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Lsm8 LSM8 homolog, U6 small nuclear RNA associated [ Mus musculus (house mouse) ]

Gene ID: 76522, updated on 30-Apr-2024

Summary

Official Symbol
Lsm8provided by MGI
Official Full Name
LSM8 homolog, U6 small nuclear RNA associatedprovided by MGI
Primary source
MGI:MGI:1923772
See related
Ensembl:ENSMUSG00000044155 AllianceGenome:MGI:1923772
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lsm8; Naa38; 2010003I05Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of Lsm2-8 complex; U2-type precatalytic spliceosome; and spliceosomal snRNP complex. Orthologous to human LSM8 (LSM8 homolog, U6 small nuclear RNA associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 49.8), liver E14 (RPKM 30.7) and 24 other tissues See more
Orthologs
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Genomic context

See Lsm8 in Genome Data Viewer
Location:
6 A2; 6 8.16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (18848634..18854051)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (18848635..18854052)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23648 Neighboring gene STARR-seq mESC enhancer starr_15271 Neighboring gene STARR-seq mESC enhancer starr_15272 Neighboring gene STARR-positive B cell enhancer mm9_chr6:18798382-18798683 Neighboring gene predicted gene 5874 Neighboring gene STARR-seq mESC enhancer starr_15273 Neighboring gene ankyrin repeat domain 7 Neighboring gene STARR-seq mESC enhancer starr_15274 Neighboring gene STARR-seq mESC enhancer starr_15275 Neighboring gene protein disulfide isomerase associated 6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Lsm2-8 complex ISO
Inferred from Sequence Orthology
more info
 
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
 
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U4/U6 x U5 tri-snRNP complex ISO
Inferred from Sequence Orthology
more info
 
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
LSM8 homolog, U6 small nuclear RNA associated
Names
U6 snRNA-associated Sm-like protein LSm8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133939.1NP_598700.1  LSM8 homolog, U6 small nuclear RNA associated

    See identical proteins and their annotated locations for NP_598700.1

    Status: PROVISIONAL

    Source sequence(s)
    BC019458
    Consensus CDS
    CCDS39433.1
    UniProtKB/Swiss-Prot
    Q3TIX3, Q6ZWM4
    Related
    ENSMUSP00000057238.9, ENSMUST00000056398.11
    Conserved Domains (1) summary
    cd01727
    Location:392
    LSm8; Like-Sm protein 8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    18848634..18854051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)