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PDE4D phosphodiesterase 4D [ Homo sapiens (human) ]

Gene ID: 5144, updated on 23-Dec-2018

Summary

Official Symbol
PDE4Dprovided by HGNC
Official Full Name
phosphodiesterase 4Dprovided by HGNC
Primary source
HGNC:HGNC:8783
See related
Ensembl:ENSG00000113448 MIM:600129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
Summary
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]
Expression
Broad expression in bone marrow (RPKM 7.8), lung (RPKM 3.1) and 20 other tissues See more
Orthologs

Genomic context

See PDE4D in Genome Data Viewer
Location:
5q11.2-q12.1
Exon count:
36
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (58969038..60524329, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (58264865..59783925, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2108 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene ribosomal protein L5 pseudogene 15 Neighboring gene uncharacterized LOC107986348 Neighboring gene uncharacterized LOC107986347 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4 pseudogene 2 Neighboring gene uncharacterized LOC105378988 Neighboring gene uncharacterized LOC107986350 Neighboring gene microRNA 582 Neighboring gene RNA, U6 small nuclear 806, pseudogene Neighboring gene ribosomal protein L31 pseudogene 8 Neighboring gene SET pseudogene 21 Neighboring gene prostate androgen-regulated transcript 1 Neighboring gene DEP domain containing 1B Neighboring gene calcium binding protein 39 pseudogene 1 Neighboring gene keratin 8 pseudogene 31

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Acrodysostosis 2, with or without hormone resistance
MedGen: C3553250 OMIM: 614613 GeneReviews: Not available
Compare labs
Stroke 1
MedGen: C1847482 OMIM: 606799 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2018-02-02)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2018-02-02)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
A whole genome association study of neuroticism using DNA pooling.
NHGRI GWA Catalog
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
NHGRI GWA Catalog
Genome-wide association of sleep and circadian phenotypes.
NHGRI GWA Catalog
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
NHGRI GWA Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
NHGRI GWA Catalog
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.
NHGRI GWA Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Cyclic AMP phosphodiesterase inhibitors AV411 and AV1013 inhibit HIV-1 replication and block HIV-1 Tat-induced neurotoxicity in human microglia, suggesting that cyclic AMP phosphodiesterase is involved in the Tat-mediated neurotoxicity PubMed
tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • DARPP-32 events, organism-specific biosystem (from REACTOME)
    DARPP-32 events, organism-specific biosystemDopamine- and cAMP-regulated phosphoprotein, Mr 32 kDa (DARPP-32), was identified as a major target for dopamine and protein kinase A (PKA) in striatum. Recent advances now indicate that regulation D...
  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystem (from WikiPathways)
    Human Thyroid Stimulating Hormone (TSH) signaling pathway, organism-specific biosystemHuman thyroid stimulating hormone (TSH) is a glycoprotein hormone secreted from the anterior pituitary lobe, which plays an important physiological role in regulation of the hypothalamus-pituitary-th...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Opioid Signalling, organism-specific biosystem (from REACTOME)
    Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ97311, DKFZp686M11213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity TAS
Traceable Author Statement
more info
 
3',5'-cyclic-nucleotide phosphodiesterase activity NAS
Non-traceable Author Statement
more info
PubMed 
ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-2 adrenergic receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cAMP binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ion channel binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion channel binding IPI
Inferred from Physical Interaction
more info
PubMed 
ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate IC
Inferred by Curator
more info
 
adrenergic receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
aging IEA
Inferred from Electronic Annotation
more info
 
