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ZFR zinc finger RNA binding protein [ Homo sapiens (human) ]

Gene ID: 51663, updated on 7-Jun-2020

Summary

Official Symbol
ZFRprovided by HGNC
Official Full Name
zinc finger RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:17277
See related
Ensembl:ENSG00000056097 MIM:615635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFR1; SPG71
Summary
This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential microRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic cancer cells. [provided by RefSeq, Sep 2016]
Expression
Ubiquitous expression in brain (RPKM 34.3), testis (RPKM 25.1) and 25 other tissues See more
Orthologs

Genomic context

See ZFR in Genome Data Viewer
Location:
5p13.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (32354350..32444740, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (32354456..32444844, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1079, pseudogene Neighboring gene myotubularin related protein 12 Neighboring gene RNA, U6 small nuclear 378, pseudogene Neighboring gene microRNA 579 Neighboring gene transmembrane protein 183A pseudogene Neighboring gene SUB1 regulator of transcription

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify zinc finger RNA binding protein (ZFR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify zinc finger RNA binding protein (ZFR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify zinc finger RNA binding protein (ZFR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify zinc finger RNA binding protein (ZFR), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger RNA-binding protein
Names
M-phase phosphoprotein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051591.1 RefSeqGene

    Range
    5022..95412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016107.5NP_057191.2  zinc finger RNA-binding protein

    See identical proteins and their annotated locations for NP_057191.2

    Status: REVIEWED

    Source sequence(s)
    AJ314790, AL137258, BC017879, BC030540, BC051893, DA691446
    Consensus CDS
    CCDS34139.1
    UniProtKB/Swiss-Prot
    Q96KR1
    UniProtKB/TrEMBL
    Q05D65
    Related
    ENSP00000265069.8, ENST00000265069.13
    Conserved Domains (4) summary
    smart00572
    Location:7841038
    DZF; domain in DSRM or ZnF_C2H2 domain containing proteins
    smart00451
    Location:581612
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:584606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam05647
    Location:420477
    Epiglycanin_TR; Tandem-repeating region of mucin, epiglycanin-like

RNA

  1. NR_144318.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC008949

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    32354350..32444740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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