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PHF20 PHD finger protein 20 [ Homo sapiens (human) ]

Gene ID: 51230, updated on 25-Jan-2024

Summary

Official Symbol
PHF20provided by HGNC
Official Full Name
PHD finger protein 20provided by HGNC
Primary source
HGNC:HGNC:16098
See related
Ensembl:ENSG00000025293 MIM:610335; AllianceGenome:HGNC:16098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NZF; TZP; GLEA2; HCA58; TDRD20A; C20orf104
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Located in cytosol; nuclear membrane; and nucleoplasm. Part of MLL1 complex and histone acetyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.8), brain (RPKM 8.0) and 25 other tissues See more
Orthologs
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Genomic context

See PHF20 in Genome Data Viewer
Location:
20q11.22-q11.23
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (35772015..35950370)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (37493003..37671367)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (34359937..34538292)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak4202 silencer Neighboring gene uncharacterized LOC124904972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12864 Neighboring gene Sharpr-MPRA regulatory region 2555 Neighboring gene ribosome production factor 2 homolog pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17798 Neighboring gene MPRA-validated peak4203 silencer Neighboring gene COX7B pseudogene 2 Neighboring gene PHF20 intron CAGE-defined high expression enhancer Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 16 Neighboring gene RNA, U4 small nuclear 40, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:34494545-34495045 Neighboring gene RNA, U6 small nuclear 937, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17802 Neighboring gene uncharacterized LOC124904982 Neighboring gene SCAN domain containing 1 Neighboring gene cyclic nucleotide binding domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ33479

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of MLL1 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MLL1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of NSL complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
PHD finger protein 20
Names
glioma-expressed antigen 2
hepatocellular carcinoma-associated antigen 58
novel zinc finger protein
transcription factor TZP
tudor domain containing 20A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016436.5NP_057520.2  PHD finger protein 20

    See identical proteins and their annotated locations for NP_057520.2

    Status: VALIDATED

    Source sequence(s)
    AL109965, AL137330, AY027523, BC093405
    Consensus CDS
    CCDS13268.1
    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22
    Related
    ENSP00000363124.3, ENST00000374012.8
    Conserved Domains (4) summary
    cd04508
    Location:90135
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    cd15634
    Location:654697
    PHD_PHF20; PHD finger found in PHD finger protein 20 (PHF20)
    pfam12618
    Location:176259
    DUF3776; Protein of unknown function (DUF3776)
    cl17705
    Location:368
    MBT; mbt repeat

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    35772015..35950370
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440180.1XP_047296136.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22
  2. XM_017027868.3XP_016883357.1  PHD finger protein 20 isoform X2

  3. XM_047440181.1XP_047296137.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22
  4. XM_047440182.1XP_047296138.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22
  5. XM_047440184.1XP_047296140.1  PHD finger protein 20 isoform X4

  6. XM_047440183.1XP_047296139.1  PHD finger protein 20 isoform X3

  7. XM_005260421.4XP_005260478.1  PHD finger protein 20 isoform X4

    See identical proteins and their annotated locations for XP_005260478.1

    Conserved Domains (1) summary
    cl22851
    Location:251294
    PHD_SF; PHD finger superfamily
  8. XM_047440186.1XP_047296142.1  PHD finger protein 20 isoform X4

  9. XM_047440185.1XP_047296141.1  PHD finger protein 20 isoform X4

  10. XM_011528844.3XP_011527146.1  PHD finger protein 20 isoform X4

    See identical proteins and their annotated locations for XP_011527146.1

    Conserved Domains (1) summary
    cl22851
    Location:251294
    PHD_SF; PHD finger superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    37493003..37671367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323469.1XP_054179444.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22
  2. XM_054323472.1XP_054179447.1  PHD finger protein 20 isoform X2

  3. XM_054323470.1XP_054179445.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22
  4. XM_054323471.1XP_054179446.1  PHD finger protein 20 isoform X1

    UniProtKB/Swiss-Prot
    A7E235, B2RB56, E1P5S3, Q566Q2, Q5JWY9, Q66K49, Q9BVI0, Q9BWV4, Q9BXA3, Q9BZW3, Q9H421, Q9H4J6, Q9NZ22
  5. XM_054323474.1XP_054179449.1  PHD finger protein 20 isoform X4

  6. XM_054323473.1XP_054179448.1  PHD finger protein 20 isoform X3

  7. XM_054323475.1XP_054179450.1  PHD finger protein 20 isoform X4

  8. XM_054323478.1XP_054179453.1  PHD finger protein 20 isoform X4

  9. XM_054323477.1XP_054179452.1  PHD finger protein 20 isoform X4

  10. XM_054323476.1XP_054179451.1  PHD finger protein 20 isoform X4