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Pde4d phosphodiesterase 4D, cAMP specific [ Mus musculus (house mouse) ]

Gene ID: 238871, updated on 5-Jan-2023

Summary

Official Symbol
Pde4dprovided by MGI
Official Full Name
phosphodiesterase 4D, cAMP specificprovided by MGI
Primary source
MGI:MGI:99555
See related
Ensembl:ENSMUSG00000021699 AllianceGenome:MGI:99555
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dpde3; 9630011N22Rik
Summary
Enables 3',5'-cyclic-AMP phosphodiesterase activity; ATPase binding activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of heart contraction; and regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and smooth muscle contraction. Located in centrosome. Part of potassium channel complex and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 2.7), thymus adult (RPKM 2.4) and 28 other tissues See more
Orthologs
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Genomic context

See Pde4d in Genome Data Viewer
Location:
13 D2.1; 13 59.69 cM
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (108790711..110092503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (108654177..109955969)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32450 Neighboring gene predicted gene, 27572 Neighboring gene ribosomal protein S3A3 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 52083 Neighboring gene predicted gene, 18923 Neighboring gene microRNA 582 Neighboring gene predicted gene, 32703 Neighboring gene microRNA 1904 Neighboring gene predicted gene, 32881 Neighboring gene RAB3C, member RAS oncogene family Neighboring gene predicted gene, 53813

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-2 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables heterocyclic compound binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in cellular response to epinephrine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to epinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of relaxation of cardiac muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-5 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle cell contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cardiac muscle cell contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle cell contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction IC
Inferred by Curator
more info
PubMed 
involved_in regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ryanodine-sensitive calcium-release channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of potassium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of potassium channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Names
cAMP-specific phosphodiesterase 4D
cyclic AMP specific phosphodiesterase PDE4D5A
dunce
NP_035186.1
XP_006517706.1
XP_006517707.1
XP_006517708.1
XP_006517710.1
XP_006517711.1
XP_006517712.1
XP_030103122.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001402883.1NP_001389812.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC102805, AC161585, AC163650
    UniProtKB/TrEMBL
    E9PVU7
  2. NM_001402884.1NP_001389813.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154756, AC161585, AC163650
  3. NM_001402885.1NP_001389814.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC161585, AC163650, CT033775
    UniProtKB/TrEMBL
    A0A8C6HAA3, B2KF84
  4. NM_001402886.1NP_001389815.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC161585, AC163650
    UniProtKB/TrEMBL
    A0A8C6HAS6
  5. NM_001402887.1NP_001389816.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC163650
    UniProtKB/TrEMBL
    A6XDA7
  6. NM_001402888.1NP_001389817.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC163650
    UniProtKB/TrEMBL
    A0A8C6HBQ7, A6XDB0
  7. NM_011056.3NP_035186.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform 1

    See identical proteins and their annotated locations for NP_035186.1

    Status: VALIDATED

    Source sequence(s)
    AC156571, AC161585, AC163650, AC174458, CT025614
    Consensus CDS
    CCDS49359.1
    UniProtKB/Swiss-Prot
    Q01063, Q8CG05
    UniProtKB/TrEMBL
    A0A8C6HC84, A2RSH1
    Related
    ENSMUSP00000113488.2, ENSMUST00000122041.8
    Conserved Domains (1) summary
    pfam00233
    Location:400641
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    108790711..110092503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517643.2XP_006517706.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1

    UniProtKB/TrEMBL
    E9PVU7
    Related
    ENSMUSP00000112991.2, ENSMUST00000120671.8
    Conserved Domains (2) summary
    pfam00233
    Location:456697
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:218334
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  2. XM_006517644.3XP_006517707.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2

    Related
    ENSMUSP00000121592.2, ENSMUST00000153234.8
    Conserved Domains (2) summary
    pfam00233
    Location:398639
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:160276
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  3. XM_006517645.5XP_006517708.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X3

    UniProtKB/TrEMBL
    B2KF84
    Related
    ENSMUSP00000114089.2, ENSMUST00000119507.8
    Conserved Domains (2) summary
    pfam00233
    Location:356597
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:118234
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  4. XM_030247262.2XP_030103122.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X4

    Related
    ENSMUSP00000119583.2, ENSMUST00000135275.8
    Conserved Domains (2) summary
    pfam00233
    Location:339580
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:101217
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  5. XM_006517647.4XP_006517710.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X5

    UniProtKB/Swiss-Prot
    Q01063
    Related
    ENSMUSP00000073742.6, ENSMUST00000074103.12
    Conserved Domains (2) summary
    pfam00233
    Location:331572
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:93209
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  6. XM_006517649.5XP_006517712.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X7

    UniProtKB/TrEMBL
    A6XDA7
    Related
    ENSMUSP00000113024.2, ENSMUST00000120664.8
    Conserved Domains (2) summary
    pfam00233
    Location:159400
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:137
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)
  7. XM_006517648.5XP_006517711.1  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X6

    UniProtKB/TrEMBL
    A6XDB0
    Related
    ENSMUSP00000113610.2, ENSMUST00000117420.8
    Conserved Domains (2) summary
    pfam00233
    Location:170411
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam18100
    Location:1648
    PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177252.2: Suppressed sequence

    Description
    NM_177252.2: This RefSeq was removed by NCBI staff.