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CDK16 cyclin dependent kinase 16 [ Homo sapiens (human) ]

Gene ID: 5127, updated on 14-Oct-2018

Summary

Official Symbol
CDK16provided by HGNC
Official Full Name
cyclin dependent kinase 16provided by HGNC
Primary source
HGNC:HGNC:8749
See related
Ensembl:ENSG00000102225 MIM:311550; Vega:OTTHUMG00000021438
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE
Summary
The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]
Expression
Ubiquitous expression in heart (RPKM 14.6), brain (RPKM 14.2) and 25 other tissues See more
Orthologs

Genomic context

See CDK16 in Genome Data Viewer
Location:
Xp11.3
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (47217881..47229997)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47077445..47089396)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene inositol 1,3,4-triphosphate 5/6 kinase pseudogene Neighboring gene RNA binding motif protein 10 Neighboring gene uncharacterized LOC105373194 Neighboring gene ubiquitin like modifier activating enzyme 1 Neighboring gene inactivation escape 1 Neighboring gene ubiquitin specific peptidase 11 Neighboring gene nicolin 2, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cyclin-dependent kinase 16 (CDK16; PCTAIRE) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16665

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
growth hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extrinsic component of cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
colocalizes_with synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cyclin-dependent kinase 16
Names
PCTAIRE-motif protein kinase 1
cell division protein kinase 16
serine/threonine-protein kinase PCTAIRE-1
testis secretory sperm-binding protein Li 224n
NP_001163931.1
NP_006192.1
NP_148978.2
XP_011542222.1
XP_011542223.1
XP_011542224.1
XP_011542225.1
XP_011542226.1
XP_011542227.1
XP_011542228.1
XP_011542229.1
XP_011542230.1
XP_016885058.1
XP_016885059.1
XP_016885060.1
XP_016885061.1
XP_016885062.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012517.1 RefSeqGene

    Range
    5001..16869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170460.1NP_001163931.1  cyclin-dependent kinase 16 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 3, which has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK096881, AK290145, AK301832, BC006190
    Consensus CDS
    CCDS55408.1
    UniProtKB/Swiss-Prot
    Q00536
    UniProtKB/TrEMBL
    Q9BRL4
    Related
    ENSP00000276052.6, ENST00000276052.10
    Conserved Domains (2) summary
    PLN00009
    Location:236524
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:236532
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  2. NM_006201.4NP_006192.1  cyclin-dependent kinase 16 isoform 1

    See identical proteins and their annotated locations for NP_006192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shortest isoform (1).
    Source sequence(s)
    AK096881, AK290145, BC006190, DA816614
    Consensus CDS
    CCDS14276.1
    UniProtKB/Swiss-Prot
    Q00536
    UniProtKB/TrEMBL
    A0A140VK97, Q9BRL4
    Related
    ENSP00000349762.4, OTTHUMP00000023208, ENST00000357227.8, OTTHUMT00000056406
    Conserved Domains (1) summary
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  3. NM_033018.3NP_148978.2  cyclin-dependent kinase 16 isoform 2

    See identical proteins and their annotated locations for NP_148978.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 2, which has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    BC015607, BQ187876, DA900611
    Consensus CDS
    CCDS48101.1
    UniProtKB/Swiss-Prot
    Q00536
    UniProtKB/TrEMBL
    A0A024R183
    Related
    ENSP00000405798.2, OTTHUMP00000023209, ENST00000457458.6, OTTHUMT00000056407
    Conserved Domains (1) summary
    cd07873
    Location:168464
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    47217881..47229997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029573.1XP_016885062.1  cyclin-dependent kinase 16 isoform X7

    UniProtKB/Swiss-Prot
    Q00536
    UniProtKB/TrEMBL
    A0A140VK97
    Conserved Domains (1) summary
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  2. XM_011543928.1XP_011542230.1  cyclin-dependent kinase 16 isoform X6

    See identical proteins and their annotated locations for XP_011542230.1

    Conserved Domains (2) summary
    PLN00009
    Location:162450
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  3. XM_017029569.1XP_016885058.1  cyclin-dependent kinase 16 isoform X3

  4. XM_011543921.1XP_011542223.1  cyclin-dependent kinase 16 isoform X2

    See identical proteins and their annotated locations for XP_011542223.1

    Conserved Domains (2) summary
    PLN00009
    Location:209497
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:209505
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  5. XM_011543922.1XP_011542224.1  cyclin-dependent kinase 16 isoform X4

    Conserved Domains (2) summary
    PLN00009
    Location:205493
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:205501
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  6. XM_011543923.2XP_011542225.1  cyclin-dependent kinase 16 isoform X5

    See identical proteins and their annotated locations for XP_011542225.1

    Conserved Domains (2) summary
    PLN00009
    Location:168456
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:168464
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  7. XM_017029572.2XP_016885061.1  cyclin-dependent kinase 16 isoform X7

    UniProtKB/Swiss-Prot
    Q00536
    UniProtKB/TrEMBL
    A0A140VK97
    Conserved Domains (1) summary
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  8. XM_011543927.3XP_011542229.1  cyclin-dependent kinase 16 isoform X6

    See identical proteins and their annotated locations for XP_011542229.1

    Conserved Domains (2) summary
    PLN00009
    Location:162450
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  9. XM_017029570.2XP_016885059.1  cyclin-dependent kinase 16 isoform X7

    UniProtKB/Swiss-Prot
    Q00536
    UniProtKB/TrEMBL
    A0A140VK97
    Conserved Domains (1) summary
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  10. XM_011543925.3XP_011542227.1  cyclin-dependent kinase 16 isoform X6

    See identical proteins and their annotated locations for XP_011542227.1

    Conserved Domains (2) summary
    PLN00009
    Location:162450
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  11. XM_011543924.2XP_011542226.1  cyclin-dependent kinase 16 isoform X6

    See identical proteins and their annotated locations for XP_011542226.1

    Conserved Domains (2) summary
    PLN00009
    Location:162450
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  12. XM_017029571.1XP_016885060.1  cyclin-dependent kinase 16 isoform X7

    UniProtKB/Swiss-Prot
    Q00536
    UniProtKB/TrEMBL
    A0A140VK97
    Conserved Domains (1) summary
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  13. XM_011543926.1XP_011542228.1  cyclin-dependent kinase 16 isoform X6

    See identical proteins and their annotated locations for XP_011542228.1

    Conserved Domains (2) summary
    PLN00009
    Location:162450
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:162458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase
  14. XM_011543920.3XP_011542222.1  cyclin-dependent kinase 16 isoform X1

    Conserved Domains (2) summary
    PLN00009
    Location:236524
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07873
    Location:236532
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

RNA

  1. XR_949017.3 RNA Sequence

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