PLCE1 phospholipase C epsilon 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLCE1provided by HGNC
Official Full Name: phospholipase C epsilon 1provided by HGNC
Primary source: HGNC:HGNC:17175
See related: Ensembl:ENSG00000138193 MIM:608414; AllianceGenome:HGNC:17175
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PLCE; PPLC; NPHS3
Summary: This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
Expression: Broad expression in colon (RPKM 6.3), endometrium (RPKM 5.5) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10q23.33

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (93993931..94332823)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (94872907..95211918)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (95753688..96092580)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PLCepsilon promotes the Warburg effect and tumorigenesis through AKT/GSK3beta/Cdc25a in bladder cancer.
Title: PLCε promotes the Warburg effect and tumorigenesis through AKT/GSK3β/Cdc25a in bladder cancer.
Phospholipase C epsilon-1 (PLCE1) mediates macrophage activation and protection against tuberculosis.
Title: Phospholipase C epsilon-1 (PLCƐ1) mediates macrophage activation and protection against tuberculosis.
Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families.
Title: Copy number variation analysis in 138 families with steroid-resistant nephrotic syndrome identifies causal homozygous deletions in PLCE1 and NPHS2 in two families.
Association between the Missense Variant of PLCE1 and the Risk of Colorectal Cancer.
Title: Association between the Missense Variant of PLCE1 and the Risk of Colorectal Cancer.
Phospholipase Cepsilon insufficiency causes ascending aortic aneurysm and dissection.
Title: Phospholipase Cε insufficiency causes ascending aortic aneurysm and dissection.
[Association of GSTP1 and PLCE1 gene polymorphisms with primary esophageal cancer].
Title: [Association of GSTP1 and PLCE1 gene polymorphisms with primary esophageal cancer].
PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway.
Title: PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway.
PLCE1 as a diagnostic and prognostic biomarker by promoting the growth and progression of oral squamous cell carcinoma.
Title: PLCE1 as a diagnostic and prognostic biomarker by promoting the growth and progression of oral squamous cell carcinoma.
A broad clinical spectrum of PLCepsilon1-related kidney disease and intrafamilial variability.
Title: A broad clinical spectrum of PLCε1-related kidney disease and intrafamilial variability.
The Frequency of Genetic Mutations in Pediatric Patients Diagnosed with Nephrotic Syndrome: A Single-Center Retrospective Study in Saudi Arabia.
Title: The Frequency of Genetic Mutations in Pediatric Patients Diagnosed with Nephrotic Syndrome: A Single-Center Retrospective Study in Saudi Arabia.

Submit: New GeneRIF Correction See all GeneRIFs (142)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Nephrotic syndrome, type 3 MedGen: C1853124 OMIM: 610725 GeneReviews: Genetic Steroid-Resistant Nephrotic Syndrome Overview	Compare labs

EBI GWAS Catalog

Description
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of personality traits in bipolar patients. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of smoking behaviours in patients with COPD. EBI GWAS Catalog EBI GWAS CatalogPubMed
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells	PubMed
Tat	tat	Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat	PubMed
	tat	HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

CHLC.GGAA2E03 (e-PCR)
- UniSTS:3604

SHGC-155395 (e-PCR)
- UniSTS:182298

D10S1690 (e-PCR), detects polymorphism
- UniSTS:28700

SHGC-146273 (e-PCR)
- UniSTS:172577

D10S1866 (e-PCR)
- UniSTS:24873

D8S2279 (e-PCR)
- UniSTS:473907

RH15689 (e-PCR)
- UniSTS:34650

STS-N32898 (e-PCR)
- UniSTS:68188

SGC32356 (e-PCR)
- UniSTS:76646

D10S2486 (e-PCR)
- UniSTS:3944

D15S1477 (e-PCR)
- UniSTS:474482

G35317 (e-PCR)
- UniSTS:77944

SHGC-106417 (e-PCR)
- UniSTS:169867

D10S1206 (e-PCR)
- UniSTS:82063

D11S3114 (e-PCR)
- UniSTS:152207

SHGC-80953 (e-PCR)
- UniSTS:102586

A006P39 (e-PCR)
- UniSTS:57283

RH68622 (e-PCR)
- UniSTS:49361

G20699 (e-PCR)
- UniSTS:70099

A006C18 (e-PCR)
- UniSTS:70100

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables guanyl-nucleotide exchange factor activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol phospholipase C activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in diacylglycerol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diacylglycerol biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in glomerulus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Names: PLC-epsilon-1; pancreas-enriched phospholipase C; phosphoinositide phospholipase C; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1

