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PPP2R1A protein phosphatase 2 scaffold subunit Aalpha [ Homo sapiens (human) ]

Gene ID: 5518, updated on 4-Oct-2020

Summary

Official Symbol
PPP2R1Aprovided by HGNC
Official Full Name
protein phosphatase 2 scaffold subunit Aalphaprovided by HGNC
Primary source
HGNC:HGNC:9302
See related
Ensembl:ENSG00000105568 MIM:605983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRD36; PP2AA; PR65A; PP2AAALPHA; PP2A-Aalpha
Summary
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in heart (RPKM 78.3), adrenal (RPKM 73.7) and 25 other tissues See more
Orthologs

Genomic context

See PPP2R1A in Genome Data Viewer
Location:
19q13.41
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52190052..52229518)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52693055..52729678)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L37 pseudogene 23 Neighboring gene zinc finger protein 836 Neighboring gene microRNA 6801 Neighboring gene uncharacterized LOC105372449 Neighboring gene vomeronasal 1 receptor 99 pseudogene Neighboring gene vomeronasal 1 receptor 100 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr ATR-induced phosphorylation of Chk1-Ser(345) requires PP2A only when Vpr activates ATR PubMed
vpr Depletion of A-alpha and C-beta subunits of PP2A reduces Vpr-induced G2 arrest to the same extent as depletion of ATM and Rad3-related (ATR) PubMed
vpr A-alpha and C-beta subunits of PP2A are required for the HIV-1 Vpr-induced cell cycle G2 arrest PubMed
vpr Amino-acid peptide sequence (residues 77-92) of HIV-1 Vpr binds to PP2A1. The sequence from HIV-1 89.6 strain is a cell penetrating and death domain PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
Vpu vpu IFN-alpha and IFN-beta increases SCYL2 expression and the increase induces PP2A-mediated dephosphorylation of Vpu, suggesting that SCYL2 affects Vpu function through a phosphorylation-dependent mechanism PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC786

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein antigen binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase regulator activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
RNA splicing NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
ceramide metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
chromosome segregation IDA
Inferred from Direct Assay
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
female meiotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
inactivation of MAPK activity NAS
Non-traceable Author Statement
more info
PubMed 
meiotic sister chromatid cohesion, centromeric IEA
Inferred from Electronic Annotation
more info
 
meiotic spindle elongation IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear envelope reassembly TAS
Traceable Author Statement
more info
 
mitotic sister chromatid separation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of tyrosine phosphorylation of STAT protein NAS
Non-traceable Author Statement
more info
PubMed 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
peptidyl-serine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
protein-containing complex assembly TAS
Traceable Author Statement
more info
PubMed 
regulation of DNA replication NAS
Non-traceable Author Statement
more info
PubMed 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
regulation of Wnt signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of growth NAS
Non-traceable Author Statement
more info
PubMed 
regulation of meiotic cell cycle process involved in oocyte maturation IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
response to organic substance NAS
Non-traceable Author Statement
more info
PubMed 
second-messenger-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
PubMed 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
membrane NAS
Non-traceable Author Statement
more info
PubMed 
microtubule cytoskeleton NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphatase type 2A complex TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Names
medium tumor antigen-associated 61 KDA protein
protein phosphatase 2, regulatory subunit A, alpha
testicular secretory protein Li 1
NP_001350585.1
NP_055040.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047068.1 RefSeqGene

    Range
    5001..41624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363656.2NP_001350585.1  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010320, AK090488, BC026733, CA426613
    Consensus CDS
    CCDS86798.1
    Related
    ENSP00000470504.1, ENST00000462990.5
    Conserved Domains (3) summary
    sd00044
    Location:6690
    HEAT; HEAT repeat [structural motif]
    pfam13646
    Location:309404
    HEAT_2; HEAT repeats
    cl26104
    Location:8283
    HEAT_2; HEAT repeats
  2. NM_014225.6NP_055040.2  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform 1

    See identical proteins and their annotated locations for NP_055040.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    AC010320, BC026733, CA426613
    Consensus CDS
    CCDS12849.1
    UniProtKB/Swiss-Prot
    P30153
    UniProtKB/TrEMBL
    A8K7B7
    Related
    ENSP00000324804.6, ENST00000322088.11
    Conserved Domains (2) summary
    COG1413
    Location:187462
    HEAT; HEAT repeat [General function prediction only]
    sd00044
    Location:245269
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_033500.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC010320, AK293493, BC026733, CA426613

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52190052..52229518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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