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PHF20 PHD finger protein 20 [ Homo sapiens (human) ]

Gene ID: 51230, updated on 11-Sep-2019

Summary

Official Symbol
PHF20provided by HGNC
Official Full Name
PHD finger protein 20provided by HGNC
Primary source
HGNC:HGNC:16098
See related
Ensembl:ENSG00000025293 MIM:610335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NZF; TZP; GLEA2; HCA58; TDRD20A; C20orf104
Expression
Ubiquitous expression in testis (RPKM 8.8), brain (RPKM 8.0) and 25 other tissues See more
Orthologs

Genomic context

See PHF20 in Genome Data Viewer
Location:
20q11.22-q11.23
Exon count:
23
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (35772003..35950372)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34359923..34538292)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 39 Neighboring gene ribosome production factor 2 homolog pseudogene 1 Neighboring gene cytochrome c oxidase subunit 7B pseudogene 2 Neighboring gene PHF20 intron CAGE-defined high expression enhancer Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 16 Neighboring gene RNA, U4 small nuclear 40, pseudogene Neighboring gene RNA, U6 small nuclear 937, pseudogene Neighboring gene SCAN domain containing 1 Neighboring gene cyclic nucleotide binding domain containing 2 Neighboring gene non-coding RNA activated by DNA damage

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystemAssociation of TP53 (p53) with various transcriptional co-factors can promote, inhibit or provide specificity towards either transcription of cell cycle arrest genes or transcription of cell death ge...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ33479

Gene Ontology Provided by GOA

Process Evidence Code Pubs
histone H4-K16 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K5 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K8 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
PHD finger protein 20
Names
glioma-expressed antigen 2
hepatocellular carcinoma-associated antigen 58
novel zinc finger protein
transcription factor TZP
tudor domain containing 20A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016436.5NP_057520.2  PHD finger protein 20

    See identical proteins and their annotated locations for NP_057520.2

    Status: VALIDATED

    Source sequence(s)
    AL109965, AL137330, AY027523, BC093405
    Consensus CDS
    CCDS13268.1
    UniProtKB/Swiss-Prot
    Q9BVI0
    Related
    ENSP00000363124.3, ENST00000374012.8
    Conserved Domains (4) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15634
    Location:654697
    PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)
    pfam12618
    Location:176259
    DUF3776; Protein of unknown function (DUF3776)
    cl17705
    Location:368
    MBT; mbt repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    35772003..35950372
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027869.2XP_016883358.1  PHD finger protein 20 isoform X2

    Conserved Domains (2) summary
    cd15634
    Location:538581
    PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)
    pfam10243
    Location:28197
    MIP-T3; Microtubule-binding protein MIP-T3
  2. XM_011528843.2XP_011527145.1  PHD finger protein 20 isoform X3

    See identical proteins and their annotated locations for XP_011527145.1

    Conserved Domains (1) summary
    cl22851
    Location:251294
    PHD_SF; PHD finger superfamily
  3. XM_024451890.1XP_024307658.1  PHD finger protein 20 isoform X4

    Conserved Domains (1) summary
    cl22851
    Location:182225
    PHD_SF; PHD finger superfamily
  4. XM_017027871.2XP_016883360.1  PHD finger protein 20 isoform X3

    Conserved Domains (1) summary
    cl22851
    Location:251294
    PHD_SF; PHD finger superfamily
  5. XM_017027868.2XP_016883357.1  PHD finger protein 20 isoform X1

  6. XM_017027870.2XP_016883359.1  PHD finger protein 20 isoform X2

    Conserved Domains (2) summary
    cd15634
    Location:538581
    PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)
    pfam10243
    Location:28197
    MIP-T3; Microtubule-binding protein MIP-T3
  7. XM_024451889.1XP_024307657.1  PHD finger protein 20 isoform X2

    Conserved Domains (2) summary
    cd15634
    Location:538581
    PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)
    pfam10243
    Location:28197
    MIP-T3; Microtubule-binding protein MIP-T3
  8. XM_005260421.3XP_005260478.1  PHD finger protein 20 isoform X3

    See identical proteins and their annotated locations for XP_005260478.1

    Conserved Domains (1) summary
    cl22851
    Location:251294
    PHD_SF; PHD finger superfamily
  9. XM_011528844.2XP_011527146.1  PHD finger protein 20 isoform X3

    See identical proteins and their annotated locations for XP_011527146.1

    Conserved Domains (1) summary
    cl22851
    Location:251294
    PHD_SF; PHD finger superfamily
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