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CCNC cyclin C [ Homo sapiens (human) ]

Gene ID: 892, updated on 5-Jul-2020

Summary

Official Symbol
CCNCprovided by HGNC
Official Full Name
cyclin Cprovided by HGNC
Primary source
HGNC:HGNC:1581
See related
Ensembl:ENSG00000112237 MIM:123838
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CycC; SRB11; hSRB11
Summary
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 29.5), gall bladder (RPKM 20.6) and 25 other tissues See more
Orthologs

Genomic context

See CCNC in Genome Data Viewer
Location:
6q16.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (99542387..99568814, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99990263..100016849, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene PNN interacting serine and arginine rich protein Neighboring gene uncharacterized LOC101927365 Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene ubiquitin specific peptidase 45 Neighboring gene CCNC and PRDM13 intergenic region DNase I hypersensitve site DHS6S1 Neighboring gene ribosomal protein S3 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes cyclin c, during Tat-mediated transactivation of the HIV-1 LTR PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
host cell nucleus IEA
Inferred from Electronic Annotation
more info
 
mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-C
Names
SRB11 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013399.1NP_001013417.1  cyclin-C isoform b

    See identical proteins and their annotated locations for NP_001013417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1, that results in the use of a downstream translational start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BC056153, BM788717
    Consensus CDS
    CCDS47461.1
    UniProtKB/Swiss-Prot
    P24863
    UniProtKB/TrEMBL
    Q7Z4L3
    Related
    ENSP00000430014.1, ENST00000523799.5
    Conserved Domains (1) summary
    cl28538
    Location:4184
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
  2. NM_001363537.1NP_001350466.1  cyclin-C isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL137784
    Consensus CDS
    CCDS87420.1
    Related
    ENSP00000430381.1, ENST00000520371.5
    Conserved Domains (1) summary
    cl28538
    Location:1212
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
  3. NM_005190.4NP_005181.2  cyclin-C isoform a

    See identical proteins and their annotated locations for NP_005181.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC041123, BC056153
    Consensus CDS
    CCDS34502.1
    UniProtKB/Swiss-Prot
    P24863
    UniProtKB/TrEMBL
    Q7Z4L3
    Related
    ENSP00000428982.1, ENST00000520429.6
    Conserved Domains (1) summary
    cl28538
    Location:1269
    CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    99542387..99568814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536232.3XP_011534534.1  cyclin-C isoform X2

    Conserved Domains (1) summary
    cd00043
    Location:48143
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  2. XM_017011436.2XP_016866925.1  cyclin-C isoform X3

RNA

  1. XR_001743714.2 RNA Sequence

    Related
    ENST00000326298.8
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