U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Amotl2 angiomotin-like 2 [ Mus musculus (house mouse) ]

Gene ID: 56332, updated on 26-Sep-2022

Summary

Official Symbol
Amotl2provided by MGI
Official Full Name
angiomotin-like 2provided by MGI
Primary source
MGI:MGI:1929286
See related
Ensembl:ENSMUSG00000032531 AllianceGenome:MGI:1929286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lccp; MASCOT; mKIAA0989
Summary
Enables identical protein binding activity. Predicted to be involved in several processes, including angiogenesis; establishment of cell polarity involved in ameboidal cell migration; and hippo signaling. Predicted to act upstream of or within Wnt signaling pathway. Located in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including axial skeleton; brain ventricular layer; dorsal aorta; and telencephalon. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 51.4), lung adult (RPKM 30.8) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Amotl2 in Genome Data Viewer
Location:
9; 9 F1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (102594290..102610616)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (102717091..102733418)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm1302 Neighboring gene predicted gene, 46150 Neighboring gene predicted gene 5627 Neighboring gene predicted gene, 46151

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in angiogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in establishment of cell polarity involved in ameboidal cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
angiomotin-like protein 2
Names
Leman coiled-coil protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019764.2NP_062738.2  angiomotin-like protein 2

    See identical proteins and their annotated locations for NP_062738.2

    Status: VALIDATED

    Source sequence(s)
    AK141348, BB726257
    Consensus CDS
    CCDS40745.1
    UniProtKB/Swiss-Prot
    Q8K371, Q9QUS0
    Related
    ENSMUSP00000035121.8, ENSMUST00000035121.14
    Conserved Domains (2) summary
    COG1196
    Location:301578
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:478679
    Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    102594290..102610616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511772.4XP_006511835.1  angiomotin-like protein 2 isoform X2

    Conserved Domains (2) summary
    COG1196
    Location:324601
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:501702
    Angiomotin_C; Angiomotin C terminal
  2. XM_006511771.4XP_006511834.2  angiomotin-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511834.2

    UniProtKB/Swiss-Prot
    Q8K371, Q9QUS0
    Conserved Domains (2) summary
    COG1196
    Location:301578
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:478679
    Angiomotin_C; Angiomotin C terminal
  3. XM_006511773.4XP_006511836.1  angiomotin-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006511836.1

    UniProtKB/Swiss-Prot
    Q8K371, Q9QUS0
    Conserved Domains (2) summary
    COG1196
    Location:301578
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:478679
    Angiomotin_C; Angiomotin C terminal