cAMP catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
cAMP-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to epinephrine stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
establishment of endothelial barrier ISS
Inferred from Sequence or Structural Similarity
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of relaxation of cardiac muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-5 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cardiac muscle cell contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cardiac muscle cell contraction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of cell communication by electrical coupling involved in cardiac conduction IC
Inferred by Curator
more info
PubMed 
regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of ryanodine-sensitive calcium-release channel activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
regulation of signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Names
cAMP-specific phosphodiesterase PDE4D6
phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
testicular tissue protein Li 136
NP_001098101.1
NP_001159371.1
NP_001184147.1
NP_001184148.1
NP_001184149.1
NP_001184150.1
NP_001184151.1
NP_001184152.1
NP_001336170.1
NP_001336171.1
NP_001336172.1
NP_006194.2
XP_011541771.1
XP_011541772.1
XP_011541773.1
XP_011541775.1
XP_016865054.1
XP_016865055.1
XP_016865056.1
XP_016865059.1
XP_024301878.1
XP_024301879.1
XP_024301880.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027957.2 RefSeqGene

    Range
    41232..1560292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104631.2NP_001098101.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D4

    See identical proteins and their annotated locations for NP_001098101.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (PDE4D4, also known as isoform 1).
    Source sequence(s)
    AC027322, AC092343, BF197530, L20969
    Consensus CDS
    CCDS47213.1
    UniProtKB/Swiss-Prot
    Q08499
    UniProtKB/TrEMBL
    A0A140VJR0
    Related
    ENSP00000345502.6, ENST00000340635.10
    Conserved Domains (1) summary
    pfam00233
    Location:461702
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_001165899.1NP_001159371.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7

    See identical proteins and their annotated locations for NP_001159371.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D7 (also known as isoform 3) has a shorter and distinct N-terminus, compared to isoform PDE4D4. Variants 3 and 13 both encode the same isoform (PDE4D7).
    Source sequence(s)
    AC092343, AY245866, BI492585, DB230503
    Consensus CDS
    CCDS54859.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000423094.2, ENST00000502484.6
    Conserved Domains (1) summary
    pfam00233
    Location:400637
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. NM_001197218.1NP_001184147.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D5

    See identical proteins and their annotated locations for NP_001184147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D5 (also known as isoform 4) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF012073, BF197530
    Consensus CDS
    CCDS56373.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000424852.1, ENST00000507116.5
    Conserved Domains (1) summary
    pfam00233
    Location:397634
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. NM_001197219.1NP_001184148.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D8

    See identical proteins and their annotated locations for NP_001184148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D8 (also known as isoform 5) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC008791, AC092343, AF012073, AF536977, BF197530
    Consensus CDS
    CCDS56372.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000384806.2, ENST00000405755.6
    Conserved Domains (1) summary
    pfam00233
    Location:339576
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  5. NM_001197220.1NP_001184149.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D9

    See identical proteins and their annotated locations for NP_001184149.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D9 (also known as isoform 6) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF012073, AY245867, BF197530
    Consensus CDS
    CCDS56371.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000425605.1, ENST00000503258.5
    Conserved Domains (1) summary
    pfam00233
    Location:331568
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  6. NM_001197221.1NP_001184150.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D2

    See identical proteins and their annotated locations for NP_001184150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D2 (also known as isoform 7) is shorter at the N-terminus, compared to isoform PDE4D4. Variants 7 and 17 both encode the same isoform (PDE4D2).
    Source sequence(s)
    AC092343, AF012074, BF197530
    Consensus CDS
    CCDS56370.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000351800.6, ENST00000358923.10
    Conserved Domains (1) summary
    pfam00233
    Location:159396
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  7. NM_001197222.1NP_001184151.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D1

    See identical proteins and their annotated locations for NP_001184151.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D1 (also known as isoform 8) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF012074, BF197530, U50157
    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (1) summary
    pfam00233
    Location:237478
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  8. NM_001197223.1NP_001184152.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D6

