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PFKM phosphofructokinase, muscle [ Homo sapiens (human) ]

Gene ID: 5213, updated on 17-Jun-2019

Summary

Official Symbol
PFKMprovided by HGNC
Official Full Name
phosphofructokinase, muscleprovided by HGNC
Primary source
HGNC:HGNC:8877
See related
Ensembl:ENSG00000152556 MIM:610681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSD7; PFK1; PFKA; PFKX; PFK-1; PFK-A; ATP-PFK; PPP1R122
Summary
Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
Expression
Broad expression in heart (RPKM 77.2), brain (RPKM 32.0) and 21 other tissues See more
Orthologs

Genomic context

See PFKM in Genome Data Viewer
Location:
12q13.11
Exon count:
33
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (48105253..48146404)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (48499656..48540187)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 1 Neighboring gene RNA, U6 small nuclear 1203, pseudogene Neighboring gene V-type proton ATPase subunit F pseudogene Neighboring gene microRNA 6505 Neighboring gene SCO1 cytochrome c oxidase assembly protein pseudogene Neighboring gene ankyrin repeat and SOCS box containing 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Glycogen storage disease, type VII
MedGen: C0017926 OMIM: 232800 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of phosphofructokinase (muscle, PFKM) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Biosynthesis of amino acids, organism-specific biosystem (from KEGG)
    Biosynthesis of amino acids, organism-specific biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Biosynthesis of amino acids, conserved biosystem (from KEGG)
    Biosynthesis of amino acids, conserved biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Central carbon metabolism in cancer, organism-specific biosystem (from KEGG)
    Central carbon metabolism in cancer, organism-specific biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
  • Central carbon metabolism in cancer, conserved biosystem (from KEGG)
    Central carbon metabolism in cancer, conserved biosystemMalignant transformation of cells requires specific adaptations of cellular metabolism to support growth and survival. In the early twentieth century, Otto Warburg established that there are fundamen...
  • Fructose and mannose metabolism, organism-specific biosystem (from KEGG)
    Fructose and mannose metabolism, organism-specific biosystem
    Fructose and mannose metabolism
  • Fructose and mannose metabolism, conserved biosystem (from KEGG)
    Fructose and mannose metabolism, conserved biosystem
    Fructose and mannose metabolism
  • Galactose metabolism, organism-specific biosystem (from KEGG)
    Galactose metabolism, organism-specific biosystem
    Galactose metabolism
  • Galactose metabolism, conserved biosystem (from KEGG)
    Galactose metabolism, conserved biosystem
    Galactose metabolism
  • Glucose metabolism, organism-specific biosystem (from REACTOME)
    Glucose metabolism, organism-specific biosystemGlucose is the major form in which dietary sugars are made available to cells of the human body. Its breakdown is a major source of energy for all cells, and is essential for the brain and red blood ...
  • Glycolysis, organism-specific biosystem (from REACTOME)
    Glycolysis, organism-specific biosystemThe reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructo...
  • Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystem (from KEGG)
    Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
  • Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystem (from KEGG)
    Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Central carbohydrate metabolism
  • Glycolysis / Gluconeogenesis, organism-specific biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, organism-specific biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Glycolysis / Gluconeogenesis, conserved biosystem (from KEGG)
    Glycolysis / Gluconeogenesis, conserved biosystemGlycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (energy) and NADH (reducing power). It is a central pathway that produces important precursor metabol...
  • Glycolysis and Gluconeogenesis, organism-specific biosystem (from WikiPathways)
    Glycolysis and Gluconeogenesis, organism-specific biosystemGlycolysis is the metabolic pathway that converts glucose C6H12O6, into pyruvate, CH3COCOO? + H+. The free energy released in this process is used to form the ATP and NADH. Gluconeogenesis is a metab...
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Pentose phosphate pathway, organism-specific biosystem (from KEGG)
    Pentose phosphate pathway, organism-specific biosystemThe pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathwa...
  • Pentose phosphate pathway, conserved biosystem (from KEGG)
    Pentose phosphate pathway, conserved biosystemThe pentose phosphate pathway is a process of glucose turnover that produces NADPH as reducing equivalents and pentoses as essential parts of nucleotides. There are two different phases in the pathwa...
  • RNA degradation, organism-specific biosystem (from KEGG)
    RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • RNA degradation, conserved biosystem (from KEGG)
    RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
  • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
    Validated targets of C-MYC transcriptional activation, organism-specific biosystem
    Validated targets of C-MYC transcriptional activation
  • glycolysis, organism-specific biosystem (from BIOCYC)
    glycolysis, organism-specific biosystemGeneral Background Glycolysis is one of the oldest metabolic pathways which occurs within the cell cytosol in nearly all organisms. The free energy released by the conversion of : Glucopyranose "glu...
  • glycolysis III (from glucose), conserved biosystem (from BIOCYC)
    glycolysis III (from glucose), conserved biosystemGeneral Background Glycolysis, which was first studied as a pathway for the utilization of glucose, is one of the major pathways of central metabolism, the other two being the |FRAME:PENTOSE-P-PWY| ...
  • homolactic fermentation, conserved biosystem (from BIOCYC)
    homolactic fermentation, conserved biosystemGeneral Background Lactic acid fermentation is a process by which sugars such as glucose, fructose, and sucrose are converted into cellular energy and the metabolic byproduct lactate. It occurs in m...
  • superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle, organism-specific biosystem (from BIOCYC)
    superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle, organism-specific biosystem
    superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8699

