Format

Send to:

Choose Destination

COX16 cytochrome c oxidase assembly factor COX16 [ Homo sapiens (human) ]

Gene ID: 51241, updated on 7-Jun-2020

Summary

Official Symbol
COX16provided by HGNC
Official Full Name
cytochrome c oxidase assembly factor COX16provided by HGNC
Primary source
HGNC:HGNC:20213
See related
Ensembl:ENSG00000133983 MIM:618064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
hCOX16; HSPC203; C14orf112
Expression
Ubiquitous expression in colon (RPKM 14.7), adrenal (RPKM 14.7) and 25 other tissues See more
Orthologs

Genomic context

See COX16 in Genome Data Viewer
Location:
14q24.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (70325081..70359683, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70791798..70826448, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase domain 21 pseudogene 1 Neighboring gene uncharacterized LOC101928046 Neighboring gene uncharacterized LOC105370552 Neighboring gene SYNJ2BP-COX16 readthrough Neighboring gene RNA, U2 small nuclear 51, pseudogene Neighboring gene synaptojanin 2 binding protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough SYNJ2BP-COX16

Readthrough gene: SYNJ2BP-COX16, Included gene: SYNJ2BP

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitochondrial respiratory chain complex IV assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial respiratory chain complex IV assembly IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex IV assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase assembly protein COX16 homolog, mitochondrial
Names
COX16, cytochrome c oxidase assembly homolog
cytochrome c oxidase assembly factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204090.2NP_001191019.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_001191019.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AW088547, CB156527, FJ460510
    UniProtKB/TrEMBL
    B8XYC5
    Conserved Domains (1) summary
    pfam14138
    Location:2464
    COX16; Cytochrome c oxidase assembly protein COX16
  2. NM_016468.7NP_057552.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_057552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW088547, FJ460510
    Consensus CDS
    CCDS9802.1
    UniProtKB/Swiss-Prot
    Q9P0S2
    UniProtKB/TrEMBL
    B8XYC5
    Related
    ENSP00000374562.5, ENST00000389912.7
    Conserved Domains (1) summary
    pfam14138
    Location:1888
    COX16; Cytochrome c oxidase assembly protein COX16

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    70325081..70359683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center