NP_001159451.1

EC 3.1.4.11

NP_001275918.1

EC 3.1.4.11

NP_057425.3

EC 3.1.4.11

XP_006717948.1

EC 3.1.4.11

XP_006717951.1

EC 3.1.4.11

XP_006717953.1

EC 3.1.4.11

XP_011538152.1

EC 3.1.4.11

XP_011538153.1

EC 3.1.4.11

XP_011538154.1

EC 3.1.4.11

XP_016871799.1

EC 3.1.4.11

XP_016871800.1

EC 3.1.4.11

XP_016871801.1

EC 3.1.4.11

XP_047281240.1

EC 3.1.4.11

XP_047281241.1

EC 3.1.4.11

XP_047281242.1

EC 3.1.4.11

XP_047281243.1

EC 3.1.4.11

XP_047281244.1

EC 3.1.4.11

XP_047281245.1

EC 3.1.4.11

XP_047281246.1

EC 3.1.4.11

XP_047281247.1

EC 3.1.4.11

XP_047281248.1

EC 3.1.4.11

XP_047281249.1

EC 3.1.4.11

XP_047281250.1

EC 3.1.4.11

XP_047281251.1

EC 3.1.4.11

XP_047281252.1

EC 3.1.4.11

XP_047281253.1

EC 3.1.4.11

XP_047281254.1

EC 3.1.4.11

XP_047281255.1

EC 3.1.4.11

XP_047281256.1

EC 3.1.4.11

XP_047281257.1

EC 3.1.4.11

XP_047281258.1

EC 3.1.4.11

XP_047281259.1

EC 3.1.4.11

XP_054221979.1

EC 3.1.4.11

XP_054221980.1

EC 3.1.4.11

XP_054221981.1

EC 3.1.4.11

XP_054221982.1

EC 3.1.4.11

XP_054221983.1

EC 3.1.4.11

XP_054221984.1

EC 3.1.4.11

XP_054221985.1

EC 3.1.4.11

XP_054221986.1

EC 3.1.4.11

XP_054221987.1

EC 3.1.4.11

XP_054221988.1

EC 3.1.4.11

XP_054221989.1

EC 3.1.4.11

XP_054221990.1

EC 3.1.4.11

XP_054221991.1

EC 3.1.4.11

XP_054221992.1

EC 3.1.4.11

XP_054221993.1

EC 3.1.4.11

XP_054221994.1

EC 3.1.4.11

XP_054221995.1

EC 3.1.4.11

XP_054221996.1

EC 3.1.4.11

XP_054221997.1

EC 3.1.4.11

XP_054221998.1

EC 3.1.4.11

XP_054221999.1

EC 3.1.4.11

XP_054222000.1

EC 3.1.4.11

XP_054222001.1

EC 3.1.4.11

XP_054222002.1

EC 3.1.4.11

XP_054222003.1

EC 3.1.4.11

XP_054222004.1

EC 3.1.4.11

XP_054222005.1

EC 3.1.4.11

XP_054222006.1

EC 3.1.4.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_015799.2 RefSeqGene

Range

5002..343894

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001165979.2 → NP_001159451.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 2

See identical proteins and their annotated locations for NP_001159451.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two exons and has an additional novel exon at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a novel start codon, compared to variant 1. The encoded protein (isoform 2; also known as PLCepsilon1b) has a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AF170071, AK289852, BC151854, BX491865

Consensus CDS

CCDS53555.1

UniProtKB/TrEMBL

A0A7I2PPM5

Related

ENSP00000501910.1, ENST00000675218.1

Conserved Domains (6) summary

cd00275
Location:1564 → 1676

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd01780
Location:1829 → 1928

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1083 → 1525

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:1010 → 1675

PLN02952; phosphoinositide phospholipase C

pfam00617
Location:231 → 405

RasGEF; RasGEF domain

pfam09279
Location:1020 → 1071

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
NM_001288989.2 → NP_001275918.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 3