Gene Ontology Provided by GOA

Function Evidence Code Pubs
6-phosphofructokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
6-phosphofructokinase activity IDA
Inferred from Direct Assay
more info
PubMed 
6-phosphofructokinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
6-phosphofructokinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
fructose binding IDA
Inferred from Direct Assay
more info
PubMed 
fructose-6-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
canonical glycolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical glycolysis TAS
Traceable Author Statement
more info
 
fructose 1,6-bisphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fructose 6-phosphate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
fructose 6-phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucose catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycolytic process through fructose-6-phosphate IMP
Inferred from Mutant Phenotype
more info
PubMed 
muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
protein homotetramerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
6-phosphofructokinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
6-phosphofructokinase complex IDA
Inferred from Direct Assay
more info
PubMed 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ATP-dependent 6-phosphofructokinase, muscle type
Names
6-phosphofructo-1-kinase
6-phosphofructokinase type A
6-phosphofructokinase, muscle type
phosphofructo-1-kinase isozyme A
phosphofructokinase 1
phosphofructokinase, polypeptide X
phosphofructokinase-M
phosphohexokinase
protein phosphatase 1, regulatory subunit 122
NP_000280.1
NP_001160158.1
NP_001160159.1
NP_001160160.1
NP_001341664.1
NP_001341665.1
NP_001341666.1
NP_001341667.1
NP_001341668.1
NP_001341669.1
NP_001341670.1
NP_001341671.1
NP_001341672.1
NP_001341673.1
NP_001341674.1
NP_001341675.1
NP_001341676.1
NP_001341677.1
NP_001350548.1
XP_005269031.1
XP_005269033.1
XP_005269036.1
XP_011536789.1
XP_016874958.1
XP_024304788.1
XP_024304789.1
XP_024304790.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016199.2 RefSeqGene

