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Klf3 Kruppel-like factor 3 (basic) [ Mus musculus (house mouse) ]

Gene ID: 16599, updated on 26-Sep-2022

Summary

Official Symbol
Klf3provided by MGI
Official Full Name
Kruppel-like factor 3 (basic)provided by MGI
Primary source
MGI:MGI:1342773
See related
Ensembl:ENSMUSG00000029178 AllianceGenome:MGI:1342773
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bklf; Tef-2; 9930027G08Rik
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and integumental system. Orthologous to human KLF3 (Kruppel like factor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 33.8), thymus adult (RPKM 20.9) and 27 other tissues See more
Orthologs
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Genomic context

See Klf3 in Genome Data Viewer
Location:
5; 5 C3.1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (64960864..64990246)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (64803521..64832901)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105244755 Neighboring gene predicted gene, 54286 Neighboring gene predicted gene, 31684 Neighboring gene U7 small nuclear RNA Neighboring gene VISTA enhancer mm1725

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC151315

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Krueppel-like factor 3
Names
CACCC-box-binding protein BKLF
basic krueppel-like factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008453.6NP_032479.1  Krueppel-like factor 3

    See identical proteins and their annotated locations for NP_032479.1

    Status: VALIDATED

    Source sequence(s)
    AC130535
    Consensus CDS
    CCDS19301.1
    UniProtKB/Swiss-Prot
    Q60980
    UniProtKB/TrEMBL
    A0A8C6GV60, Q545J5
    Related
    ENSMUSP00000129363.2, ENSMUST00000165536.8
    Conserved Domains (4) summary
    sd00017
    Location:261283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:259283
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:305330
    zf-H2C2_2; Zinc-finger double domain
    cd21577
    Location:49259
    KLF3_N; N-terminal domain of Kruppel-like factor 3

RNA

  1. NR_165035.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC130535

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    64960864..64990246
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503751.5XP_006503814.1  Krueppel-like factor 3 isoform X1

    See identical proteins and their annotated locations for XP_006503814.1

    UniProtKB/Swiss-Prot
    Q60980
    UniProtKB/TrEMBL
    A0A8C6GV60, Q545J5
    Related
    ENSMUSP00000128429.2, ENSMUST00000166409.6
    Conserved Domains (4) summary
    sd00017
    Location:261283
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:259283
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:305330
    zf-H2C2_2; Zinc-finger double domain
    cd21577
    Location:49259
    KLF3_N; N-terminal domain of Kruppel-like factor 3