See identical proteins and their annotated locations for NP_001275918.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AL139124, AL355341, AL365510, BC144286, BC151854

Consensus CDS

CCDS91304.1

UniProtKB/TrEMBL

A0A8I5KVG7, B7ZM61

Related

ENSP00000508605.1, ENST00000692396.1

Conserved Domains (6) summary

cd00275
Location:1856 → 1968

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1375 → 1817

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:1302 → 1967

PLN02952; phosphoinositide phospholipase C

pfam00617
Location:539 → 713

RasGEF; RasGEF domain

pfam09279
Location:1312 → 1363

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl00155
Location:2121 → 2220

UBQ; Ubiquitin-like proteins
NM_016341.4 → NP_057425.3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1

See identical proteins and their annotated locations for NP_057425.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1; also known as PLCepsilon1a).

Source sequence(s)

AB040949, AF117948, AK074239, AL139124, AL355341, AL365510

Consensus CDS

CCDS41552.1

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

UniProtKB/TrEMBL

A0A8I5KVG7

Related

ENSP00000360431.2, ENST00000371380.8

Conserved Domains (6) summary

cd08596
Location:1391 → 1833

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:1318 → 1983

PLN02952; phosphoinositide phospholipase C

cd16203
Location:1198 → 1378

EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)

cd01780
Location:2134 → 2236

RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

cd17229
Location:2007 → 2114

RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon

pfam00617
Location:539 → 713

RasGEF; RasGEF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000010.11 Reference GRCh38.p14 Primary Assembly

Range

93993931..94332823

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047425285.1 → XP_047281241.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_047425289.1 → XP_047281245.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_047425297.1 → XP_047281253.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

B7ZM61
XM_047425287.1 → XP_047281243.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_017016310.3 → XP_016871799.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

UniProtKB/TrEMBL

A0A8I5KVG7

Conserved Domains (6) summary

cd00275
Location:1886 → 1998

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1391 → 1847

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:1318 → 1997

PLN02952; phosphoinositide phospholipase C

pfam00617
Location:539 → 713

RasGEF; RasGEF domain

pfam09279
Location:1328 → 1379

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl00155
Location:2151 → 2250

UBQ; Ubiquitin-like proteins
XM_047425290.1 → XP_047281246.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_047425286.1 → XP_047281242.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_006717885.5 → XP_006717948.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

See identical proteins and their annotated locations for XP_006717948.1

UniProtKB/TrEMBL

A0A8I5KVG7

Conserved Domains (6) summary

cd00275
Location:1886 → 1998

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1391 → 1847

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:1318 → 1997

PLN02952; phosphoinositide phospholipase C

pfam00617
Location:539 → 713

RasGEF; RasGEF domain

pfam09279
Location:1328 → 1379

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl00155
Location:2151 → 2250

UBQ; Ubiquitin-like proteins
XM_006717888.5 → XP_006717951.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

UniProtKB/TrEMBL

A0A8I5KVG7

Conserved Domains (6) summary

cd00275
Location:1885 → 1997

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1391 → 1846

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:1318 → 1996

PLN02952; phosphoinositide phospholipase C

pfam00617
Location:539 → 713

RasGEF; RasGEF domain

pfam09279
Location:1328 → 1379

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl00155
Location:2150 → 2249

UBQ; Ubiquitin-like proteins
XM_047425284.1 → XP_047281240.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_047425291.1 → XP_047281247.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_047425296.1 → XP_047281252.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4
XM_047425298.1 → XP_047281254.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

B7ZM61
XM_047425294.1 → XP_047281250.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_017016311.3 → XP_016871800.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

UniProtKB/TrEMBL

A0A8I5KVG7

Conserved Domains (6) summary

cd00275
Location:1886 → 1998

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd08596
Location:1391 → 1847

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:1318 → 1997

PLN02952; phosphoinositide phospholipase C

pfam00617
Location:539 → 713

RasGEF; RasGEF domain

pfam09279
Location:1328 → 1379

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl00155
Location:2151 → 2250

UBQ; Ubiquitin-like proteins
XM_047425288.1 → XP_047281244.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2
XM_047425292.1 → XP_047281248.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_047425293.1 → XP_047281249.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3

