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POP5 POP5 homolog, ribonuclease P/MRP subunit [ Homo sapiens (human) ]

Gene ID: 51367, updated on 23-Nov-2021

Summary

Official Symbol
POP5provided by HGNC
Official Full Name
POP5 homolog, ribonuclease P/MRP subunitprovided by HGNC
Primary source
HGNC:HGNC:17689
See related
Ensembl:ENSG00000167272 MIM:609992
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RPP2; RPP20; hPop5; HSPC004
Expression
Ubiquitous expression in adrenal (RPKM 15.3), fat (RPKM 13.2) and 25 other tissues See more
Orthologs
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Genomic context

See POP5 in Genome Data Viewer
Location:
12q24.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (120578764..120581452, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121016567..121019205, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene coenzyme Q5, methyltransferase Neighboring gene ribosomal protein L29 pseudogene 24 Neighboring gene ring finger protein 10 Neighboring gene ribosomal protein L11 pseudogene 5 Neighboring gene CABP1 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae; POP5) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ribonuclease MRP complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribonuclease P/MRP protein subunit POP5
Names
processing of precursor 5, ribonuclease P/MRP subunit
NP_057002.2
NP_937845.1
XP_011536743.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015918.4NP_057002.2  ribonuclease P/MRP protein subunit POP5 isoform a

    See identical proteins and their annotated locations for NP_057002.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform a).
    Source sequence(s)
    AC063943, AJ306296, BI668578
    Consensus CDS
    CCDS9202.1
    UniProtKB/Swiss-Prot
    Q969H6
    Related
    ENSP00000350098.4, ENST00000357500.5
    Conserved Domains (1) summary
    pfam01900
    Location:7115
    RNase_P_Rpp14; Rpp14/Pop5 family
  2. NM_198202.2NP_937845.1  ribonuclease P/MRP protein subunit POP5 isoform c

    See identical proteins and their annotated locations for NP_937845.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform c) that has a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AC063943, AF070660, BI549018, BU155588
    Consensus CDS
    CCDS9203.1
    UniProtKB/Swiss-Prot
    Q969H6
    Related
    ENSP00000341791.2, ENST00000341039.6
    Conserved Domains (1) summary
    pfam01900
    Location:753
    RNase_P_Rpp14; Rpp14/Pop5 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    120578764..120581452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538441.1XP_011536743.1  ribonuclease P/MRP protein subunit POP5 isoform X1

    Conserved Domains (1) summary
    pfam01900
    Location:7133
    RNase_P_Rpp14; Rpp14/Pop5 family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198201.1: Suppressed sequence

    Description
    NM_198201.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein and it is a nonsense-mediated mRNA decay (NMD) candidate.
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