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AMOTL2 angiomotin like 2 [ Homo sapiens (human) ]

Gene ID: 51421, updated on 3-May-2020

Summary

Official Symbol
AMOTL2provided by HGNC
Official Full Name
angiomotin like 2provided by HGNC
Primary source
HGNC:HGNC:17812
See related
Ensembl:ENSG00000114019 MIM:614658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LCCP
Summary
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in fat (RPKM 33.7), placenta (RPKM 20.8) and 24 other tissues See more
Orthologs

Genomic context

See AMOTL2 in Genome Data Viewer
Location:
3q22.2
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (134355345..134375417, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (134074187..134094321, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374118 Neighboring gene ribosomal protein L39 pseudogene 5 Neighboring gene microRNA 6827 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene Neighboring gene high mobility group box 3 pseudogene 13 Neighboring gene microRNA 4788

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Knockdown of Angiomotin (AMOT) by siRNA inhibits HIV-1 release and infectivity, but expression of AMOT-like protein 1 and AMOT-like protein 2 can rescue HIV-1 Gag release PubMed
gag Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of cell polarity involved in ameboidal cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
angiomotin-like protein 2
Names
Leman coiled-coil protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278683.1NP_001265612.1  angiomotin-like protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest protein.
    Source sequence(s)
    AF175966, AI214560, AK299270, AW294642, BC011454
    Consensus CDS
    CCDS63784.1
    UniProtKB/Swiss-Prot
    Q9Y2J4
    Related
    ENSP00000424765.1, ENST00000514516.5
    Conserved Domains (2) summary
    pfam06156
    Location:370422
    DUF972; Protein of unknown function (DUF972)
    pfam12240
    Location:540741
    Angiomotin_C; Angiomotin C terminal
  2. NM_001278685.2NP_001265614.1  angiomotin-like protein 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus and lacks two internal amino acids compared to isoform 1.
    Source sequence(s)
    AF175966, AI214560, AK223598, AK299270, AW294642, BC011454, DA330301
    Consensus CDS
    CCDS63783.1
    UniProtKB/Swiss-Prot
    Q9Y2J4
    Related
    ENSP00000425475.1, ENST00000513145.1
    Conserved Domains (2) summary
    pfam06156
    Location:312364
    DUF972; Protein of unknown function (DUF972)
    pfam12240
    Location:482681
    Angiomotin_C; Angiomotin C terminal
  3. NM_001363943.2NP_001350872.1  angiomotin-like protein 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC010207
    Consensus CDS
    CCDS87138.1
    Conserved Domains (2) summary
    pfam12240
    Location:482683
    Angiomotin_C; Angiomotin C terminal
    cl25732
    Location:298581
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_016201.4NP_057285.3  angiomotin-like protein 2 isoform 2

    See identical proteins and their annotated locations for NP_057285.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, uses an alternate in-frame splice site in the 3' coding region and initiates translation at a downstream start site, compared to variant 1. It encodes isoform 2, which is shorter at the N-terminus and contains an additional internal amino acid compared to isoform 1.
    Source sequence(s)
    AF175966, AI214560, AK291616, AW294642, BC011454, DA330301
    Consensus CDS
    CCDS33860.1
    UniProtKB/Swiss-Prot
    Q9Y2J4
    Related
    ENSP00000249883.5, ENST00000249883.9
    Conserved Domains (2) summary
    pfam06156
    Location:312364
    DUF972; Protein of unknown function (DUF972)
    pfam12240
    Location:482683
    Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    134355345..134375417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006580.1XP_016862069.1  angiomotin-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2J4
    Conserved Domains (2) summary
    pfam06156
    Location:312364
    DUF972; Protein of unknown function (DUF972)
    pfam12240
    Location:482683
    Angiomotin_C; Angiomotin C terminal
  2. XM_006713654.3XP_006713717.1  angiomotin-like protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006713717.1

    UniProtKB/Swiss-Prot
    Q9Y2J4
    Related
    ENSP00000409999.2, ENST00000422605.6
    Conserved Domains (2) summary
    pfam12240
    Location:482683
    Angiomotin_C; Angiomotin C terminal
    cl25732
    Location:298581
    SMC_N; RecF/RecN/SMC N terminal domain
  3. XM_017006581.1XP_016862070.1  angiomotin-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2J4
    Conserved Domains (2) summary
    pfam06156
    Location:312364
    DUF972; Protein of unknown function (DUF972)
    pfam12240
    Location:482683
    Angiomotin_C; Angiomotin C terminal
  4. XM_017006582.1XP_016862071.1  angiomotin-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9Y2J4
    Conserved Domains (2) summary
    pfam06156
    Location:312364
    DUF972; Protein of unknown function (DUF972)
    pfam12240
    Location:482683
    Angiomotin_C; Angiomotin C terminal
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