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ZNF639 zinc finger protein 639 [ Homo sapiens (human) ]

Gene ID: 51193, updated on 12-Oct-2019

Summary

Official Symbol
ZNF639provided by HGNC
Official Full Name
zinc finger protein 639provided by HGNC
Primary source
HGNC:HGNC:30950
See related
Ensembl:ENSG00000121864
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZASC1; ANC-2H01; ANC_2H01
Summary
This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in thyroid (RPKM 9.3), bone marrow (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF639 in Genome Data Viewer
Location:
3q26.33
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (179322910..179338583)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (179041551..179053325)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Neighboring gene potassium calcium-activated channel subfamily M regulatory beta subunit 3 Neighboring gene LRR binding FLII interacting protein 1 pseudogene 1 Neighboring gene mitofusin 1 Neighboring gene G protein subunit beta 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat ZASC1 interacts with HIV-1 Tat and cellular proteins CDK9/Cyclin T1 (P-TEFb) in a TAR-independent manner, suggesting that the Tat/P-TEFb complex in the transcriptional elongation site is promoted by ZASC1 PubMed
tat ZASC1, a cellular transcription factor, stimulates HIV-1 Tat-mediated transcription elongation from the HIV-1 promoter in primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16532, 6230400O18Rik

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 639
Names
zinc finger amplified in esophageal squamous cell carcinomas 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303425.2NP_001290354.1  zinc finger protein 639

    See identical proteins and their annotated locations for NP_001290354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB097862, AC007823, BC026181, BF799661, BP260931, DB457196
    Consensus CDS
    CCDS3227.1
    UniProtKB/Swiss-Prot
    Q9UID6
    Conserved Domains (2) summary
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408481
    zf-C2H2_8; C2H2-type zinc ribbon
  2. NM_001303426.2NP_001290355.1  zinc finger protein 639

    See identical proteins and their annotated locations for NP_001290355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB097862, AC007823, BC026181, BP260931, DB457196
    Consensus CDS
    CCDS3227.1
    UniProtKB/Swiss-Prot
    Q9UID6
    Related
    ENSP00000417740.1, ENST00000496856.6
    Conserved Domains (2) summary
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408481
    zf-C2H2_8; C2H2-type zinc ribbon
  3. NM_016331.2NP_057415.1  zinc finger protein 639

    See identical proteins and their annotated locations for NP_057415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB097862, AC007823, BC020500, BP260931
    Consensus CDS
    CCDS3227.1
    UniProtKB/Swiss-Prot
    Q9UID6
    Related
    ENSP00000325634.3, ENST00000326361.7
    Conserved Domains (2) summary
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408481
    zf-C2H2_8; C2H2-type zinc ribbon

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    179322910..179338583
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006551.1XP_016862040.1  zinc finger protein 639 isoform X1

    UniProtKB/Swiss-Prot
    Q9UID6
    Conserved Domains (2) summary
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408481
    zf-C2H2_8; C2H2-type zinc ribbon
  2. XM_017006552.1XP_016862041.1  zinc finger protein 639 isoform X1

    UniProtKB/Swiss-Prot
    Q9UID6
    Related
    ENSP00000418766.1, ENST00000484866.5
    Conserved Domains (2) summary
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408481
    zf-C2H2_8; C2H2-type zinc ribbon
  3. XM_017006553.1XP_016862042.1  zinc finger protein 639 isoform X1

    UniProtKB/Swiss-Prot
    Q9UID6
    Conserved Domains (2) summary
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408481
    zf-C2H2_8; C2H2-type zinc ribbon
  4. XM_017006550.1XP_016862039.1  zinc finger protein 639 isoform X1

    UniProtKB/Swiss-Prot
    Q9UID6
    Conserved Domains (2) summary
    sd00017
    Location:405425
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam15909
    Location:408481
    zf-C2H2_8; C2H2-type zinc ribbon
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