    Range
    19112..46152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000289.6NP_000280.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_000280.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as type C) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BC021203, BU683561, DA525437
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    P08237
    UniProtKB/TrEMBL
    A0A024R0Y5
    Related
    ENSP00000352842.5, ENST00000359794.11
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  2. NM_001166686.2NP_001160158.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    See identical proteins and their annotated locations for NP_001160158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) (also known as TE-PFKM) encodes isoform 1. Variants 1, 7, 8, and 9 encode the same isoform (1).
    Source sequence(s)
    BC000534, BC021203, BU683561, DB081387
    Consensus CDS
    CCDS53786.1
    UniProtKB/Swiss-Prot
    P08237
    Related
    ENSP00000345771.6, ENST00000340802.12
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  3. NM_001166687.1NP_001160159.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_001160159.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as type A) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BU683561, DA560355, Y00698
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    P08237
    UniProtKB/TrEMBL
    A0A024R0Y5
    Related
    ENSP00000309438.7, ENST00000312352.11
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  4. NM_001166688.1NP_001160160.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    See identical proteins and their annotated locations for NP_001160160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as type B) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 3, 4, 12, 13, and 14 encode the same isoform (2).
    Source sequence(s)
    BC000534, BU683561, DA761651
    Consensus CDS
    CCDS8760.1
    UniProtKB/Swiss-Prot
    P08237
    UniProtKB/TrEMBL
    A0A024R0Y5
    Related
    ENSP00000449426.1, ENST00000547587.5
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  5. NM_001354735.1NP_001341664.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS86294.1
    Related
    ENSP00000496597.1, ENST00000642730.1
    Conserved Domains (1) summary
    cd00764
    Location:116877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  6. NM_001354736.1NP_001341665.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS86294.1
    Conserved Domains (1) summary
    cd00764
    Location:116877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  7. NM_001354737.1NP_001341666.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  8. NM_001354738.1NP_001341667.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  9. NM_001354739.1NP_001341668.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS53786.1
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  10. NM_001354740.1NP_001341669.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:61822
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  11. NM_001354741.1NP_001341670.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:21782
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  12. NM_001354742.1NP_001341671.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    Related
    ENSP00000450369.2, ENST00000550345.6
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  13. NM_001354743.1NP_001341672.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    Related
    ENSP00000446945.2, ENST00000550924.6
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  14. NM_001354744.1NP_001341673.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Consensus CDS
    CCDS8760.1
    Related
    ENSP00000448253.2, ENST00000551339.6
    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  15. NM_001354745.1NP_001341674.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:1745
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  16. NM_001354746.1NP_001341675.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:13732
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  17. NM_001354747.1NP_001341676.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:3724
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  18. NM_001354748.1NP_001341677.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
    Conserved Domains (1) summary
    cd00764
    Location:3724
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  19. NM_001363619.1NP_001350548.1  ATP-dependent 6-phosphofructokinase, muscle type isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, KU178252
    Consensus CDS
    CCDS86295.1
    Conserved Domains (1) summary
    cd00764
    Location:13743
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

RNA

  1. NR_148954.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, U24183
    Related
    ENST00000546964.5
  2. NR_148955.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029, AK126020
    Related
    ENST00000547581.5
  3. NR_148956.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
  4. NR_148957.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
  5. NR_148958.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029
  6. NR_148959.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004801, AC074029

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    48105253..48146404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268976.3XP_005269033.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X1

    See identical proteins and their annotated locations for XP_005269033.1

    Conserved Domains (1) summary
    cd00764
    Location:116877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  2. XM_024449021.1XP_024304789.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X6

    Conserved Domains (1) summary
    cd00764
    Location:46807
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  3. XM_024449020.1XP_024304788.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X3

    Conserved Domains (1) summary
    cd00764
    Location:87848
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  4. XM_005268974.1XP_005269031.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X1

    See identical proteins and their annotated locations for XP_005269031.1

    Conserved Domains (1) summary
    cd00764
    Location:116877
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  5. XM_017019469.1XP_016874958.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X5

  6. XM_005268979.1XP_005269036.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X4

    See identical proteins and their annotated locations for XP_005269036.1

    UniProtKB/Swiss-Prot
    P08237
    Conserved Domains (1) summary
    cd00764
    Location:84845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
  7. XM_011538487.1XP_011536789.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X2

    Conserved Domains (2) summary
    cd00764
    Location:116846
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
    TIGR02478
    Location:119827
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type
  8. XM_024449022.1XP_024304790.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X7

    Conserved Domains (1) summary
    cd00764
    Location:13774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
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