Related

ENSP00000509490.1, ENST00000692286.1
XM_011539851.4 → XP_011538153.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X12

UniProtKB/TrEMBL

A0A8I5KV08

Conserved Domains (3) summary

pfam00617
Location:539 → 713

RasGEF; RasGEF domain

pfam09279
Location:1328 → 1379

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl14615
Location:1391 → 1530

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
XM_011539852.4 → XP_011538154.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X13

UniProtKB/TrEMBL

A0A8I5KV08

Related

ENSP00000508416.1, ENST00000686954.1

Conserved Domains (3) summary

pfam00617
Location:539 → 713

RasGEF; RasGEF domain

pfam09279
Location:1328 → 1379

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl14615
Location:1391 → 1530

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
XM_047425295.1 → XP_047281251.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4
XM_047425300.1 → XP_047281256.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

B7ZM61
XM_047425299.1 → XP_047281255.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

B7ZM61
XM_006717890.4 → XP_006717953.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

UniProtKB/TrEMBL

A0A7I2PPM5

Conserved Domains (6) summary

cd00275
Location:1578 → 1690

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd01780
Location:1843 → 1942

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1083 → 1539

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:1010 → 1689

PLN02952; phosphoinositide phospholipase C

pfam00617
Location:231 → 405

RasGEF; RasGEF domain

pfam09279
Location:1020 → 1071

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
XM_047425302.1 → XP_047281258.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8
XM_017016312.3 → XP_016871801.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

UniProtKB/TrEMBL

A0A7I2PPM5, A0A8I5KXT2

Related

ENSP00000509140.1, ENST00000688810.1
XM_047425301.1 → XP_047281257.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7

Related

ENSP00000360426.1, ENST00000371375.2
XM_011539850.4 → XP_011538152.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10

UniProtKB/TrEMBL

A0A7I2PPM5

Conserved Domains (6) summary

cd00275
Location:1501 → 1613

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd01780
Location:1766 → 1865

PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase

cd08596
Location:1006 → 1462

PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon

PLN02952
Location:933 → 1612

PLN02952; phosphoinositide phospholipase C

pfam00617
Location:154 → 328

RasGEF; RasGEF domain

pfam09279
Location:943 → 994

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
XM_047425303.1 → XP_047281259.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X11

Alternate T2T-CHM13v2.0

Genomic

NC_060934.1 Alternate T2T-CHM13v2.0

Range

94872907..95211918

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054366006.1 → XP_054221981.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_054366015.1 → XP_054221990.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_054366023.1 → XP_054221998.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

B7ZM61
XM_054366016.1 → XP_054221991.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_054366012.1 → XP_054221987.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_054366019.1 → XP_054221994.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4
XM_054366020.1 → XP_054221995.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

B7ZM61
XM_054366008.1 → XP_054221983.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_054366009.1 → XP_054221984.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_054366013.1 → XP_054221988.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_054366007.1 → XP_054221982.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_054366005.1 → XP_054221980.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_054366010.1 → XP_054221985.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2
XM_054366017.1 → XP_054221992.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_054366004.1 → XP_054221979.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
XM_054366011.1 → XP_054221986.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2
XM_054366014.1 → XP_054221989.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

UniProtKB/Swiss-Prot

A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
XM_054366030.1 → XP_054222005.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X12
XM_054366031.1 → XP_054222006.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X13
XM_054366018.1 → XP_054221993.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4
XM_054366022.1 → XP_054221997.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

B7ZM61
XM_054366021.1 → XP_054221996.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

UniProtKB/TrEMBL

B7ZM61
XM_054366028.1 → XP_054222003.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10
XM_054366029.1 → XP_054222004.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X11
XM_054366024.1 → XP_054221999.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6
XM_054366026.1 → XP_054222001.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8
XM_054366027.1 → XP_054222002.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

UniProtKB/TrEMBL

A0A8I5KXT2
XM_054366025.1 → XP_054222000.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7