    See identical proteins and their annotated locations for NP_001184152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D6 (also known as isoform 9) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, AF536975, BC036319, BF197530
    Consensus CDS
    CCDS56369.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000321739.8, ENST00000317118.12
    Conserved Domains (1) summary
    pfam00233
    Location:170407
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  9. NM_001349241.1NP_001336170.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and coding region, compared to variant 1. Isoform 10 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC091955, AC092343, AY245866, BI492585, DB230503
    Conserved Domains (1) summary
    pfam00233
    Location:390627
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  10. NM_001349242.1NP_001336171.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR and coding region, compared to variant 1. Isoform 11 is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC008791, AC092343, BF197530, L20970, U50159
    Consensus CDS
    CCDS87297.1
    Related
    ENSP00000490821.1, ENST00000636120.1
    Conserved Domains (1) summary
    pfam00233
    Location:351588
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  11. NM_001349243.1NP_001336172.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR and coding region, compared to variant 1. Isoform 12 is shorter and has a distinct N-terminus, compared to isoform PDE4D4. Variants 12 and 18 both encode the same isoform (12).
    Source sequence(s)
    AC091955, AC092343, AY245866, BI492585, DB230503
    Conserved Domains (1) summary
    pfam00233
    Location:205442
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  12. NM_001364599.1NP_001351528.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variant 3, encodes isoform PDE4D7.
    Source sequence(s)
    AC008818, AC008829, AC008934, AC091955, AC092343
    Conserved Domains (1) summary
    pfam00233
    Location:400637
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  13. NM_001364600.1NP_001351529.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC008934, AC091955, AC109486
  14. NM_001364601.1NP_001351530.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC027322
  15. NM_001364602.1NP_001351531.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 16

    Status: REVIEWED

    Source sequence(s)
    AC008829, AC027322, BC008390
  16. NM_001364603.1NP_001351532.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variant 7, encodes isoform PDE4D2.
    Source sequence(s)
    AC027322, AC092343, AJ250854
    Conserved Domains (1) summary
    pfam00233
    Location:159396
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  17. NM_001364604.1NP_001351533.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variant 12, encodes isoform 12.
    Source sequence(s)
    AC008829, AC092343, AC117527
    Conserved Domains (1) summary
    pfam00233
    Location:205442
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  18. NM_006203.4NP_006194.2  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform PDE4D3

    See identical proteins and their annotated locations for NP_006194.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, compared to variant 1. Isoform PDE4D3 (also known as isoform 2) is shorter and has a distinct N-terminus, compared to isoform PDE4D4.
    Source sequence(s)
    AC092343, BF197530, L20970, U50159
    Consensus CDS
    CCDS54858.1
    UniProtKB/Swiss-Prot
    Q08499
    Related
    ENSP00000353152.5, ENST00000360047.9
    Conserved Domains (1) summary
    pfam00233
    Location:325562
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    58969038..60524329 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446112.1XP_024301880.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:400637
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. XM_024446110.1XP_024301878.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:449686
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. XM_024446111.1XP_024301879.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:400637
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. XM_017009566.1XP_016865055.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (1) summary
    pfam00233
    Location:400637
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  5. XM_011543473.1XP_011541775.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    See identical proteins and their annotated locations for XP_011541775.1

    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (1) summary
    pfam00233
    Location:400637
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  6. XM_017009565.1XP_016865054.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:449686
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  7. XM_011543469.1XP_011541771.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

    See identical proteins and their annotated locations for XP_011541771.1

    Conserved Domains (1) summary
    pfam00233
    Location:449686
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  8. XM_011543471.2XP_011541773.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    See identical proteins and their annotated locations for XP_011541773.1

    UniProtKB/Swiss-Prot
    Q08499
    Conserved Domains (1) summary
    pfam00233
    Location:400637
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  9. XM_011543470.2XP_011541772.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

    See identical proteins and their annotated locations for XP_011541772.1

    Conserved Domains (1) summary
    pfam00233
    Location:449686
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  10. XM_017009567.1XP_016865056.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3

  11. XM_017009570.2XP_016865059.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X4

    Conserved Domains (1) summary
    pfam00233
    Location:205442
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
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