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Ppp2r1a protein phosphatase 2, regulatory subunit A, alpha [ Mus musculus (house mouse) ]

Gene ID: 51792, updated on 11-Apr-2024

Summary

Official Symbol
Ppp2r1aprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit A, alphaprovided by MGI
Primary source
MGI:MGI:1926334
See related
Ensembl:ENSMUSG00000007564 AllianceGenome:MGI:1926334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PP2A; PR65; 6330556D22Rik
Summary
Enables protein serine/threonine phosphatase activity. Acts upstream of or within several processes, including nuclear division; peptidyl-serine dephosphorylation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in cytosol and glutamatergic synapse. Part of protein phosphatase type 2A complex. Is active in synapse. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 36. Orthologous to human PPP2R1A (protein phosphatase 2 scaffold subunit Aalpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 147.1), CNS E18 (RPKM 140.4) and 28 other tissues See more
Orthologs
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Genomic context

See Ppp2r1a in Genome Data Viewer
Location:
17 A3.2; 17 11.4 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21165716..21186167)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (20945454..20965905)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 1 receptor 232 Neighboring gene vomeronasal 1 receptor, pseudogene 144 Neighboring gene STARR-positive B cell enhancer ABC_E264 Neighboring gene vomeronasal 1 receptor, pseudogene 145 Neighboring gene STARR-seq mESC enhancer starr_42003 Neighboring gene vomeronasal 1 receptor 233

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein antigen binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein phosphatase type 2A complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Names
protein phosphatase PP2A
serine/threonine protein phosphatase A subunit type 2A
NP_058587.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016891.3NP_058587.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

    See identical proteins and their annotated locations for NP_058587.1

    Status: PROVISIONAL

    Source sequence(s)
    AC109204
    Consensus CDS
    CCDS28432.1
    UniProtKB/Swiss-Prot
    Q76MZ3
    Related
    ENSMUSP00000007708.8, ENSMUST00000007708.14
    Conserved Domains (3) summary
    COG1413
    Location:187462
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:245269
    HEAT; HEAT repeat [structural motif]
    pfam02985
    Location:166196
    HEAT; HEAT repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    21165716..21186167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)