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LSM8 LSM8 homolog, U6 small nuclear RNA associated [ Homo sapiens (human) ]

Gene ID: 51691, updated on 23-Nov-2021

Summary

Official Symbol
LSM8provided by HGNC
Official Full Name
LSM8 homolog, U6 small nuclear RNA associatedprovided by HGNC
Primary source
HGNC:HGNC:20471
See related
Ensembl:ENSG00000128534 MIM:607288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NAA38
Summary
This gene encodes a member of the like-Sm family of proteins. The encoded protein consists of a closed barrel shape, made up of five anti-parallel beta strands and an alpha helix. This protein partners with six paralogs to form a heteroheptameric ring which transiently binds U6 small nuclear RNAs and is involved in the general maturation of RNA in the nucleus. [provided by RefSeq, Jan 2010]
Annotation information
Note: The name of this locus was changed from NAA38 to LSM8 by the HUGO Gene Nomenclature Committee. [23 Jan 2014]
Expression
Ubiquitous expression in lymph node (RPKM 1.1), spleen (RPKM 0.9) and 25 other tissues See more
Orthologs
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Genomic context

See LSM8 in Genome Data Viewer
Location:
7q31.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (118184164..118204035)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (117824218..117844089)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene greater CFTR locus negative regulatory element NR19 Neighboring gene uncharacterized LOC105375470 Neighboring gene ankyrin repeat domain 7 Neighboring gene uncharacterized LOC102724495

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ANKRD7

Homology

Clone Names

  • FLJ33242

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables U6 snRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Lsm2-8 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
LSM8 homolog, U6 small nuclear RNA associated
Names
LSM8 U6 small nuclear RNA associated
MAK31-like protein
N-alpha-acetyltransferase 38, NatC auxiliary subunit
U6 snRNA-associated Sm-like protein LSm8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016200.5NP_057284.1  LSM8 homolog, U6 small nuclear RNA associated

    See identical proteins and their annotated locations for NP_057284.1

    Status: REVIEWED

    Source sequence(s)
    AC006389, DA478457
    Consensus CDS
    CCDS5775.1
    UniProtKB/Swiss-Prot
    O95777
    UniProtKB/TrEMBL
    A4D0W0
    Related
    ENSP00000249299.2, ENST00000249299.7
    Conserved Domains (1) summary
    cd01727
    Location:392
    LSm8; Like-Sm protein 8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    118184164..118204035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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