Ccnc cyclin C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccncprovided by MGI
Official Full Name: cyclin Cprovided by MGI
Primary source: MGI:MGI:1858199
See related: Ensembl:ENSMUSG00000028252 AllianceGenome:MGI:1858199
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CG1C
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and identical protein binding activity. Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in negative regulation of triglyceride metabolic process; positive regulation of transcription by RNA polymerase II; and protein ubiquitination. Part of mediator complex. Is expressed in central nervous system; limb; and retina. Orthologous to human CCNC (cyclin C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E18 (RPKM 5.3), CNS E14 (RPKM 4.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 A3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (21727701..21759922)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (21727701..21759922)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.
Title: Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.
The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription.
Title: The extent of cyclin C promoter occupancy directs changes in stress-dependent transcription.
his study uncovers new synergistic activities of Pten and cyclin C to promote quiescence through maintenance of p21 and p53.
Title: Synergistic repression of thyroid hyperplasia by cyclin C and Pten.
cyclin C binding stimulates the reduction of low-GTPase activity Drp1 oligomers into dimers capable of producing high-GTPase activity filaments.
Title: Cyclin C directly stimulates Drp1 GTP affinity to mediate stress-induced mitochondrial hyperfission.
these data indicate that CycC activates adipogenesis in part by stimulating the transcriptional activity of C/EBPalpha.
Title: Cyclin C regulates adipogenesis by stimulating transcriptional activity of CCAAT/enhancer-binding protein α.
our results suggest that mTORC1 activation in NAFLD and insulin resistance results in down-regulation of the CDK8-CycC complex and elevation of lipogenic protein expression.
Title: mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).
cyclin C connects stress-induced mitochondrial hyperfission and programmed cell death in mammalian cells.
Title: Cyclin C mediates stress-induced mitochondrial fission and apoptosis.
cyclin-C-CDK complexes phosphorylate the Notch1 intracellular domain (ICN1) and promote ICN1 degradation
Title: Cyclin C is a haploinsufficient tumour suppressor.
Data show that the isolated 3.6-KB promoter fragment alone is not sufficient for the complete physiological modulation of cyclin C RNA.
Title: 3.6-KB mouse cyclin C promoter fragment is predominantly active in the testis.
Results identify LSF as only the second known target (in addition to pRb) of cyclin C/CDK2 activity during progression from quiescence to early G(1).
Title: Phosphorylation by cyclin C/cyclin-dependent kinase 2 following mitogenic stimulation of murine fibroblasts inhibits transcriptional activity of LSF during G1 progression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U62638 (e-PCR)
- UniSTS:125774

D4Mit345 (e-PCR), detects polymorphism
- UniSTS:130138

D4Mit345.1 (e-PCR), detects polymorphism
- UniSTS:130139

AI451004 (e-PCR)
- UniSTS:164230

RH136342 (e-PCR)
- UniSTS:210332

D4Mit98 (e-PCR), detects polymorphism
- UniSTS:130216

Homology

Homologs of the Ccnc gene: The Ccnc gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs from Annotation Pipeline: 497 organisms have orthologs with human gene Ccnc
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G0 to G1 transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cyclin-C

Names: dJ199J3.4 (cyclin C)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001122982.2 → NP_001116454.1 cyclin-C isoform 2

See identical proteins and their annotated locations for NP_001116454.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 3' exon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter by an amino acid and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK009615, AK037957, AK135472, AK153035, BQ175960

Consensus CDS

CCDS51127.1

UniProtKB/TrEMBL

A0A6P5PKP1, A0A8C6GXW7, Q3U6Q7, Q3UXL9, Q8CAS3

Related

ENSMUSP00000103875.3, ENSMUST00000108240.3

Conserved Domains (2) summary

cd20513
Location:40 → 146

CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins

cd20514
Location:154 → 245

CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
NM_001290420.1 → NP_001277349.1 cyclin-C isoform 3

See identical proteins and their annotated locations for NP_001277349.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 3' terminal exon, compared to variant 1. It encodes isoform 3, which has a shorter C-terminus compared to isoform 1.

Source sequence(s)

AK037957, AK135472, BE653196

Consensus CDS

CCDS71350.1

UniProtKB/TrEMBL

A0A8C6GV63, Q3UXL9, Q8CAS3

Related

ENSMUSP00000113682.2, ENSMUST00000120679.8

Conserved Domains (1) summary

cl28538
Location:1 → 212

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
NM_001290422.1 → NP_001277351.1 cyclin-C isoform 2

See identical proteins and their annotated locations for NP_001277351.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains an alternate exon in the 3' coding region, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which is shorter by an amino acid and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK037957, AL772187, BC120649

Consensus CDS

CCDS51127.1

UniProtKB/Swiss-Prot

Q62447

UniProtKB/TrEMBL

A0A6P5PKP1, A0A8C6GXW7, Q8CAS3

Related

ENSMUSP00000069076.5, ENSMUST00000065928.11

Conserved Domains (2) summary

cd20513
Location:40 → 146

CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins

cd20514
Location:154 → 245

CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
NM_016746.4 → NP_058026.2 cyclin-C isoform 1

See identical proteins and their annotated locations for NP_058026.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AK037957, AL772187, BC120649

Consensus CDS

CCDS17998.1

UniProtKB/Swiss-Prot

Q62447, Q9WUZ4

UniProtKB/TrEMBL

A0A6P5PS16, A0A8C6GX91, Q8CAS3

Related

ENSMUSP00000100062.2, ENSMUST00000102997.8

Conserved Domains (2) summary

cd20513
Location:40 → 146

CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins

cd20514
Location:154 → 245

CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

21727701..21759922

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164233.1 → XP_036020126.1 cyclin-C isoform X1

Conserved Domains (2) summary

cd20513
Location:33 → 139

CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins

cd20514
Location:147 → 238

CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins
XM_036164234.1 → XP_036020127.1 cyclin-C isoform X2

Conserved Domains (2) summary

cd20513
Location:33 → 139

CYCLIN_CCNC_rpt1; first cyclin box found in cyclin-C (CCNC) and similar proteins

cd20514
Location:147 → 238

CYCLIN_CCNC_rpt2; second cyclin box found in cyclin-C (CCNC) and similar proteins