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CRIM1 cysteine rich transmembrane BMP regulator 1 [ Homo sapiens (human) ]

Gene ID: 51232, updated on 23-Apr-2019

Summary

Official Symbol
CRIM1provided by HGNC
Official Full Name
cysteine rich transmembrane BMP regulator 1provided by HGNC
Primary source
HGNC:HGNC:2359
See related
Ensembl:ENSG00000150938 MIM:606189
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S52; CRIM-1
Summary
This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]
Expression
Broad expression in placenta (RPKM 93.7), fat (RPKM 55.7) and 23 other tissues See more
Orthologs

Genomic context

See CRIM1 in Genome Data Viewer
Location:
2p22.2
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (36356088..36551135)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (36583370..36778278)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene meiotic recombination hotspot M Neighboring gene CRIM1 divergent transcript Neighboring gene fasciculation and elongation protein zeta 2 Neighboring gene receptor for activated C kinase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
NHGRI GWA Catalog
Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of cysteine rich transmembrane BMP regulator 1 (CRIM1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138194

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
insulin-like growth factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
insulin-like growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cysteine-rich motor neuron 1 protein
Names
cysteine rich transmembrane BMP regulator 1 (chordin-like)
cysteine-rich repeat-containing protein S52

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016441.3NP_057525.1  cysteine-rich motor neuron 1 protein precursor

    See identical proteins and their annotated locations for NP_057525.1

    Status: REVIEWED

    Source sequence(s)
    AB209139, AC009414, AF167706
    Consensus CDS
    CCDS1783.1
    UniProtKB/Swiss-Prot
    Q9NZV1
    Related
    ENSP00000280527.2, ENST00000280527.7
    Conserved Domains (4) summary
    smart00214
    Location:403456
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:3990
    IGFBP; Insulin-like growth factor binding protein
    pfam02822
    Location:567592
    Antistasin; Antistasin family
    cl17735
    Location:683734
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    36356088..36551135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004259.1XP_016859748.1  cysteine-rich motor neuron 1 protein isoform X5

  2. XM_011532899.3XP_011531201.1  cysteine-rich motor neuron 1 protein isoform X1

    Conserved Domains (4) summary
    smart00214
    Location:444497
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:3990
    IGFBP; Insulin-like growth factor binding protein
    pfam02822
    Location:608633
    Antistasin; Antistasin family
    cl17735
    Location:724775
    VWC; von Willebrand factor type C domain
  3. XM_011532901.3XP_011531203.1  cysteine-rich motor neuron 1 protein isoform X2

    Conserved Domains (4) summary
    smart00214
    Location:444497
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:3990
    IGFBP; Insulin-like growth factor binding protein
    pfam02822
    Location:608633
    Antistasin; Antistasin family
    cl17735
    Location:724775
    VWC; von Willebrand factor type C domain
  4. XM_011532898.3XP_011531200.1  cysteine-rich motor neuron 1 protein isoform X7

    Conserved Domains (4) summary
    smart00214
    Location:444497
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:3990
    IGFBP; Insulin-like growth factor binding protein
    pfam02822
    Location:608633
    Antistasin; Antistasin family
    cl17735
    Location:724775
    VWC; von Willebrand factor type C domain
  5. XM_017004258.2XP_016859747.1  cysteine-rich motor neuron 1 protein isoform X3

  6. XM_017004260.2XP_016859749.1  cysteine-rich motor neuron 1 protein isoform X6

  7. XM_005264357.5XP_005264414.1  cysteine-rich motor neuron 1 protein isoform X4

    Conserved Domains (4) summary
    smart00214
    Location:345398
    VWC; von Willebrand factor (vWF) type C domain
    pfam00219
    Location:3990
    IGFBP; Insulin-like growth factor binding protein
    pfam02822
    Location:509534
    Antistasin; Antistasin family
    cl17735
    Location:625676
    VWC; von Willebrand factor type C domain
  8. XM_017004262.1XP_016859751.1  cysteine-rich motor neuron 1 protein isoform X9

  9. XM_017004261.1XP_016859750.1  cysteine-rich motor neuron 1 protein isoform X9

  10. XM_024452945.1XP_024308713.1  cysteine-rich motor neuron 1 protein isoform X8

    Conserved Domains (3) summary
    smart00214
    Location:245298
    VWC; von Willebrand factor (vWF) type C domain
    pfam02822
    Location:409434
    Antistasin; Antistasin family
    cl17735
    Location:525576
    VWC; von Willebrand factor type C domain
  11. XM_024452946.1XP_024308714.1  cysteine-rich motor neuron 1 protein isoform X8

    Conserved Domains (3) summary
    smart00214
    Location:245298
    VWC; von Willebrand factor (vWF) type C domain
    pfam02822
    Location:409434
    Antistasin; Antistasin family
    cl17735
    Location:525576
    VWC; von Willebrand factor type C domain
  12. XM_024452947.1XP_024308715.1  cysteine-rich motor neuron 1 protein isoform X8

    Conserved Domains (3) summary
    smart00214
    Location:245298
    VWC; von Willebrand factor (vWF) type C domain
    pfam02822
    Location:409434
    Antistasin; Antistasin family
    cl17735
    Location:525576
    VWC; von Willebrand factor type C domain
  13. XM_024452948.1XP_024308716.1  cysteine-rich motor neuron 1 protein isoform X8

    Conserved Domains (3) summary
    smart00214
    Location:245298
    VWC; von Willebrand factor (vWF) type C domain
    pfam02822
    Location:409434
    Antistasin; Antistasin family
    cl17735
    Location:525576
    VWC; von Willebrand factor type C domain

RNA

  1. XR_001738763.2 RNA Sequence

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NW_003315908.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    6693..7089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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