5ICP,1ZP2,4F6S,5XQX


Conserved Protein Domain Family
CYCLIN_CCNC_rpt1
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cd20513: CYCLIN_CCNC_rpt1 
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first cyclin box found in cyclin-C (CCNC) and similar proteins
CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.
Links
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Statistics
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PSSM-Id: 410217
Aligned: 41 rows
Threshold Bit Score: 99.5915
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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CDK interface
Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:CDK interface [polypeptide binding site]
Evidence:
  • Structure:5ICP; Homo sapiens CCNC in complex with CDK8, contacts at 4A
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                   #  ####              
5ICP_B        43 LQIFFTNVIQALGEHLkl------rQQVIATATVYFKRFYARyslksidpVLMAPTCVFLASKVEEfgvvSNTRLIAAAT 116 human
XP_653258     41 CHIEIGKYIRKLCSLTrrnm-iktaIRIHSSSIIYYRRFYAQrliteidpRLIAATCVFFSSKVEGc--lISPHSIIEYS 117 Entamoeba histo...
XP_002682418  54 ILMSTIKNLKDIGKKVgg------hLRVVSTAMVYFKRFYCQnsisdcdpALLGAAALLLASKIEEc--pLNAKNIHQIC 125 Naegleria grube...
XP_005830716  51 LRIHMSTFISQLGRNLhvk----vrQRVISTATVYLARFYYHnsykdfhpHLIAATALYLASKVEE----SPVSHIVSAL 122 Guillardia thet...
PNW85166      40 LNVFFCTSIAELAKQLkl------rQRVAATAMVYFRRTYLCnnfcrmdpRLVYVASLYLACKAEEs--lVQAKHLVGHA 111 Chlamydomonas r...
PSC74209      40 LHAHFVAYMQQLARSMatesepllrQRVVGTAAIYFRKLYLQqsfctadpRHMAPACLFLASKTEEt--pIHSKLLLHYA 117 Micractinium co...
PXF46276      44 IKVIYSQIISTLAMKSkl------rQRVAATAIVYYRRFFARnavrdhdpRLIAPVALYLAAKAEEh--tLAAKIVVAQM 115 Gracilariopsis ...
SPQ93872      41 LRLYFVDFLTTLGTGKhln----lrQRIISTAIVYFKRFYLDqsfiefdpYLVSITMLFLSAKAEEc--gIHANVMINAA 114 Plasmodiophora ...
KXN72391      83 TIAYFEAFLTKLPNLN---------ISIQNTALIYFKRFYLKksildfnpKQMGVICIYLASKVENl--pLPINHEYFAL 151 Conidiobolus co...
Q9FJK6        40 IKFHMSNHIMKLAQHIkv------rQRVVATAITYMRRVYIRksmvefepRLVALTCLYLASKAEEs--iVQARNLVFYI 111 thale cress

Feature 1                                   ## ### ### 
5ICP_B       117 SVLktrfsyaf-----pkefpyrMNHILECEFYLLELM 149 human
XP_653258    118 KQIlef--------------pfkIQQITDTERILIEAL 141 Entamoeba histolytica HM-1:IMSS
XP_002682418 126 LGKetpssqnydtkdvttlfpypLQQILECELYLMEQL 163 Naegleria gruberi strain NEG-M
XP_005830716 123 KELhqtkwp--------keesydIRDIVDAEYFLMEEL 152 Guillardia theta CCMP2712
PNW85166     112 KSYrkw--------------pydVKDLLDMEMVLLEDL 135 Chlamydomonas reinhardtii
PSC74209     118 RRLctkqga---------lpppdLLQLVTAEAVLLEQL 146 Micractinium conductrix
PXF46276     116 ADIyqadh----------pypysVIHVYDYEFKLIAAL 143 Gracilariopsis chorda
SPQ93872     115 AELipsf-------------pytAKHLFECEFFALELL 139 Plasmodiophora brassicae
KXN72391     152 TKLt------------------sKNEIEKLELILAEAL 171 Conidiobolus coronatus NRRL 28638
Q9FJK6       112 KRLypdey-----------nkyeLKDILGMEMKVLEAL 138 thale cress

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