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KLF3 Kruppel like factor 3 [ Homo sapiens (human) ]

Gene ID: 51274, updated on 9-Dec-2018

Summary

Official Symbol
KLF3provided by HGNC
Official Full Name
Kruppel like factor 3provided by HGNC
Primary source
HGNC:HGNC:16516
See related
Ensembl:ENSG00000109787 MIM:609392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BKLF
Expression
Ubiquitous expression in colon (RPKM 22.1), gall bladder (RPKM 19.2) and 25 other tissues See more
Orthologs

Genomic context

See KLF3 in Genome Data Viewer
Location:
4p14
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (38664079..38701508)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (38665790..38703129)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2278 Neighboring gene uncharacterized LOC102723415 Neighboring gene KLF3 antisense RNA 1 Neighboring gene uncharacterized LOC105374413 Neighboring gene uncharacterized LOC105374412

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
NHGRI GWA Catalog
Identification of genetic loci associated with Helicobacter pylori serologic status.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC48279

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to peptide IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Krueppel-like factor 3
Names
CACCC-box-binding protein BKLF
Kruppel-like factor 3 (basic)
TEF-2
basic Kruppel-like factor
basic krueppel-like factor
basic kruppel like factor
transcript ch138

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016531.6NP_057615.3  Krueppel-like factor 3

    See identical proteins and their annotated locations for NP_057615.3

    Status: VALIDATED

    Source sequence(s)
    AC021860, AF285837, BU689914, DB246277
    Consensus CDS
    CCDS3444.1
    UniProtKB/Swiss-Prot
    P57682
    UniProtKB/TrEMBL
    A0A024R9T8
    Related
    ENSP00000261438.5, ENST00000261438.9
    Conserved Domains (3) summary
    COG5048
    Location:70332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:262284
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:306331
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    38664079..38701508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008279.2XP_016863768.1  Krueppel-like factor 3 isoform X1

    Conserved Domains (3) summary
    COG5048
    Location:45307
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:237259
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:281306
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_925142.1 RNA Sequence

  2. XR_001741235.2 RNA Sequence

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