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KLF3 Kruppel like factor 3 [ Homo sapiens (human) ]

Gene ID: 51274, updated on 23-Nov-2021

Summary

Official Symbol
KLF3provided by HGNC
Official Full Name
Kruppel like factor 3provided by HGNC
Primary source
HGNC:HGNC:16516
See related
Ensembl:ENSG00000109787 MIM:609392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BKLF
Expression
Ubiquitous expression in colon (RPKM 22.1), gall bladder (RPKM 19.2) and 25 other tissues See more
Orthologs
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Genomic context

See KLF3 in Genome Data Viewer
Location:
4p14
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (38664079..38701517)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38665820..38703138)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986224 Neighboring gene long intergenic non-protein coding RNA 2278 Neighboring gene KLF3 antisense RNA 1 Neighboring gene uncharacterized LOC105374413 Neighboring gene uncharacterized LOC105374412

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
GeneReviews: Not available
Identification of genetic loci associated with Helicobacter pylori serologic status.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC48279

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
Krueppel-like factor 3
Names
CACCC-box-binding protein BKLF
Kruppel-like factor 3 (basic)
TEF-2
basic Kruppel-like factor
basic krueppel-like factor
basic kruppel like factor
transcript ch138

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016531.6NP_057615.3  Krueppel-like factor 3

    See identical proteins and their annotated locations for NP_057615.3

    Status: VALIDATED

    Source sequence(s)
    AC021860, AF285837, BU689914, DB246277
    Consensus CDS
    CCDS3444.1
    UniProtKB/Swiss-Prot
    P57682
    UniProtKB/TrEMBL
    A0A024R9T8
    Related
    ENSP00000261438.5, ENST00000261438.10
    Conserved Domains (4) summary
    sd00017
    Location:262284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:260284
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:306331
    zf-H2C2_2; Zinc-finger double domain
    cd21577
    Location:49260
    KLF3_N; N-terminal domain of Kruppel-like factor 3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    38664079..38701517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008279.2XP_016863768.1  Krueppel-like factor 3 isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:233315
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:237259
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:281306
    zf-H2C2_2; Zinc-finger double domain
    cd21577
    Location:24235
    KLF3_N; N-terminal domain of Kruppel-like factor 3

RNA

  1. XR_925142.1 RNA Sequence

  2. XR_001741235.2 RNA Sequence

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