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KRT76 keratin 76 [ Homo sapiens (human) ]

Gene ID: 51350, updated on 7-Jun-2020

Summary

Official Symbol
KRT76provided by HGNC
Official Full Name
keratin 76provided by HGNC
Primary source
HGNC:HGNC:24430
See related
Ensembl:ENSG00000185069 MIM:616671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KRT2B; KRT2P; HUMCYT2A
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq, Jun 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KRT76 in Genome Data Viewer
Location:
12q13.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52768155..52777345, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53161939..53171129, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 127 pseudogene Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 2 Neighboring gene keratin 3 Neighboring gene keratin 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
keratinization TAS
Traceable Author Statement
more info
 
pigmentation IEA
Inferred from Electronic Annotation
more info
 
sebaceous gland development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
keratin filament IEA
Inferred from Electronic Annotation
more info
 
nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type II cytoskeletal 2 oral
Names
CK-2P
K2P
K76
cytokeratin 2
cytokeratin-2P
keratin 2p
keratin 76, type II
type-II keratin Kb9

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012420.1 RefSeqGene

    Range
    5001..14191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015848.4NP_056932.2  keratin, type II cytoskeletal 2 oral

    See identical proteins and their annotated locations for NP_056932.2

    Status: REVIEWED

    Source sequence(s)
    AK299390, M99063
    Consensus CDS
    CCDS8838.1
    UniProtKB/Swiss-Prot
    Q01546
    Related
    ENSP00000330101.2, ENST00000332411.2
    Conserved Domains (3) summary
    pfam00038
    Location:182495
    Filament; Intermediate filament protein
    pfam16208
    Location:16179
    Keratin_2_head; Keratin type II head
    cl23720
    Location:408469
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52768155..52777345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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