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Pop5 processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 117109, updated on 18-Sep-2024

Summary

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Official Symbol
Pop5provided by MGI
Official Full Name
processing of precursor 5, ribonuclease P/MRP family (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:2151221
See related
Ensembl:ENSMUSG00000060152 AllianceGenome:MGI:2151221
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnasep3; 1500019J17Rik; 2700077E03Rik
Summary
Enables ribonuclease P activity. Acts upstream of or within tRNA processing. Part of nucleolar ribonuclease P complex. Is expressed in Meckel's cartilage and skeleton. Orthologous to human POP5 (POP5 homolog, ribonuclease P/MRP subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 61.9), kidney adult (RPKM 33.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 F; 5 56.01 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (115373505..115379031)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (115235588..115240972)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1058 Neighboring gene malectin Neighboring gene STARR-seq mESC enhancer starr_14105 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:115617496-115617679 Neighboring gene calcium binding protein 1 Neighboring gene STARR-seq mESC enhancer starr_14108 Neighboring gene STARR-seq mESC enhancer starr_14109 Neighboring gene predicted gene, 35515 Neighboring gene STARR-seq mESC enhancer starr_14111 Neighboring gene STARR-positive B cell enhancer ABC_E8072 Neighboring gene ring finger protein 10 Neighboring gene STARR-seq mESC enhancer starr_14112 Neighboring gene STARR-positive B cell enhancer ABC_E3605 Neighboring gene STARR-seq mESC enhancer starr_14114 Neighboring gene coenzyme Q5 methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Xiao S, et al. Annu Rev Biochem, 2002. PMID 12045094, Free PMC Article
  2. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
  3. hPop5, a protein subunit of the human RNase MRP and RNase P endoribonucleases. van Eenennaam H, et al. J Biol Chem, 2001 Aug 24. PMID 11413139
  4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribonuclease MRP activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables ribonuclease P RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables ribonuclease P RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribonuclease P activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within rRNA processing ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA 5'-leader removal ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within tRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of nucleolar ribonuclease P complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex ISA
Inferred from Sequence Alignment
more info
 PubMed 
part_of ribonuclease MRP complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribonuclease P/MRP protein subunit POP5
NP_001390591.1
NP_080674.1
XP_030109934.1
XP_036020636.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403662.1 → NP_001390591.1  ribonuclease P/MRP protein subunit POP5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC145070

  2. NM_026398.5 → NP_080674.1  ribonuclease P/MRP protein subunit POP5 isoform 1

    See identical proteins and their annotated locations for NP_080674.1

    Status: VALIDATED

    Source sequence(s)
    AC145070
    Consensus CDS
    CCDS19583.1
    UniProtKB/Swiss-Prot
    Q9CSC3, Q9CSL4, Q9DB28
    Related
    ENSMUSP00000080215.7, ENSMUST00000081497.13
    Conserved Domains (1) summary
    pfam01900
    Location:7 → 115
    RNase_P_Rpp14; Rpp14/Pop5 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    115373505..115379031
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164743.1 → XP_036020636.1  ribonuclease P/MRP protein subunit POP5 isoform X1

    UniProtKB/Swiss-Prot
    Q9CSC3, Q9CSL4, Q9DB28
    Conserved Domains (1) summary
    pfam01900
    Location:7 → 115
    RNase_P_Rpp14; Rpp14/Pop5 family

  2. XM_030254074.2 → XP_030109934.1  ribonuclease P/MRP protein subunit POP5 isoform X1

    UniProtKB/Swiss-Prot
    Q9CSC3, Q9CSL4, Q9DB28
    Related
    ENSMUSP00000118408.2, ENSMUST00000135455.2
    Conserved Domains (1) summary
    pfam01900
    Location:7 → 115
    RNase_P_Rpp14; Rpp14/Pop5 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB28.1 GenPept UniProtKB/Swiss-Prot:Q9DB28

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