC 2.7.1.11

XP_024304788.1

EC 2.7.1.11

XP_024304789.1

EC 2.7.1.11

XP_024304790.1

EC 2.7.1.11

XP_047284955.1

EC 2.7.1.11

XP_047284956.1

EC 2.7.1.11

XP_047284957.1

EC 2.7.1.11

XP_047284958.1

EC 2.7.1.11

XP_047284959.1

EC 2.7.1.11

XP_047284960.1

EC 2.7.1.11

XP_054228244.1

EC 2.7.1.11

XP_054228245.1

EC 2.7.1.11

XP_054228246.1

EC 2.7.1.11

XP_054228247.1

EC 2.7.1.11

XP_054228248.1

EC 2.7.1.11

XP_054228249.1

EC 2.7.1.11

XP_054228250.1

EC 2.7.1.11

XP_054228251.1

EC 2.7.1.11

XP_054228252.1

EC 2.7.1.11

XP_054228253.1

EC 2.7.1.11

XP_054228254.1

EC 2.7.1.11

XP_054228255.1

EC 2.7.1.11

XP_054228256.1

EC 2.7.1.11

XP_054228257.1

EC 2.7.1.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016199.2 RefSeqGene

Range

19112..46152

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1177

mRNA and Protein(s)

NM_000289.6 → NP_000280.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

See identical proteins and their annotated locations for NP_000280.1

Status: REVIEWED

Description

Transcript Variant: This variant (4, also known as type C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).

Source sequence(s)

BC000534, BC021203, BU683561, DA525437

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

P08237, Q6ZTT1

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000352842.5, ENST00000359794.11

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001166686.2 → NP_001160158.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 1

See identical proteins and their annotated locations for NP_001160158.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) (also known as TE-PFKM) encodes isoform 1. Variants 1, 7, 8, and 9 encode the same isoform (1).

Source sequence(s)

BC000534, BC021203, BU683561, DB081387

Consensus CDS

CCDS53786.1

UniProtKB/Swiss-Prot

P08237

Related

ENSP00000345771.6, ENST00000340802.12

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001166687.2 → NP_001160159.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

See identical proteins and their annotated locations for NP_001160159.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, also known as type A) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).

Source sequence(s)

BC000534, BU683561, DA560355, Y00698

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

P08237, Q6ZTT1

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000309438.7, ENST00000312352.11

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001166688.2 → NP_001160160.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

See identical proteins and their annotated locations for NP_001160160.1

Status: REVIEWED

Description

Transcript Variant: This variant (3, also known as type B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).

Source sequence(s)

BC000534, BU683561, DA761651

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

P08237, Q6ZTT1

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000449426.1, ENST00000547587.5

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354735.1 → NP_001341664.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 3

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS86294.1

UniProtKB/TrEMBL

A0A2R8Y891

Related

ENSP00000496597.1, ENST00000642730.1

Conserved Domains (1) summary

cd00764
Location:116 → 877

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354736.1 → NP_001341665.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 3

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS86294.1

UniProtKB/TrEMBL

A0A2R8Y891

Conserved Domains (1) summary

cd00764
Location:116 → 877

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354737.1 → NP_001341666.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 1

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS53786.1

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354738.1 → NP_001341667.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 1

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS53786.1

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354739.1 → NP_001341668.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 1

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS53786.1

Conserved Domains (1) summary

cd00764
Location:84 → 845

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354740.1 → NP_001341669.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 4

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:61 → 822

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354741.2 → NP_001341670.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 5

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:21 → 782

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354742.2 → NP_001341671.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

Q6ZTT1

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000450369.2, ENST00000550345.6

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354743.2 → NP_001341672.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

Q6ZTT1

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000446945.2, ENST00000550924.6

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354744.2 → NP_001341673.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 2

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Consensus CDS

CCDS8760.1

UniProtKB/Swiss-Prot

Q6ZTT1

UniProtKB/TrEMBL

A0A024R0Y5

Related

ENSP00000448253.2, ENST00000551339.6

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354745.2 → NP_001341674.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 6

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:1 → 745

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354746.2 → NP_001341675.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 7

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:13 → 732

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354747.2 → NP_001341676.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 8

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:3 → 724

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001354748.2 → NP_001341677.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 8

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

Conserved Domains (1) summary

cd00764
Location:3 → 724

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
NM_001363619.2 → NP_001350548.1 ATP-dependent 6-phosphofructokinase, muscle type isoform 9

Status: REVIEWED

Source sequence(s)

AC004801, AC074029, KU178252

Consensus CDS

CCDS86295.1

UniProtKB/TrEMBL

A0A0S2Z4I1

Related

ENSP00000448177.1, ENST00000551804.5

Conserved Domains (1) summary

cd00764
Location:13 → 743

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

RNA

NR_148954.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029, U24183

Related

ENST00000546964.5
NR_148955.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029, AK126020

Related

ENST00000547581.5
NR_148956.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029
NR_148957.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029
NR_148958.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029
NR_148959.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC004801, AC074029

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000012.12 Reference GRCh38.p14 Primary Assembly

Range

48105353..48146404

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047428999.1 → XP_047284955.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X1
XM_011538487.2 → XP_011536789.2 ATP-dependent 6-phosphofructokinase, muscle type isoform X2
XM_047429000.1 → XP_047284956.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X3
XM_005268976.4 → XP_005269033.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X5

See identical proteins and their annotated locations for XP_005269033.1

UniProtKB/TrEMBL

A0A2R8Y891

Conserved Domains (1) summary

cd00764
Location:116 → 877

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_047429001.1 → XP_047284957.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X4
XM_024449020.2 → XP_024304788.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X6

Conserved Domains (1) summary

cd00764
Location:87 → 848

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_047429002.1 → XP_047284958.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X7
XM_024449021.2 → XP_024304789.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X9

Conserved Domains (1) summary

cd00764
Location:46 → 807

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_047429004.1 → XP_047284960.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X11

Related

ENSP00000446829.3, ENST00000549941.7
XM_017019469.2 → XP_016874958.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X8
XM_005268974.2 → XP_005269031.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X5

See identical proteins and their annotated locations for XP_005269031.1

UniProtKB/TrEMBL

A0A2R8Y891

Conserved Domains (1) summary

cd00764
Location:116 → 877

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
XM_047429003.1 → XP_047284959.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X10
XM_024449022.2 → XP_024304790.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X12

UniProtKB/Swiss-Prot

Q6ZTT1

UniProtKB/TrEMBL

A0A024R0Y5

Conserved Domains (1) summary

cd00764
Location:13 → 774

Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

Alternate T2T-CHM13v2.0

Genomic

NC_060936.1 Alternate T2T-CHM13v2.0

Range

48066690..48107749

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054372275.1 → XP_054228250.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X14
XM_054372271.1 → XP_054228246.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X5
XM_054372269.1 → XP_054228244.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X4
XM_054372272.1 → XP_054228247.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X13
XM_054372273.1 → XP_054228248.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X6
XM_054372276.1 → XP_054228251.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X7
XM_054372279.1 → XP_054228254.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X9
XM_054372281.1 → XP_054228256.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X11
XM_054372277.1 → XP_054228252.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X8
XM_054372270.1 → XP_054228245.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X5
XM_054372274.1 → XP_054228249.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X14
XM_054372278.1 → XP_054228253.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X8
XM_054372280.1 → XP_054228255.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X10
XM_054372282.1 → XP_054228257.1 ATP-dependent 6-phosphofructokinase, muscle type isoform X12